Identification of host antioxidant effectors as thioridazine targets: Impact on cardiomyocytes infection and Trypanosoma cruzi-induced acute myocarditis.

Autor: Liz Belli Cassa Domingues E; Programa de Pós-Graduação em Biociências Aplicadas à Saúde, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil., Gonçalves-Santos E; Programa de Pós-Graduação em Biociências Aplicadas à Saúde, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil., Santana Caldas I; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil., Vilela Gonçalves R; Departamento de Biologia Animal, Programa de Pós-Graduação em Biologia Animal, Universidade Federal de Viçosa, Viçosa, 36570-900, Minas Gerais, Brazil; Programa de Pós-Graduação em Biologia Celular e Estrutural, Universidade Federal de Viçosa, Viçosa 36570-900, Minas Gerais, Brazil., Caetano-da-Silva JE; Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil., Cardoso Santos E; Faculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina 39100-000, Minas Gerais, Brazil., Mól Pelinsari S; Programa de Pós-Graduação em Biologia Celular e Estrutural, Universidade Federal de Viçosa, Viçosa 36570-900, Minas Gerais, Brazil., Figueiredo Diniz L; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil., Dias Novaes R; Programa de Pós-Graduação em Biociências Aplicadas à Saúde, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; Departamento de Biologia Animal, Programa de Pós-Graduação em Biologia Animal, Universidade Federal de Viçosa, Viçosa, 36570-900, Minas Gerais, Brazil. Electronic address: romulo.novaes@unifal-mg.edu.br.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Aug; Vol. 1870 (6), pp. 167264. Date of Electronic Publication: 2024 May 26.

Thioridazine reverses trastuzumab resistance in gastric cancer by inhibiting S-phase kinase associated protein 2-mediated aerobic glycolysis.

Autor: Yang ZY; Department of Pathology, School of Basic Medical Sciences, Henan University, Kaifeng 475004, Henan Province, China., Zhao YW; Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng 475004, Henan Province, China., Xue JR; Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng 475004, Henan Province, China., Guo R; Department of Pathology, School of Basic Medical Sciences, Henan University, Kaifeng 475004, Henan Province, China., Zhao Z; Department of Pathology, Henan University-affiliated Zhengzhou Yihe Hospital, Zhengzhou 450000, Henan Province, China., Liu HD; Department of Pathology, School of Basic Medical Sciences, Henan University, Kaifeng 475004, Henan Province, China., Ren ZG; Department of Pathology, School of Basic Medical Sciences, Henan University, Kaifeng 475004, Henan Province, China.; Key Laboratory of Clinical Resources Translation, The First Affiliated Hospital, Henan University, Kaifeng 475004, Henan Province, China. renzhiguang66@outlook.com., Shi M; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China.

Publikováno v: World journal of gastroenterology [World J Gastroenterol] 2023 Dec 07; Vol. 29 (45), pp. 5974-5987.

Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways.

Autor: Tran TH; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112, Taiwan.; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan., Kao M; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan., Liu HS; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.; Center for Cancer Research, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; M. Sc. Program in Tropical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan., Hong YR; Center for Cancer Research, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; Graduate Institutes of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan.; Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan., Su Y; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112, Taiwan. yeusu@nycu.edu.tw.; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. yeusu@nycu.edu.tw., Huang CF; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cyhuang5@nycu.edu.tw.; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. cyhuang5@nycu.edu.tw.

Publikováno v: Cell communication and signaling : CCS [Cell Commun Signal] 2023 Jul 24; Vol. 21 (1), pp. 184. Date of Electronic Publication: 2023 Jul 24.

In vitro antileishmanial activity of thioridazine on amphotericin B unresponsive/ sensitive Leishmania donovani promastigotes and intracellular amastigotes.

Autor: Kumar V; Department of Biochemistry, Rajendra Memorial Research Institute of Medical Sciences, Patna, India., Kumari S; Department of Biochemistry, Rajendra Memorial Research Institute of Medical Sciences, Patna, India., Ranjan R; Department of Biochemistry, Rajendra Memorial Research Institute of Medical Sciences, Patna, India., Kumar A; Department of Biochemistry, Rajendra Memorial Research Institute of Medical Sciences, Patna, India., Alti D; Department of Immunology, Rajendra Memorial Research Institute of Medical Sciences, Patna, India. Electronic address: dayakar.pcu@gmail.com.

Publikováno v: Experimental parasitology [Exp Parasitol] 2024 Feb; Vol. 257, pp. 108688. Date of Electronic Publication: 2023 Dec 22.

The combination of cloxacillin, thioridazine and tetracycline protects mice against Staphylococcus aureus peritonitis by inhibiting α-Hemolysin-induced MAPK/NF-κB/NLRP3 activation.

Autor: Zhou H; State Key Laboratory of Human-Animal Zoonotic infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Department of Infectious Diseases, Department of Endocrinology, Department of Interventional Therapy of First Hospital of Jilin University, Changchun 130062, China., Luan W; State Key Laboratory of Human-Animal Zoonotic infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Department of Infectious Diseases, Department of Endocrinology, Department of Interventional Therapy of First Hospital of Jilin University, Changchun 130062, China., Wang Y; State Key Laboratory of Human-Animal Zoonotic infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Department of Infectious Diseases, Department of Endocrinology, Department of Interventional Therapy of First Hospital of Jilin University, Changchun 130062, China., Song Y; Shenzhen Liyunde Biotechnology Co., Ltd., Shenzhen 518057, China., Xu H; State Key Laboratory of Human-Animal Zoonotic infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Department of Infectious Diseases, Department of Endocrinology, Department of Interventional Therapy of First Hospital of Jilin University, Changchun 130062, China., Tang X; Key Lab for New Drug Research of TCM, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China., Ma Y; State Key Laboratory of Human-Animal Zoonotic infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Department of Infectious Diseases, Department of Endocrinology, Department of Interventional Therapy of First Hospital of Jilin University, Changchun 130062, China., Cui X; State Key Laboratory of Human-Animal Zoonotic infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Department of Infectious Diseases, Department of Endocrinology, Department of Interventional Therapy of First Hospital of Jilin University, Changchun 130062, China., Shi J; State Key Laboratory of Human-Animal Zoonotic infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Department of Infectious Diseases, Department of Endocrinology, Department of Interventional Therapy of First Hospital of Jilin University, Changchun 130062, China., Shen K; Jilin Hepatobiliary Hospital, Changchun 130062, China., Yu L; State Key Laboratory of Human-Animal Zoonotic infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Department of Infectious Diseases, Department of Endocrinology, Department of Interventional Therapy of First Hospital of Jilin University, Changchun 130062, China. Electronic address: yu_lu@jlu.edu.cn.

Publikováno v: International journal of biological macromolecules [Int J Biol Macromol] 2022 Feb 15; Vol. 198, pp. 1-10. Date of Electronic Publication: 2021 Dec 25.