Zobrazeno 1 - 10
of 381
pro vyhledávání: '"TFR1"'
Autor:
Xingzhi Jing, Wenchao Wang, Xining He, Xiaoyang Liu, Xiaoxia Yang, Cheng Su, Yuandong Shao, Zhongpeng Ge, Heran Wang, Xingang Cui
Publikováno v:
Journal of Orthopaedic Translation, Vol 46, Iss , Pp 65-78 (2024)
Backgroud: Iron overload is a prevalent condition in the elderly, often associated with various degenerative diseases, including intervertebral disc degeneration (IDD). Nevertheless, the mechanisms responsible for iron ion accumulation in tissues and
Externí odkaz:
https://doaj.org/article/8bc8d7a48b99435d89240c87eb049338
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 285, Iss , Pp 117135- (2024)
Background: Hypoxia caused by global climate change and human activities has become a growing concern eliciting serious effect and damages to aquatic animals. Hexagrammos otakii is usually a victim of hypoxia which caused by high density aquaculture
Externí odkaz:
https://doaj.org/article/19790f40aacb4104b24ef2a4b015fe50
Autor:
Wenchao Wang, Zhenkai Ma, Xuemin Feng, Jiabin Ren, Shengyao Sun, Yuandong Shao, Weimin Zhang, Xiaoxia Yang, Jiaming Zhang, Xingzhi Jing
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Objective Transferrin receptor-1 (TfR1) plays important roles in controlling cellular iron levels, but its role in OA pathology is unknown. Herein we aim to investigate the role of TfR1 in OA progression and its underlying mechanisms. Method
Externí odkaz:
https://doaj.org/article/045621c803714311bd2ad29228a3d1f7
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-15 (2024)
Abstract Iron metabolism disorders are implicated in the pathogenesis of Alzheimer’s disease (AD). It was previously reported that transferrin receptor (TFR1) expression was upregulated in AD mouse model. However, the precise biological functions o
Externí odkaz:
https://doaj.org/article/ec2c35f51c3a4c13bdcd9f61ee563303
Autor:
Lidia A. Mielke Cabello, Gabriela Meresman, Dogus Darici, Noelia Carnovale, Birthe Heitkötter, Miriam Schulte, Nancy A. Espinoza-Sánchez, Quang-Khoi Le, Ludwig Kiesel, Sebastian D. Schäfer, Martin Götte
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 876 (2024)
Ferroptosis, an iron-dependent form of non-apoptotic cell death, plays a pivotal role in various diseases and is gaining considerable attention in the realm of endometriosis. Considering the classical pathomechanism theories, we hypothesized that fer
Externí odkaz:
https://doaj.org/article/304106cd3d0c40af8069a27a2180ef60
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Osteosarcoma (OS) is the most common primary solid malignant tumour of bone, with rapid progression and a very poor prognosis. Iron is an essential nutrient that makes it an important player in cellular activities due to its inherent ability
Externí odkaz:
https://doaj.org/article/36c6d865507d4caf8da0ab59c93ef996
Publikováno v:
Redox Report, Vol 27, Iss 1, Pp 119-127 (2022)
Objective The inhibiting effect of Norcantharidin (NCTD) on IL-6 (interleukin-6) and STAT3 and the involvement of the IL-6/STAT3 pathway in hepcidin expression prompted us to speculate that NCTD could affect iron metabolism.Methods We examined the ef
Externí odkaz:
https://doaj.org/article/dd35f74b76e8404c8c8ff78688f6c216
Autor:
Svetlana V. Chulkova, Elena N. Sholokhova, Irina V. Poddubnaya, Ivan S. Stilidi, Nikolai N. Tupitsyn
Publikováno v:
Современная онкология, Vol 24, Iss 3, Pp 355-360 (2022)
Background. Transferrin receptor 1 (TfR1) expression has been identified in a number of malignant tumors. It is noted that its overexpression gives growth advantages to cancer cells. Estimation of transferrin receptor expression in breast cancer (BC)
Externí odkaz:
https://doaj.org/article/e658f7781c864851a2b4b5bfcaadce81
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102779- (2023)
Background: Apolipoprotein E deficiency (ApoE−/−) increases progressively iron in the liver, spleen and aortic tissues with age in mice. However, it is unknown whether ApoE affects brain iron. Methods: We investigated iron contents, expression of
Externí odkaz:
https://doaj.org/article/8dacabb7545b41b18cfe18128c29f433
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