Výsledky vyhledávání - "TFEB, transcription factor EB"

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Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218

Autor: Po Hu, Hongzheng Wang, Xiaoxuan Yu, Wenzhuo Sun, Hui Hui, Hui Li, Mengyuan Zhu, Zhanyu Wang, Jingyan Xu, Qinglong Guo, Yingjie Qing

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3178-3192 (2021)
Acta Pharmaceutica Sinica. B

The integrity of lysosomes is of vital importance to survival of tumor cells. We demonstrated that LW-218, a synthetic flavonoid, induced rapid lysosomal enlargement accompanied with lysosomal membrane permeabilization in hematological malignancy. LW

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2bc1bb062d92dcf545995a174a1320
http://www.sciencedirect.com/science/article/pii/S2211383521000411

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Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease

Autor: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. B

Parkinson's disease (PD), known as one of the most universal neurodegenerative diseases, is a serious threat to the health of the elderly. The current treatment has been demonstrated to relieve symptoms, and the discovery of new small-molecule compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dab43aca56bfd6a912c2aa71297ff
http://www.sciencedirect.com/science/article/pii/S2211383521000642

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Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Autor: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

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Gene therapy for neurodegenerative disorders: advances, insights and prospects

Autor: Dianwen Ju, Yang Hu, Wei Chen

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1347-1359 (2020)

Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Some early clinical trials have failed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b140cd71516f9b1622ac1023338efec
https://doi.org/10.1016/j.apsb.2020.01.015

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Targeting autophagy-related protein kinases for potential therapeutic purpose

Autor: Jifa Zhang, Bo Liu, Liang Ouyang, Honggang Xiang, Congcong Lin, Lan Zhang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 569-581 (2020)
Acta Pharmaceutica Sinica. B

Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays a significant role in the quality control of macromolecules and organelles. Since protein kinases are integral to the autophagy proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e45bf1ac401222740c4f8e78dae670
http://www.sciencedirect.com/science/article/pii/S221138351930276X

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p53 regulates skeletal muscle mitophagy and mitochondrial quality control following denervation-induced muscle disuse

Autor: David Hood, Jonathan Memme, Ashley Oliveira

Publikováno v: The Journal of Biological Chemistry

Persistent inactivity promotes skeletal muscle atrophy, marked by mitochondrial aberrations that affect strength, mobility, and metabolic health leading to the advancement of disease. Mitochondrial quality control (MQC) pathways include biogenesis (s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb3a97e49a86a03392f94c39be1c648
https://pubmed.ncbi.nlm.nih.gov/34958797

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Regulation of mitochondrial cargo-selective autophagy by posttranslational modifications

Autor: Milana Fraiberg, Boris Macek, Zvulun Elazar, Philipp J. Kahle, Anna Lechado Terradas, Katharina Zittlau

Publikováno v: The Journal of Biological Chemistry
The journal of biological chemistry 297(5), 101339 (2021). doi:10.1016/j.jbc.2021.101339

Mitochondria are important organelles in eukaryotes. Turnover and quality control of mitochondria are regulated at the transcriptional and posttranslational level by several cellular mechanisms. Removal of defective mitochondrial proteins is mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbec8d603702bfc18179f4f97b4c81b
http://europepmc.org/articles/PMC8591368

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Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion

Autor: Bin Sun, Huanmin Niu, Hong-Xiang Lou, Fang Wang, Huiqing Yuan, Qian Wang, Xiao-Tian Ji, Effat Un Nesa, Wenjian Liu, Lilin Qian, Yanhai Luo

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 923-936 (2019)

It is critical to regulate the senescence-associated secretory phenotype (SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M (Mar-M, a naturally oc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bcbf93a8ce076cb653df6c09386080
https://doi.org/10.1016/j.apsb.2019.08.007

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Natural compounds modulate the autophagy with potential implication of stroke

Autor: Mengru Liu, Shijia Ma, Yue Li, Anil Ahsan, Wenping Yan, Yanrong Zheng, Zhong Chen, Zhanxun Wu, Ming Cao, Xingxian Zhang, Weiwei Hu, Ling Pan, Xiangnan Zhang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1708-1720 (2021)

Stroke is considered a leading cause of mortality and neurological disability, which puts a huge burden on individuals and the community. To date, effective therapy for stroke has been limited by its complex pathological mechanisms. Autophagy refers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8275a01a7067dd1af9480fcfa0d27454
https://pubmed.ncbi.nlm.nih.gov/34386317

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