Zobrazeno 1 - 10
of 315
pro vyhledávání: '"TGF-β1/Smad3"'
Autor:
Juan Wang, Zhenkun Xia, Bei Qing, Ying Chen, Linguo Gu, Hongzuo Chen, Zhenglian Ge, Yunchang Yuan
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)
Abstract Background Pulmonary fibrosis (PF) is a progressive and difficult-to-heal lung disease that poses a significant threat to human life and health. This study aimed to investigate the potential pathological mechanisms of PF and to identify new
Externí odkaz:
https://doaj.org/article/5394b2a805634082aa96d47f95a27e63
Publikováno v:
陆军军医大学学报, Vol 46, Iss 18, Pp 2110-2120 (2024)
Objective To investigate the effect of glycine N-methyl transferase (GNMT) on intrauterine adhesion (IUA) fibrosis and its related mechanism. Methods In vivo experiment: A total of 36 healthy female SD rats (SPF grade, 6~8 weeks old and weighing from
Externí odkaz:
https://doaj.org/article/5f97367e51e94aefbf8603125845e62e
Autor:
Lan Chen, Caixia Kong
Publikováno v:
Gynecological Endocrinology, Vol 40, Iss 1 (2024)
Background Polycystic ovarian syndrome (PCOS) is a prevalent metabolic and endocrine condition in females of reproductive age. This work was to discover the underlying role of Dickkopf 1 (DKK1) and its putative regulating mechanism in P COS.Methods M
Externí odkaz:
https://doaj.org/article/5ef9ed74d5e847dfaabe9bd014a0d2c2
Autor:
Ke Xu, Yunyi Wang, Xiao Gao, Zhaolan Wei, Qi Han, Shuxin Wang, Wanting Du, Jian Wan, Cuihong Wan, Mingqing Chen
Publikováno v:
Environmental Science and Ecotechnology, Vol 22, Iss , Pp 100471- (2024)
Microplastics and phthalates are prevalent and emerging pollutants that pose a potential impact on human health. Previous studies suggest that both microplastics and phthalates can adversely affect the reproductive systems of humans and mammals. Howe
Externí odkaz:
https://doaj.org/article/ee649890898b4a64a93c73e7af3352e0
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-12 (2024)
Abstract Joint contracture is one of the common diseases clinically, and joint capsule fibrosis is considered to be one of the most important pathological changes of joint contracture. However, the underlying mechanism of joint capsule fibrosis is st
Externí odkaz:
https://doaj.org/article/7e4cddea11d0411ca9f8663727ec06eb
Autor:
Fuqiang Yao, Minghao Xu, Lingjun Dong, Xiao Shen, Yujie Shen, Yisheng Jiang, Ting Zhu, Chu Zhang, Guangmao Yu
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Background Since COVID-19 became a global epidemic disease in 2019, pulmonary fibrosis (PF) has become more prevalent among persons with severe infections, with IPF being the most prevalent form. In traditional Chinese medicine, various diso
Externí odkaz:
https://doaj.org/article/6d6f1f0436c84e42a7c4409d1f5112a8
Publikováno v:
康复学报, Vol 33, Pp 528-534 (2023)
ObjectiveTo explore the effect of long non-coding RNA H19 (lncRNA H19) and microRNA (miRNA)-200a on cardiac function and myocardial fibrosis in rats with chronic heart failure based on transforming growth factor-β1 (TGF-β1)/Smad homolog 3 (Smad3) s
Externí odkaz:
https://doaj.org/article/32f09d774ab545a89564f85c8a61f2f6
Autor:
Chunyan He, Lei Gu, Anmao Li, Yishi Li, Rui Xiao, Jiaxin Liao, Junhao Mu, Yiling Gan, Mingyu Peng, Giri Mohan, Wei Liu, Li Xu, Shuliang Guo
Publikováno v:
Molecular and Cellular Probes, Vol 73, Iss , Pp 101947- (2024)
Airway fibrosis is among the pathological manifestations of benign central airway obstruction noted in the absence of effective treatments and requires new drug targets to be developed. Slit guidance ligand 2–roundabout guidance receptor 1 (Slit2
Externí odkaz:
https://doaj.org/article/93a1cb95e7ec48248f68ad16e486388a
CLC-3 regulates TGF-β/smad signaling pathway to inhibit the process of fibrosis in hypertrophic scar
Autor:
Qian Liang, Fuqiang Pan, Houhuang Qiu, Xiang Zhou, Jieyun Cai, Ruijin Luo, Zenghui Xiong, Huawei Yang, Liming Zhang
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e24984- (2024)
Objective: To study the role and mechanism of chloride channel-3 (ClC-3) in the formation of hypertrophic scar by constructing ClC-3 interference vectors and examining their effects on human hypertrophic scar fibroblasts (HSFB). Methods: Human HSFB a
Externí odkaz:
https://doaj.org/article/ca8cd93abba642d6a1830cbcee1e15d7
Publikováno v:
Open Medicine, Vol 18, Iss 1, Pp 1-13 (2023)
Heart failure (HF) is a major global cause of morbidity and mortality. This study aimed to elucidate the role of secreted protein acidic and rich in cysteine-related modular calcium-binding protein 2 (SMOC2) in HF development and its underlying mecha
Externí odkaz:
https://doaj.org/article/105448e623b74f598fb55295ae415168