Zobrazeno 1 - 10
of 43
pro vyhledávání: '"TGFβ/Smad pathway"'
Akademický článek
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Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Abstract Background Adult hippocampal neurogenesis (AHN) is restricted under the pathological conditions of neurodegenerative diseases, especially in Alzheimer’s disease (AD). The drop of AHN reduces neural circuit plasticity, resulting in the decr
Externí odkaz:
https://doaj.org/article/7120c9a5798c445cbfbced468a2c7396
Autor:
Yogender Shokeen, Neeta Raj Sharma, Abhishek Vats, Veronique Dinand, Mirza Adil Beg, Satish Sanskaran, Sachin Minhas, Mayank Jauhri, Arun K Hariharan, Vibha Taneja, Shyam Aggarwal
Publikováno v:
International Journal of Hematology-Oncology and Stem Cell Research, Vol 12, Iss 1 (2018)
Background: Chronic myeloid leukemia (CML) is a hematological disorder caused by fusion of BCR and ABL genes. BCR-ABL dependent and independent pathways play equally important role in CML. TGFβ-Smad pathway, an important BCR -ABL independent pathway
Externí odkaz:
https://doaj.org/article/853aa3b4db9c4eff901d7a23af941a75
Publikováno v:
Molecules, Vol 23, Iss 7, p 1644 (2018)
A series of novel matrinic thiadiazole derivatives were designed, synthesized and evaluated for their inhibitory effect on COL1A1 promotor. The SAR indicated that: (i) the introduction of a thiadiazole on the 11-side chain was beneficial for activity
Externí odkaz:
https://doaj.org/article/5a5d9a85e2c64f8791a083588a88ef1d
Publikováno v:
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Background Adult hippocampal neurogenesis (AHN) is restricted under the pathological conditions of neurodegenerative diseases, especially in Alzheimer’s disease (AD). The drop of AHN reduces neural circuit plasticity, resulting in the decrease of t
Publikováno v:
Therapeutic Advances in Chronic Disease, Vol 12 (2021)
Therapeutic Advances in Chronic Disease
Therapeutic Advances in Chronic Disease
Aims: In this study, we aimed to decipher the impact of enhancer of zeste homolog 2 (EZH2) in psoriasis as well as the underlying mechanism. Methods: A mouse model of psoriasis was developed by means of imiquimod induction, with the expression of EZH
Autor:
Giuseppe Attanasio, Marco Marenco, Fabiana Mallone, Rocco Plateroti, Roberta Costi, Antonio Minni, Marco Artico, Alessandro Lambiase
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11748, p 11748 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Ocular fibrosis leads to severe visual impairment and blindness worldwide, being a major area of unmet need in ophthalmology and medicine. To date, the only available treatments are antimetabolite drugs that have significant potentially blinding side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977dff1000c80e4da56224aa58e628cf
http://hdl.handle.net/11573/1594159
http://hdl.handle.net/11573/1594159
Autor:
Jingwen Lu, Yue Zhang, Xing-Xing Zhang, Jin-Lian Chen, Yun Lu, Xin Xing, Hua Chen, Nvshi Zhou
Publikováno v:
International Journal of Molecular Medicine
Recent studies have reported that the expression levels of far upstream element‑binding protein 1 (FUBP1) were upregulated and served a crucial role in several types of cancer. However, the underlying molecular mechanisms and clinical significance
Autor:
Jingqi Shi, Lianhe Zheng, Shuya Yang, Liang Tao, Boquan Jin, Yuanjie Sun, Erle Dang, Zichao Li, Kun Yang, Jiayi Zhou, Jun Wang, Dongbo Jiang, Jing Wang, Yuchen Lu
Publikováno v:
Cancer Medicine
BAP31 (B‐cell receptor‐associated protein 31) is an important regulator of intracellular signal transduction and highly expressed in several cancer tissues or testicular tissues. Our previous study had revealed that elevated BAP31 plays a crucial
Akademický článek
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