Zobrazeno 1 - 10
of 523
pro vyhledávání: '"TGFB"'
Autor:
Moslem Javidan, Amir Mohamad Amiri, Narges Koohi, Nazanin Joudaki, Mohammad Ali Bashirrohelleh, Ali Pirsadeghi, Ali Farhadi Biregani, Mohammad Rashno, Mohammad Ghasemi Dehcheshmeh, Moosa Sharifat, Ali Khodadadi, Ladan Mafakher
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116983- (2024)
The induction of immunological tolerance is a promising strategy for managing autoimmune diseases, allergies, and transplant rejection. Tregitopes, a class of peptides, have emerged as potential agents for this purpose. They activate regulatory T cel
Externí odkaz:
https://doaj.org/article/5d9ef44c573c46a09016446a34855c3e
Autor:
Haley R Noonan, Alexandra M Thornock, Julia Barbano, Michael E Xifaras, Chloe S Baron, Song Yang, Katherine Koczirka, Alicia M McConnell, Leonard I Zon
Publikováno v:
eLife, Vol 13 (2024)
Developmental signaling pathways associated with growth factors such as TGFb are commonly dysregulated in melanoma. Here we identified a human TGFb enhancer specifically activated in melanoma cells treated with TGFB1 ligand. We generated stable trans
Externí odkaz:
https://doaj.org/article/f51748881cd9498bbfd7139601c881b1
Autor:
Yao Wang, Enrico Cortes, Ricky Huang, Jeremy Wan, Junyi Zhao, Boris Hinz, Robert Damoiseaux, Ivan Pushkarsky
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100138- (2024)
The pivotal role of myofibroblast contractility in the pathophysiology of fibrosis is widely recognized, yet HTS approaches are not available to quantify this critically important function in drug discovery. We developed, validated, and scaled-up a H
Externí odkaz:
https://doaj.org/article/9fd84433bdee47a59fce51d80d3b7468
Autor:
Patrick Treat Paine, Cheyenne Rechsteiner, Francesco Morandini, Gabriela Desdín-Micó, Calida Mrabti, Alberto Parras, Amin Haghani, Robert Brooke, Steve Horvath, Andrei Seluanov, Vera Gorbunova, Alejandro Ocampo
Publikováno v:
Frontiers in Aging, Vol 4 (2024)
Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The conferment of
Externí odkaz:
https://doaj.org/article/3cf34d95781547ddadab3e678f935ae3
Autor:
Zaniya A. Mark, Linda Yu, Lysandra Castro, Xiaohua Gao, Noelle R. Rodriguez, Deloris Sutton, Erica Scappini, Charles J. Tucker, Rob Wine, Yitang Yan, Evangeline Motley, Darlene Dixon
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4902 (2024)
High-risk human papillomavirus (HR-HPV; HPV-16) and cigarette smoking are associated with cervical cancer (CC); however, the underlying mechanism(s) remain unclear. Additionally, the carcinogenic components of tobacco have been found in the cervical
Externí odkaz:
https://doaj.org/article/f0e026734b7c443983bb02a139b3b7a6
Publikováno v:
Cells, Vol 13, Iss 7, p 626 (2024)
(1) Background: Our previous data indicated that disturbance of the Transforming Growth Factor beta (TGFB) signaling pathway via its Type-2 Receptor (TGFBR2) can cause a Corneal Ectasia (CE)-like phenotype. The purpose of this study is to elucidate w
Externí odkaz:
https://doaj.org/article/041cacb55d3046ab967f55cfd5acdc51
Autor:
Patrik Simmler, Eleonora I Ioannidi, Tamara Mengis, Kim Fabiano Marquart, Simran Asawa, Kjong Van-Lehmann, Andre Kahles, Tinu Thomas, Cornelia Schwerdel, Nicola Aceto, Gunnar Rätsch, Markus Stoffel, Gerald Schwank
Publikováno v:
eLife, Vol 12 (2023)
The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). The impact of the hotspot mutation SF3B1K700E on the PDAC pathogenesis, however, remains elusive. Here, we demonstrate that Sf3b1K7
Externí odkaz:
https://doaj.org/article/60ac28afd80545779ac04224dc960954
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune funct
Externí odkaz:
https://doaj.org/article/c54c17d16b7948e2b8421793bbb91110