Zobrazeno 1 - 10
of 70
pro vyhledávání: '"TG, transgenic"'
Autor:
Anagha Krishna, Thaddeus S. Stappenbeck, Xiaohua Jin, Ron Bose, Elisa M. Murray, Takahiro E. Ohara, Xiaoqing Cheng
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1105-1120 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1105-1120 (2021)
Background and Aims The Cancer Genome Atlas (TCGA) project has identified HER2 mutations or amplification in 7% of colon cancers. In addition to HER2 mutations, colon cancer patients also possess co-occurring mutations in genes such as APC. Here, we
Autor:
Norbert Frey, Lucie Carrier, Franziska Dierck, Frauke Senger, Gabriele Brunke, Christian Kuhn, Nesrin Schmiedel, Ashraf Yusuf Rangrez, Derk Frank, Susanne Hille, Rainer Will, Samuel Sossalla, Maja Menke, Thomas Eschenhagen, Renate Lüllmann-Rauch, Inga Schmidt, Pia Bünger, Claudia Mack
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • FYCO1, a component of the autophagic machinery, is highly expressed in the heart and a potent inducer of cardiomyocyte autophagy. • Loss of FYCO1 in vivo inhibits adaptation to starvation or biomechanical stress
Highlights • FYCO1, a component of the autophagic machinery, is highly expressed in the heart and a potent inducer of cardiomyocyte autophagy. • Loss of FYCO1 in vivo inhibits adaptation to starvation or biomechanical stress
Autor:
Romil Saxena, Wenjie Cai, Yang Zhang, Menghao Huang, Xiaolin Zhong, Kushan Chowdhury, Robert F. Schwabe, Suthat Liangpunsakul, Hyeong-Geug Kim, X. Charlie Dong
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 341-364 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that is manifested clinically by an increase in hepatic triglycerides, inflammation, and fibrosis. The pathogenesis of NASH remains incompletely understood. Sirtuin 6 (S
Autor:
Tomohide Kurahashi, Satoshi Ogura, Takahiro Kodama, Yoshihiro Kamada, I-Ching Wang, Ryotaro Sakamori, Yuichiro Doki, Eiichi Morii, Kunimaro Furuta, Mayumi Egawa, Masaki Mori, Yuichi Yoshida, Hidetoshi Eguchi, Tomohide Tatsumi, Tetsuo Takehara, Shinichi Kiso, Hayato Hikita, Vladimir V. Kalinichenko
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 425-446 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Liver inflammation has been recognized as a hallmark of hepatocarcinogenesis. Although Forkhead Box M1 (FoxM1) is a well-defined oncogenic transcription factor that is overexpressed in hepatocellular carcinoma (HCC), its role in liv
Autor:
Tram Anh Tran, Qing-Jun Zhang, Lei Wang, Christopher Gonzales, Luc Girard, Herman May, Thomas Gillette, Zhi-Ping Liu, Elisabeth D. Martinez
Publikováno v:
The Journal of Biological Chemistry
Hypertrophic/dilated cardiomyopathy, often a prequel to heart failure, is accompanied by maladaptive transcriptional changes that contribute to arrythmias and contractile misfunction. Transgenic mice constitutively expressing high levels of calcineur
Autor:
Tirthadipa Pradhan-Sundd
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1199-1201 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1199-1201 (2021)
Background & Aims cAMP responsive element-binding protein 3 like 3 (CREB3L3) is a membrane-bound transcription factor involved in the maintenance of lipid metabolism in the liver and small intestine. CREB3L3 controls hepatic triglyceride and glucose
Autor:
Aaron J. Donner, Rosanne M. Crooke, Adam E. Mullick, Richard G. Lee, Mingxia Liu, Thomas A. Bell
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100101-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100101-(2021)
Supported by an abundance of experimental and genetic evidence, angiopoietin-like protein 3 (ANGPTL3) has emerged as a promising therapeutic target for cardiovascular disease. ANGPTL3 is primarily produced by the liver and is a potent modulator of pl
Autor:
Seema Singh, Fang Niu, Annadurai Thangaraj, Prakash P. Pillai, Shilpa Buch, Palsamy Periyasamy, Ernest T. Chivero, Minglei Guo, Ashutosh Tripathi
Publikováno v:
Redox Biology, Vol 40, Iss, Pp 101843-(2021)
Redox Biol
Redox Biology
Redox Biol
Redox Biology
The advent of combined antiretroviral treatment (cART) as a treatment for HIV-1 infection has not only resulted in a dramatic decrease in the peripheral viral load but has also led to increased life expectancy of the infected individuals. Paradoxical
Autor:
Hae Li Ko, Kyung Won Kang, Manki Song, Sang-Myeong Lee, Hye-Lim Park, Jae-Ouk Kim, Hye-Jung Kim, Jae-Hwan Nam, Eui-Cheol Shin, Hye Won Kwak, Seung Rok Ryu, Hyo Jung Park, Dae Gwin Jeong, Rhoon-Ho Kim, Min Ho Cha, Hun Kim
Publikováno v:
Vaccine
Highlights • RNA adjuvant was developed from the CrPV intergenic region IRES. • The RNA adjuvant functioned as an adjuvant with protein-based vaccines. • The RNA adjuvant increased vaccine efficacy and induced balanced Th1/Th2 response. • The
Autor:
George Gardner, Evangelia G. Kranias, Guo-Chang Fan, Guan-Sheng Liu, Jiang Qian, Yutian Li, Nathan Robbins, Kobra Haghighi, Jack Rubinstein, Burns C. Blaxall, Min Jiang, Joshua G. Travers
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • PKA-phosphorylation of Hsp20 is elevated in human failing hearts. • Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function. • The phosphorylated
Highlights • PKA-phosphorylation of Hsp20 is elevated in human failing hearts. • Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function. • The phosphorylated