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pro vyhledávání: '"TGF beta receptor 2"'
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Publikováno v:
Applied Numerical Mathematics. 133:41-51
Mammalian cells respond in a variety of ways to concentrations of activated transforming growth factor (TGF) in the extracellular domain via intracellular Smad signaling pathways. TGF-β/Smad interaction is prevalent in a wide range of tumor environm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b55c22211fa7e8353da46aa80e7a435
https://doi.org/10.1016/j.apnum.2017.11.004
https://doi.org/10.1016/j.apnum.2017.11.004
Autor:
Koichiro Mihara, Frank Gieseler, David Witte, Morley D. Hollenberg, Hendrik Lehnert, Petra Henklein, Bernhard H. Rauch, Hendrik Ungefroren, Shirin Bonni, Roland Kaufmann, Olaf Jöhren, Utz Settmacher
Publikováno v:
Molecular Pharmacology. 92:519-532
Transforming growth factor-β (TGF-β), serine proteinases such as trypsin, and proteinase-activated receptor 2 (PAR2) promote tumor development by stimulating invasion and metastasis. Previously, we found that in cancer cells derived from pancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b389ca122f16e3e6e398773bf46e1aef
https://doi.org/10.1124/mol.117.109017
https://doi.org/10.1124/mol.117.109017
Autor:
Bin Yang, Ke Jin, Jin Jin, Yifei Tu, Yihao Li, Steven Dooley, Junling Jia, Fangfang Zhou, Yao Fan, Long Zhang, Honglei Weng, Shuai Wang, Feng Xie, Peter ten Dijke, Li Shao, Hans van Dam
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications, 8
Nature Communications
Nature Communications, 8
TGF-β is pro-metastatic for the late-stage breast cancer cells. Despite recent progress, the regulation of TGF-β type II receptor remains uncertain. Here we report that FAF1 destabilizes TβRII on the cell surface by recruiting the VCP/E3 ligase co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a56e37e5f9272ca386835a303cf467f
https://doaj.org/article/c9d75b7c3d6a4d48b6838665b721268c
https://doaj.org/article/c9d75b7c3d6a4d48b6838665b721268c
Autor:
Daniel R. Higazi, Michael A. Bowen, Nicholas J. Bond, Rebecca Dunmore, Lynne Murray, William Dall'acqua, Yanli Wu, Jie Zhu, Toyin Kasali, M. Jack Borrok, Lena Shirinian, Arnita Barnes, Catherine Huntington, Sandrina Phipps, John Hood, Emilie Solier, Ping Tsui, Keith W Rickert, Alan M. Carruthers
Publikováno v:
mAbs. 9:104-113
Excessive transforming growth factor (TGF)-β is associated with pro-fibrotic responses in lung disease, yet it also plays essential roles in tissue homeostasis and autoimmunity. Therefore, selective inhibition of excessive and aberrant integrin-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d570ca136c988614413eb835598fa70
https://doi.org/10.1080/19420862.2016.1255390
https://doi.org/10.1080/19420862.2016.1255390
Autor:
Kazuhiko Fujita, Osamu Kozawa, Haruhiko Tokuda, Rie Matsushima-Nishiwaki, Gen Kuroyanagi, Takanobu Otsuka, Naohiro Yamamoto, Shingo Kainuma
Publikováno v:
Molecular and Cellular Endocrinology. 436:1-9
Heat shock proteins (HSPs) are induced in response to various physiological and environmental conditions such as chemical and heat stress, and recognized to function as molecular chaperones. HSP22 (HSPB8), a low-molecular weight HSP, is ubiquitously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd7892dadd0bb2dabdd744de8db9f3f
https://doi.org/10.1016/j.mce.2016.07.011
https://doi.org/10.1016/j.mce.2016.07.011
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Fibrosis is an ominous pathological process in failing myocardium, but its pathogenesis is poorly understood. We recently reported that loss of an extracellular matrix (ECM) protein, fibulin-2, protected against ventricular dysfunction after myocardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c44120998406c871a3c40bbdeb1d7d
https://doi.org/10.1038/labinvest.2016.52
https://doi.org/10.1038/labinvest.2016.52
Autor:
Bhamini Vaidialingam, Michael Franti, Priyanka Gupta, Neil A. Farrow, Anil Kumar Padyana, David B. Hayes
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 72:160-164
Members of the TGF-β family of proteins are believed to play critical roles in cellular signaling processes such as those involved in muscle differentiation. The extent to which individual family members have been characterized and linked to biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30406ef1dc909ef7de92344196cc591
https://doi.org/10.1107/s2053230x16001588
https://doi.org/10.1107/s2053230x16001588
Publikováno v:
Molecular Neurobiology. 54:964-976
Transforming growth factor-alpha (TGF-α) is known to play multifunctional roles in the central nervous system (CNS), including the provision of neurotropic properties that protect neurons against various neurotoxic insults. Previously, we reported t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51812e54bcc2066e17c8b6a03ce919dc
https://doi.org/10.1007/s12035-016-9705-9
https://doi.org/10.1007/s12035-016-9705-9
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Rapamycin, the macrolide immunosuppressant and active pharmaceutic in drug-eluting stents (DES), has a well-recognized antiproliferative action that involves inhibition of the mTOR pathway after binding to the cytosolic protein FKBP12. TGF receptor-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a59e664c3b52b533bd44d67222435c
