Výsledky vyhledávání - "TGF-beta signaling cascade"

TGF-β1 in plasma and cerebrospinal fluid can be used as a biological indicator of chronic pain in patients with osteoarthritis

Autor: Yen-Chin Liu, Hung-Tsung Hsiao, Jeffrey Chi-Fei Wang, Tzu-Cheng Wen, Shiou-Lan Chen

Publikováno v: PLoS ONE
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262074 (2022)

Introduction Previous studies have demonstrated that cytokines, transforming growth factor (TGF-β1), and brain-derived neurotrophic factor (BDNF) can impact the intensity of pain in rodents. However, the roles of cytokines, TGF-β1 and BDNF in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f49026db08d53195f3786e1365cd54
http://europepmc.org/articles/PMC8782532

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Physical exercise is associated with a reduction in plasma levels of fractalkine, TGF-β1, eotaxin-1 and IL-6 in younger adults with mobility disability

Autor: Parvin Kumar, Miranda Stiernborg, Anna Fogdell-Hahn, Kristoffer Månsson, Tomas Furmark, Daniel Berglind, Philippe A. Melas, Yvonne Forsell, Catharina Lavebratt

Publikováno v: PLoS ONE, Vol 17, Iss 2, p e0263173 (2022)
PLoS ONE

Mobility disability (MD) refers to substantial limitations in life activities that arise because of movement impairments. Although MD is most prevalent in older individuals, it can also affect younger adults. Increasing evidence suggests that inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43b80fa1c4e1943cc3bc1ff986b79d1
https://doaj.org/article/980a2ed646b34c78a8c769d223f3448c

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Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve

Autor: Arnaud Chignon, Déborah Argaud, Marie-Chloé Boulanger, Ghada Mkannez, Valentin Bon-Baret, Zhonglin Li, Sébastien Thériault, Yohan Bossé, Patrick Mathieu

Publikováno v: PLoS Genetics, Vol 18, Iss 1, p e1010010 (2022)
PLoS Genetics

Calcific aortic valve disease (CAVD) is characterized by a fibrocalcific process. The regulatory mechanisms that drive the fibrotic response in the aortic valve (AV) are poorly understood. Long noncoding RNAs derived from super-enhancers (lncRNA-SE)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d5c5292deeb8a29800ed4f469475cd
https://doaj.org/article/a52b63d858e342a38c2ef01cec081680

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The involvement of TGF-β1 /FAK/α-SMA pathway in the antifibrotic impact of rice bran oil on thioacetamide-induced liver fibrosis in rats

Autor: Rehab F. Abdel-Rahman, Hany M. Fayed, Gihan F. Asaad, Hanan A. Ogaly, Alyaa F. Hessin, Abeer A. A. Salama, Sahar S. Abd El-Rahman, Mahmoud S. Arbid, Marawan Abd Elbaset Mohamed

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0260130 (2021)

The objective of the current study is to investigate the effect of rice bran oil (RBO) on hepatic fibrosis as a characteristic response to persistent liver injuries. Rats were randomly allocated into five groups: the negative control group, thioaceta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa903f042b9f3d0db84dc978304eade0
https://pubmed.ncbi.nlm.nih.gov/34965258

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Expression and role of lumican in acute aortic dissection: A human and mouse study

Autor: Ming-En Hsu, Chien-Te Ho, Victor Chien-Chia Wu, Ying-Chang Tung, Winston W.-Y. Kao, Shao-Wei Chen, Pao-Hsien Chu, Fu-Chih Hsiao, Shing-Hsien Chou, Yi-Hsin Chan, An-Hsun Chou, Pyng-Jing Lin

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0255238 (2021)

Introduction Aortic dissection (AD) is a life-threatening emergency, and lumican (LUM) is a potential Biomarker for AD diagnosis. We investigated LUM expression patterns in patients with AD and explored the molecular functions of Lum in AD mice model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50bffa71013b469d1ef7695307cbf02c
http://europepmc.org/articles/PMC8312931

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CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression

Autor: Scott J. Neal, Dae-Won Kim, Piali Sengupta, Hye-Kyoung Oh, Do-Young Kim, Yeon-Ji Park, YongJin Cheon, Abdul Rouf Dar, Jisoo Park, Hyeonjeong Hwang, Rebecca A. Butcher, Kyuhyung Kim

Publikováno v: PLoS Genetics, Vol 17, Iss 7, p e1009678 (2021)
PLoS Genetics

Animals can adapt to dynamic environmental conditions by modulating their developmental programs. Understanding the genetic architecture and molecular mechanisms underlying developmental plasticity in response to changing environments is an important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6ebc0b18ae999fd835b0abc1a31291
https://doaj.org/article/ab94ee1c1b4a455fa7c93a412714ed8a

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1,8 Cineole and Ellagic acid inhibit hepatocarcinogenesis via upregulation of MiR-122 and suppression of TGF-β1, FSCN1, Vimentin, VEGF, and MMP-9

Autor: Heba M. I. Abdallah, Sally A. El Awdan, Rehab F. Abdel-Rahman, Abdel Razik H. Farrag, Rasha M. Allam

Publikováno v: PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0258998 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)

Hepatocellular carcinoma (HCC) is one of the most burdened tumors worldwide, with a complex and multifactorial pathogenesis. Current treatment approaches involve different molecular targets. Phytochemicals have shown considerable promise in the preve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc081194f4c79d5dd103a24b6ff3a569
https://pubmed.ncbi.nlm.nih.gov/35081125

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MiRNA-107 enhances the malignant progression of pancreatic cancer by targeting TGFBR3

Autor: Cuijuan Zhang, Tingke Tian, Xiaokun Li, Quanzhong Yang, Jiancheng Cheng

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0249375 (2021)

Background The prognosis of pancreatic cancer (PC) is relatively dismal due to the lack of effective therapy. In this study, we explored the specific functions and molecular mechanisms of miR-107 to uncover effective therapeutic targets for PC. Metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dedee43f3839bc5fdc154d2391657f7
http://europepmc.org/articles/PMC8133469

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