ALMS1 Regulates TGF-β Signaling and Morphology of Primary Cilia

Autor: María Álvarez-Satta, Mauro Lago-Docampo, Brais Bea-Mascato, Carlos Solarat, Sheila Castro-Sánchez, Søren T. Christensen, Diana Valverde

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

In this study, we aimed to evaluate the role of ALMS1 in the morphology of primary cilia and regulation of cellular signaling using a knockdown model of the hTERT-RPE1 cell line. ALMS1 depletion resulted in the formation of longer cilia, which often

Externí odkaz: https://doaj.org/article/2d1838e82c63439eb0ccef885435e330

Myhre Syndrome Associated With Dunbar Syndrome and Urinary Tract Abnormalities: A Case Report

Autor: Zofia Varenyiova, Gabriela Hrckova, Denisa Ilencikova, Ludmila Podracka

Publikováno v: Frontiers in Pediatrics, Vol 8 (2020)

Myhre syndrome is a rare condition caused by a mutation in the SMAD4 gene, which leads to a defective TGF-β/BMP signaling, resulting in the proliferation of abnormal fibrous tissues. Clinically, patients with Myhre syndrome manifest with defects of

Externí odkaz: https://doaj.org/article/2dbf8beed8654308a5e3fc342b5068b4

Activity of Smurf2 Ubiquitin Ligase Is Regulated by the Wnt Pathway Protein Dishevelled

Autor: Ondrej Bernatik, Petra Paclikova, Ranjani Sri Ganji, Vitezslav Bryja

Publikováno v: Cells, Vol 9, Iss 5, p 1147 (2020)

Wnt and BMP signaling pathways are two key molecular machineries regulating development and homeostasis. The efficient coordination of Wnt and BMP is essential in many developmental processes such as establishment of antero-posterior and dorso-ventra

Externí odkaz: https://doaj.org/article/aa36928582a94000befbaaf93de26ba2

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Concurrent BMP signalling maintenance and TGF-β signalling inhibition is a hallmark of natural resistance to muscle atrophy in the hibernating bear

Autor: Elise Gueret, Stéphane Blanc, Emmanuelle Meugnier, Etienne Lefai, Cécile Polge, Chantal Simon, Guillemette Gauquelin-Koch, Charlotte Brun, Laura Cussonneau, Alina L. Evans, Fabrice Bertile, Daniel Béchet, Jon M. Arnemo, Christian Boyer, Lydie Combaret, Daniel Taillandier, Christiane Deval, Emmanuelle Loizon, Jon E. Swenson, Emeric Dubois

Publikováno v: Cells
Cells, MDPI, 2021, 10 (8), pp.1873. ⟨10.3390/cells10081873⟩
Cells, Vol 10, Iss 1873, p 1873 (2021)
Volume 10
Issue 8
Cells, 2021, 10 (8), pp.1873. ⟨10.3390/cells10081873⟩

International audience; Muscle atrophy arises from a multiplicity of physio-pathological situations and has very detrimental consequences for the whole body. Although knowledge of muscle atrophy mechanisms keeps growing, there is still no proven trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc65bbe5b7dafb712d3bc67e03d3ffd
https://hdl.handle.net/11250/2999604