Zobrazeno 1 - 10
of 397
pro vyhledávání: '"THOMAS MAVROMOUSTAKOS"'
Autor:
Nikitas Georgiou, Eleni Chontzopoulou, Efthymios Alexandros Routsi, Irene Georgia Stavrakaki, Errikos Petsas, Nikoletta Zoupanou, Margarita Georgia Kakava, Demeter Tzeli, Thomas Mavromoustakos, Sofia Kiriakidi
Publikováno v:
ACS Omega, Vol 9, Iss 45, Pp 44876-44890 (2024)
Externí odkaz:
https://doaj.org/article/7106b46e380b4b2793f636e21d6821df
Docking, MD Simulations, and DFT Calculations: Assessing W254’s Function and Sartan Binding in Furin
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 8, Pp 8226-8238 (2024)
Furins are serine endoproteases that are involved in many biological processes, where they play important roles in normal metabolism, in the activation of various pathogens, while they are a target for therapeutic intervention. Dichlorophenyl-pyridin
Externí odkaz:
https://doaj.org/article/1ca5eb799e2d4b739691d5b9e5790449
Autor:
Panagiotis Ntavaroukas, Konstantinos Michail, Rafaela Tsiakalidou, Eleni Stampouloglou, Katerina Tsiggene, Dimitrios Komiotis, Nikitas Georgiou, Thomas Mavromoustakos, Stella Manta, Danielle Aje, Panagiotis Michael, Barry J. Campbell, Stamatia Papoutsopoulou
Publikováno v:
Biology, Vol 13, Iss 11, p 910 (2024)
The NF-κB family of transcription factors is a master regulator of cellular responses during inflammation, and its dysregulation has been linked to chronic inflammatory diseases, such as inflammatory bowel disease. It is therefore of vital importanc
Externí odkaz:
https://doaj.org/article/0793f7f718f342bf93b61940f422f788
Autor:
Nikitas Georgiou, Danai Karta, Antigoni Cheilari, Franci Merzel, Demeter Tzeli, Stamatia Vassiliou, Thomas Mavromoustakos
Publikováno v:
Molecules, Vol 29, Iss 11, p 2458 (2024)
Thiazolin-4-ones and their derivatives represent important heterocyclic scaffolds with various applications in medicinal chemistry. For that reason, the synthesis of two 5-substituted thiazolidin-4-one derivatives was performed. Their structure assig
Externí odkaz:
https://doaj.org/article/4763802aa54a4fc4921fb2dc5177c057
Autor:
Panagiou Mavroeidi, Leandros P. Zorba, Nikolaos V. Tzouras, Stavros P. Neofotistos, Nikitas Georgiou, Kader Sahin, Murat Şentürk, Serdar Durdagi, Georgios C. Vougioukalakis, Thomas Mavromoustakos
Publikováno v:
Molecules, Vol 29, Iss 11, p 2486 (2024)
A versatile family of quaternary propargylamines was synthesized employing the KA2 multicomponent reaction, through the single-step coupling of a number of amines, ketones, and terminal alkynes. Sustainable synthetic procedures using transition metal
Externí odkaz:
https://doaj.org/article/84f8841a1168464e927770c6a6976733
Autor:
Nikitas Georgiou, Margarita Georgia Kakava, Efthymios Alexandros Routsi, Errikos Petsas, Nikolaos Stavridis, Christoforos Freris, Nikoletta Zoupanou, Kalliopi Moschovou, Sofia Kiriakidi, Thomas Mavromoustakos
Publikováno v:
Molecules, Vol 28, Iss 24, p 8141 (2023)
The study of natural products as potential drug leads has gained tremendous research interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and, more specifically, flavonols. This review summarizes the beneficial
Externí odkaz:
https://doaj.org/article/ee765bba3ab64084bd0e0587500f4586
Autor:
Harry Ridgway, Graham J. Moore, Thomas Mavromoustakos, Sotirios Tsiodras, Irene Ligielli, Konstantinos Kelaidonis, Christos T. Chasapis, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Russell Petty, Ioannis Karakasiliotis, Vassilis G. Gorgoulis, John M. Matsoukas
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2091-2111 (2022)
The discovery and facile synthesis of a new class of sartan-like arterial antihypertensive drugs (angiotensin receptor blockers [ARBs]), subsequently referred to as “bisartans” is reported. In vivo results and complementary molecular modelling pr
Externí odkaz:
https://doaj.org/article/c273711c046740748e8c42638b922ec3
Publikováno v:
Macromol, Vol 1, Iss 3, Pp 177-200 (2021)
The current study is focused on the development of highly stable drug nanocarriers by encapsulating losartan potassium (LSR) into an amphiphilic biocompatible poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) (PMeOxz72-grad-PPhOxz28) gradien
Externí odkaz:
https://doaj.org/article/dd0ef854c3af43819bb197150d25b713
Autor:
Despoina P. Kiouri, Charalampos Ntallis, Konstantinos Kelaidonis, Massimiliano Peana, Sotirios Tsiodras, Thomas Mavromoustakos, Alessandro Giuliani, Harry Ridgway, Graham J. Moore, John M. Matsoukas, Christos T. Chasapis
Publikováno v:
Proteomes, Vol 11, Iss 2, p 21 (2023)
The potential of targeting the Renin-Angiotensin-Aldosterone System (RAAS) as a treatment for the coronavirus disease 2019 (COVID-19) is currently under investigation. One way to combat this disease involves the repurposing of angiotensin receptor bl
Externí odkaz:
https://doaj.org/article/b9dba9a5c93f4d56b563f3e09625703a
Autor:
Sofia Kiriakidi, Christos Chatzigiannis, Christina Papaemmanouil, Andreas G. Tzakos, Zoe Cournia, Thomas Mavromoustakos
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 110-120 (2021)
Hypertension, mediated by the Angiotensin II receptor type 1 (AT1R), is still the major cause of premature death despite the discovery of novel therapeutics, highlighting the importance of an in depth understanding of the drug-AT1R recognition mechan
Externí odkaz:
https://doaj.org/article/6b8fbd409b8248baade002996b21362d