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pro vyhledávání: '"THIQ"'
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Autor:
Yixuan Tang, Shihui Huang, Xingxing Chen, Junzhang Huang, Qianwen Lin, Lei Huang, Shuping Wang, Qihua Zhu, Yungen Xu, Yi Zou
Publikováno v:
Molecules, Vol 27, Iss 19, p 6637 (2022)
Protein arginine methyltransferases 5 (PRMT5) is a clinically promising epigenetic target that is upregulated in a variety of tumors. Currently, there are several PRMT5 inhibitors under preclinical or clinical development, however the established cli
Externí odkaz:
https://doaj.org/article/83ebffede0804a04a73ec63580c1e62c
Autor:
Santos, Ana R.N., Sheldrake, Helen M., Ibrahim, Ali I.M., Danta, Chhanda C., Bonanni, D., Daga, M., Oliaro-Bosso, s., Boschi, D., Lolli, M.L., Pors, Klaus
Yes
Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisatio
Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisatio
Externí odkaz:
http://hdl.handle.net/10454/17252
Akademický článek
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Publikováno v:
Natural Product Reports. 39:139-162
Covering: 2015 to 2020Nitrogen heterocyclic natural products (NHNPs) are primary or secondary metabolites containing nitrogen heterocyclic (N-heterocyclic) skeletons. Due to the existence of the N-heterocyclic structure, NHNPs exhibit various bioacti
Publikováno v:
The Journal of Organic Chemistry. 86:15743-15752
A new photocatalyst-free strategy for the cross-dehydrogenative C-C and C-P coupling reaction has been described. This protocol provides a concise method to synthesize various 1-substituted tetrahydroisoquinoline (THIQ) derivatives enabled by visible
Autor:
Andrea Calcaterra, Laura Mangiardi, Giuliano Delle Monache, Deborah Quaglio, Silvia Balducci, Simone Berardozzi, Antonia Iazzetti, Roberta Franzini, Bruno Botta, Francesca Ghirga
Publikováno v:
Molecules, Vol 25, Iss 2, p 414 (2020)
The Pictet-Spengler reaction (P-S) is one of the most direct, efficient, and variable synthetic method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), and polyheterocyclic
Externí odkaz:
https://doaj.org/article/d0c1576082484276834c473bc7c1ddab
Autor:
Max Cárdenas-Fernández, Jutta Siegrist, Fabiana Subrizi, Jennifer N. Andexer, Rebecca Roddan, Yu Wang, Daniel Méndez-Sánchez, Helen C. Hailes, John M. Ward, Benjamin Thair, Michael Richter
Publikováno v:
Angewandte Chemie (International Ed. in English)
The tetrahydroisoquinoline (THIQ) ring system is present in a large variety of structurally diverse natural products exhibiting a wide range of biological activities. Routes to mimic the biosynthetic pathways to such alkaloids, by building cascade re
Autor:
Banoth Karan Kumar, Subhash Chander, Sankaranarayanan Murugesan, Faheem, Selvaraj Kunjiappan, Kondapalli Venkata Gowri Chandra Sekhar
Publikováno v:
Expert Opinion on Drug Discovery. 16:1119-1147
Introduction: Cancer is a dreadful disorder that is emerging as one of the leading causes of mortality across the globe. The complex tumor environment, supplemented with drawbacks of the existing drugs, has made it a global health concern. The Tetrah