Zobrazeno 1 - 10
of 2 111
pro vyhledávání: '"THERAPEUTIC VACCINE"'
Publikováno v:
Exploration of Digestive Diseases, Vol 3, Iss 6, Pp 443-458 (2024)
Hepatitis B virus (HBV) infection affects 262 million people worldwide, leading to over 820,000 deaths annually. The reason HBV has been a persistent issue for decades is that it is a non-cytopathic, liver-specific virus with the ability for persiste
Externí odkaz:
https://doaj.org/article/49096cf49fa44c098cda33bffdfda498
Autor:
Maryam Moazami Goodarzi, Ghasem Mosayebi, Ali Ganji, Ehsan Raoufi, Samira Sadelaji, Saeid Babaei, Hamid Abtahi
Publikováno v:
BMC Biotechnology, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Human papillomavirus type 16 (HPV-16) infection is strongly associated with considerable parts of cervical, neck, and head cancers. Performed investigations have had moderate clinical success, so research to reach an efficient vac
Externí odkaz:
https://doaj.org/article/491d44e454534a9380dad65795f0e4ab
Autor:
Patricia Gita Naully, Marselina Irasonia Tan, Agustiningsih Agustiningsih, Caecilia Sukowati, Ernawati Arifin Giri-Rachman
Publikováno v:
Annals of Hepatology, Vol 30, Iss 1, Pp 101533- (2025)
Chronic hepatitis B virus infection (CHB) remains a global health concern, with currently available antiviral therapies demonstrating limited effectiveness in preventing hepatocellular carcinoma (HCC) development. Two primary challenges in CHB treatm
Externí odkaz:
https://doaj.org/article/6bd2f4df41414c07bbde50ddf03e04b3
Autor:
Quanlan Fu, Yuandong Luo, Junjie Li, Pingping Zhang, Shuxian Tang, Xinyi Song, Jiawei Fu, Mengqi Liu, Rongmi Mo, Ming Wei, Hejie Li, Xiaosong Liu, Tianfang Wang, Guoying Ni
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Cancer remains a major global health challenge. Immunotherapy has revolutionized the management of cancer, yet only a limited number of patients respond to such treatments. This is largely attributed to the immunosuppressive tumor microenvironment, w
Externí odkaz:
https://doaj.org/article/2cf9809c19ac4dd58beb724a6d8729b5
Autor:
E. A. Khromova, M. P. Kostinov, S. A. Skhodova, V. N. Osiptsov, I. V. Bisheva, D. V. Pakhomov, E. A. Kurbatova, A. A. Khasanova, N. O. Kryukova, M. N. Shatokhin
Publikováno v:
Медицинская иммунология, Vol 26, Iss 2, Pp 355-366 (2024)
Cellular immunity plays an important role in the control of SARS-CoV-2. Lymphopenia and a decrease in the functional activity of cells may be among the main reasons for deterioration of clinical outcomes of the disease. Usage of the bacterial therape
Externí odkaz:
https://doaj.org/article/0bbe0beb4eb24666a4c14639c61a3e72
Publikováno v:
Taiwanese Journal of Obstetrics & Gynecology, Vol 63, Iss 1, Pp 22-28 (2024)
Cervical cancer and its precursor lesion, cervical intraepithelial neoplasia (CIN), are caused by high-risk human papillomavirus (HPV) viral infection and are highly susceptible to host immunity targeting of HPV viral proteins, which include both for
Externí odkaz:
https://doaj.org/article/ec927081776b420a840bc5e8f90a5840
Autor:
Jéssica L. Chechi, Felipe A. C. da Costa, Julia M. Figueiredo, Cássia M. de Souza, Alessandro F. Valdez, Daniel Zamith-Miranda, Aline C. Camara, Carlos P. Taborda, Joshua D. Nosanchuk
Publikováno v:
Expert Review of Vaccines, Vol 22, Iss 1, Pp 1136-1153 (2023)
ABSTRACTIntroduction Fungal infections are caused by a broad range of pathogenic fungi that are found worldwide with different geographic distributions, incidences, and mortality rates. Considering that there are relatively few approved medications a
Externí odkaz:
https://doaj.org/article/a5f91ceada72428b90589862c5045897
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Dendritic cell (DC)-based vaccines have emerged as a promising strategy in cancer immunotherapy due to low toxicity. However, the therapeutic efficacy of DC as a monotherapy is insufficient due to highly immunosuppressive tumor environment. To addres
Externí odkaz:
https://doaj.org/article/f2de24b2780a435eaacd8ee19b25d1bf
Autor:
Jinpeng Su, Zahra Harati Taji, Anna D. Kosinska, Edanur Ates Oz, Zhe Xie, Pavlo Bielytskyi, Mikhail Shein, Philipp Hagen, Shohreh Esmaeili, Katja Steiger, Ulrike Protzer, Anne K. Schütz
Publikováno v:
JHEP Reports, Vol 6, Iss 4, Pp 100997- (2024)
Background & Aims: Particulate hepatitis B core antigen (HBcoreAg) is a potent immunogen used as a vaccine carrier platform. HBcoreAg produced in E. coli encapsidates random bacterial RNA (bRNA). Using the heterologous protein-prime, viral-vector-boo
Externí odkaz:
https://doaj.org/article/f0879e7c303e4f3bbb4b61d82f789e2c
Autor:
Chel Hun Choi, Jeong-Won Lee, Duk-Soo Bae, Eun-Suk Kang, Duck Cho, Yong-Man Kim, Kidong Kim, Jae-Weon Kim, Hee Seung Kim, Young-Tae Kim, Jung-Yun Lee, Myong Cheol Lim, Taegwon Oh, Boyeong Song, Insu Jeon, Myunghwan Park, Wu Hyun Kim, Chang-Yuil Kang, Byoung-Gie Kim
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundBVAC-C, a B cell– and monocyte-based immunotherapeutic vaccine transfected with recombinant HPV E6/E7, was well tolerated in HPV–positive recurrent cervical carcinoma patients in a phase I study. This phase IIa study investigates the an
Externí odkaz:
https://doaj.org/article/25f6fbb234fe45fb87de005ce22849a5