Zobrazeno 1 - 10
of 571
pro vyhledávání: '"THOMAS F. MEYER"'
Inhibition of ADAM17 increases the cytotoxic effect of cisplatin in cervical spheroids and organoids
Autor:
David Holthaus, Christoph Rogmans, Ina Gursinski, Alvaro Quevedo-Olmos, Marzieh Ehsani, Mandy Mangler, Inken Flörkemeier, Jörg P. Weimer, Thomas F. Meyer, Nicolai Maass, Dirk O. Bauerschlag, Nina Hedemann
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionCervical cancer represents one of the main causes of female, cancer-related mortality worldwide. The majority of cancers are caused by human papillomaviruses such as HPV16 and HPV18. As chemotherapeutic resistance to first-line platinum t
Externí odkaz:
https://doaj.org/article/03b213b6b8984864bcfc1799a85cfa7e
Autor:
Naveen Kumar, Pon Ganish Prakash, Christian Wentland, Shilpa Mary Kurian, Gaurav Jethva, Volker Brinkmann, Hans-Joachim Mollenkopf, Tobias Krammer, Christophe Toussaint, Antoine-Emmanuel Saliba, Matthias Biebl, Christian Jürgensen, Bertram Wiedenmann, Thomas F. Meyer, Rajendra Kumar Gurumurthy, Cindrilla Chumduri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The gastroesophageal squamocolumnar junction (GE-SCJ) is a critical tissue interface between the esophagus and stomach, with significant relevance in the pathophysiology of gastrointestinal diseases. Despite this, the molecular mechanisms un
Externí odkaz:
https://doaj.org/article/92e5c859ad5a452d9912442eb093da20
Autor:
Megi Vllahu, Antonia Voli, Valerio Licursi, Claudia Zagami, Antonella D’Amore, Jan Traulsen, Sara Woelffling, Monika Schmid, Robbie Crickley, Richard Lisle, Alexander Link, Alessandra Tosco, Thomas F. Meyer, Francesco Boccellato
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The mucus serves as a protective barrier in the gastrointestinal tract against microbial attacks. While its role extends beyond merely being a physical barrier, the extent of its active bactericidal properties remains unclear, and the mechanisms regu
Externí odkaz:
https://doaj.org/article/a62ae5e7ae464a93a97be77824751854
Autor:
Junxue Dong, David Holthaus, Christian Peters, Stefanie Koster, Marzieh Ehsani, Alvaro Quevedo-Olmos, Hilmar Berger, Michal Zarobkiewicz, Mandy Mangler, Rajendra Kumar Gurumurthy, Nina Hedemann, Cindrilla Chumduri, Dieter Kabelitz, Thomas F. Meyer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cervical cancer is a leading cause of death among women globally, primarily driven by high-risk papillomaviruses. However, the effectiveness of chemotherapy is limited, underscoring the potential of personalized immunotherapies. Patient-derived organ
Externí odkaz:
https://doaj.org/article/22cb8b5291094598b7ec152c0b00f6f2
Autor:
Rajendra Kumar Gurumurthy, Klaus-Peter Pleissner, Cindrilla Chumduri, Thomas F. Meyer, André P. Mäurer
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background High-content screening (HCS) experiments generate complex data from multiple object features for each cell within a treated population. Usually, these data are analyzed by using population-averaged values of the features of intere
Externí odkaz:
https://doaj.org/article/5b6b0d5b8bbf4dc8ad72085d29d01ec1
Autor:
Marta Kapalczynska, Manqiang Lin, Jeroen Maertzdorf, Julian Heuberger, Stefanie Muellerke, Xiangsheng Zuo, Ramon Vidal, Imad Shureiqi, Anne-Sophie Fischer, Sascha Sauer, Hilmar Berger, Evelyn Kidess, Hans-Joachim Mollenkopf, Frank Tacke, Thomas F. Meyer, Michael Sigal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Helicobacter pylori causes gastric inflammation, gland hyperplasia and is linked to gastric cancer. Here the authors identify a BMP feedback loop between the stomach epithelium and surrounding stroma that controls gland homeostasis and demonstrate it
Externí odkaz:
https://doaj.org/article/d77fc1814d4b4a59a4f1c341261c1b01
Autor:
Stefanie Koster, Rajendra Kumar Gurumurthy, Naveen Kumar, Pon Ganish Prakash, Jayabhuvaneshwari Dhanraj, Sofia Bayer, Hilmar Berger, Shilpa Mary Kurian, Marina Drabkina, Hans-Joachim Mollenkopf, Christian Goosmann, Volker Brinkmann, Zachary Nagel, Mandy Mangler, Thomas F. Meyer, Cindrilla Chumduri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Koster et al., model human papillomavirus and Chlamydia coinfection dynamics in patient-derived ectocervical organoids, and characterize the effects of multiple infections in the cellular microenvironment, potentially contributing to neoplasia.
Externí odkaz:
https://doaj.org/article/2fb21c954d7549fe9ee43a376dd4e07a
Autor:
Nils C. Gassen, Jan Papies, Thomas Bajaj, Jackson Emanuel, Frederik Dethloff, Robert Lorenz Chua, Jakob Trimpert, Nicolas Heinemann, Christine Niemeyer, Friderike Weege, Katja Hönzke, Tom Aschman, Daniel E. Heinz, Katja Weckmann, Tim Ebert, Andreas Zellner, Martina Lennarz, Emanuel Wyler, Simon Schroeder, Anja Richter, Daniela Niemeyer, Karen Hoffmann, Thomas F. Meyer, Frank L. Heppner, Victor M. Corman, Markus Landthaler, Andreas C. Hocke, Markus Morkel, Nikolaus Osterrieder, Christian Conrad, Roland Eils, Helena Radbruch, Patrick Giavalisco, Christian Drosten, Marcel A. Müller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Externí odkaz:
https://doaj.org/article/a210cbf8766241fd8d824076b3b287b5
Autor:
Amina Iftekhar, Hilmar Berger, Nassim Bouznad, Julian Heuberger, Francesco Boccellato, Ulrich Dobrindt, Heiko Hermeking, Michael Sigal, Thomas F. Meyer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Colibactin-producing pks+ Escherichia coli are frequent constituents of the human intestinal microbiota. Here, the authors show that short exposure of cells to pks+ E. coli induces chromosomal aberrations, genomic instability, and multiple features o
Externí odkaz:
https://doaj.org/article/6216b08bac074ebf879284a8ec39ba76
Autor:
Michael Bauer, Zuzana Nascakova, Anca-Irina Mihai, Phil F. Cheng, Mitchell P. Levesque, Simon Lampart, Robert Hurwitz, Lennart Pfannkuch, Jana Dobrovolna, Melanie Jacobs, Sina Bartfeld, Anders Dohlman, Xiling Shen, Alevtina A. Gall, Nina R. Salama, Antonia Töpfer, Achim Weber, Thomas F. Meyer, Pavel Janscak, Anne Müller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The bacterial pathogen Helicobacter pylori is known for its ability to induce DNA double-strand breaks in the genome of its target cells. Here, we show that H. pylori-induced DNA damage and replication stress occurs in S-phase cells as a result of R-
Externí odkaz:
https://doaj.org/article/776595ded02849959ccfec289f6e8902