Zobrazeno 1 - 10
of 1 738
pro vyhledávání: '"TGFβ1"'
Autor:
Xiaobo Zhu, Mingde Cao, Kejia Li, Yau-Tsz Chan, Hon-Fai Chan, Yi-Wah Mak, Hao Yao, Jing Sun, Michael Tim-Yun Ong, Kevin Ki-Wai Ho, Chien-Wei Lee, Oscar Kuang-Sheng Lee, Patrick Shu-Hang Yung, Yangzi Jiang
Publikováno v:
Bioactive Materials, Vol 39, Iss , Pp 255-272 (2024)
Osteoarthritis (OA) is a major clinical challenge, and effective disease-modifying drugs for OA are still lacking due to the complicated pathology and scattered treatment targets. Effective early treatments are urgently needed to prevent OA progressi
Externí odkaz:
https://doaj.org/article/65efe12f07f7452db3d7098879962681
Publikováno v:
Metabolism Open, Vol 23, Iss , Pp 100316- (2024)
Diabetic Nephropathy (DN) has become the leading cause of end-stage renal disease worldwide. Studies have indicated that Transforming Growth Factor beta1 (TGFβ1) is the most potent factor contributing to renal fibrosis, and understanding the exact p
Externí odkaz:
https://doaj.org/article/70aec13d63204457884e2e7833e5e76d
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101807- (2024)
The fate and stability of messenger RNA (mRNA), from transcription to degradation is regulated by a dynamic shuttle of epigenetic modifications and RNA binding proteins in maintaining healthy cellular homeostasis and disease development. While Transf
Externí odkaz:
https://doaj.org/article/54cff313593c475398c3737930d5f897
Autor:
Ziwei Wang, Hehua Zhao
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35444- (2024)
Pulmonary fibrosis is a severe and progressive lung disease characterized by the abnormal accumulation of extracellular matrix, leading to scarring and loss of normal lung function. Recent bioinformatics analysis through the Gene Expression Omnibus (
Externí odkaz:
https://doaj.org/article/ee549762c25d429697e5d9198789afc7
Autor:
Fang Zhou, He-Ya Qian, Ke Wang, Yong-Juan Gu, Pei-Lin Liu, Ling Zhang, Long Chen, Yu Song, Ya-Nan Chen, Hai-Long Zhang
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e34991- (2024)
Common cancer complications include bone cancer pain (BCP), which was not sufficiently alleviated by traditional analgesics. More safe and effective therapy was urgent needed. Metformin relieved osteoarthritis pain, but the analgesia of Metformin in
Externí odkaz:
https://doaj.org/article/efbca2f99c8c468490b00dccfc057902
Autor:
Mingting Wu, Zhenyan Wang, Xiaoqian Shi, Danni Zan, Hong Chen, Shuqiao Yang, Fangping Ding, Liu Yang, Pingping Tan, Runlin Z. Ma, Jing Wang, Lishuang Ma, Yingmin Ma, Jiawei Jin
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is required to develop alternative therapeutic strategies. Methods The l
Externí odkaz:
https://doaj.org/article/6783bca8af394f65b4d47655f75cd68f
Autor:
Jinrui Sun, Ruicheng Yang, Jiyang Fu, Dong Huo, Xinyi Qu, Chen Tan, Huanchun Chen, Xiangru Wang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Meningitic Escherichia coli (E. coli) is the major etiological agent of bacterial meningitis, a life-threatening infectious disease with severe neurological sequelae and high mortality. The major cause of central nervous system (C
Externí odkaz:
https://doaj.org/article/97fbb1913a2d4ba7ba9e2850aebaca3a
Autor:
Sebastian Kubica, Justyna Szota-Czyż, Barbara Strzałka-Mrozik, Jolanta Adamska, Ewa Bębenek, Elwira Chrobak, Joanna Magdalena Gola
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9961-9975 (2023)
Betulin derivatives are proposed to serve as an alternative to the drugs already established in oncologic treatment. Drug-induced nephrotoxicity leading to acute kidney injury frequently accompanies cancer treatment, and thus there is a need to resea
Externí odkaz:
https://doaj.org/article/cf6017dc59934d97a4c3d31d4c18c742
Autor:
Nadine Altmann, Charles Bowlby, Haley Coughlin, Zarah Belacic, Stasia Sullivan, Sushmitha Durgam
Publikováno v:
BMC Musculoskeletal Disorders, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background Prolonged inflammation during tendon healing and poor intrinsic healing capacity of tendon are causal factors associated with tendon structural and functional degeneration. Tendon cells, consisting of mature tenocytes and tendon p
Externí odkaz:
https://doaj.org/article/0c5cb2c48f6940a0ae15026a28c957d9
Publikováno v:
Journal of Ophthalmology, Iss 4, Pp 26-33 (2023)
Background: Age-related macular degeneration (AMD) is one of the most common disorders that can lead to total central vision loss after choroidal neovascularization or geographic atrophy (GA). Because the genetic component of the disease plays an imp
Externí odkaz:
https://doaj.org/article/38e6039581174d1bbf800d00e3c86ed3