Zobrazeno 1 - 10
of 4 065
pro vyhledávání: '"TFEB"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Neuronal death was frequently driven by autophagic/lysosomal dysfunction after ischemic stroke, whereas how to restore the impaired autophagic flux remained elusive. Autophagic/lysosomal signaling could be augmented after transcription facto
Externí odkaz:
https://doaj.org/article/ed1f662750754d7a851db6903e979242
Publikováno v:
Livers, Vol 4, Iss 3, Pp 377-387 (2024)
Acetaminophen (APAP) overdose can induce hepatocyte necrosis and acute liver failure in experimental rodents and humans. APAP is mainly metabolized via hepatic cytochrome P450 enzymes to generate the highly reactive metabolite N-acetyl-p-benzoquinone
Externí odkaz:
https://doaj.org/article/64659b169e2942ee823e5360833d3c20
Autor:
Muhlis Akman, Ciro Monteleone, Gabriella Doronzo, Martina Godel, Francesca Napoli, Alessandra Merlini, Virginia Campani, Valeria Nele, Elisa Balmas, Tatiana Chontorotzea, Simona Fontana, Sabrina Digiovanni, Francesca Alice Barbu, Elena Astanina, Niloufar Jafari, Iris Chiara Salaroglio, Joanna Kopecka, Giuseppe De Rosa, Thomas Mohr, Alessandro Bertero, Luisella Righi, Silvia Novello, Giorgio Vittorio Scagliotti, Federico Bussolino, Chiara Riganti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)
Abstract Background In non-small cell lung cancer (NSCLC) the efficacy of chemo-immunotherapy is affected by the high expression of drug efflux transporters as ABCC1 and by the low expression of ABCA1, mediating the isopentenyl pyrophosphate (IPP)-de
Externí odkaz:
https://doaj.org/article/4a6851a8a8824044acb7cc89ddb408bf
Autor:
Li-Ping Zhao, Hao-Jie Wang, Die Hu, Jun-Hu Hu, Zheng-Rong Guan, Li-Hua Yu, Ya-Ping Jiang, Xiao-Qi Tang, Zhao-Huang Zhou, Tian Xie, Jian-Shu Lou
Publikováno v:
Journal of Advanced Research, Vol 62, Iss , Pp 257-272 (2024)
Introduction: β-Elemene (β-ELE), derived from Curcuma wenyujin, has anticancer effect on non-small cell lung cancer (NSCLC). However, the potential target and detail mechanism were still not clear. TFEB is the master regulator of lysosome biogenesi
Externí odkaz:
https://doaj.org/article/6f41ae41c6de4938ab8e6923be52beb5
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background Paclitaxel (PTX) treatment resistance is an important factor leading to poor prognosis in triple-negative breast cancer (TNBC), therefore there is an urgent need to identify new target for combination therapy. Neddylation is a pos
Externí odkaz:
https://doaj.org/article/1a422ba9c77b4f8f88c70135cf74760a
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Beta-amyloid (Aβ) deposition in the brain parenchyma is a crucial initiating step in the amyloid cascade hypothesis of Alzheimer’s disease (AD) pathology. Furthermore, dysfunction of plaque-associated microglia, also known as d
Externí odkaz:
https://doaj.org/article/2a70f5339f094dd3910c6f429a3197af
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39752- (2024)
The major cause of death in cancer patients is a combination of metastatic dissemination combined with therapy resistance. Over recent years, intratumour phenotypic heterogeneity arising from the bi-directional interplay between plastic cancer cells
Externí odkaz:
https://doaj.org/article/de53395a47e144b0be27165c63f488ef
Publikováno v:
PeerJ, Vol 12, p e18209 (2024)
Cardiovascular disease (CVD) remains the major cause of morbidity and mortality around the world. Transcription factor EB (TFEB) is a master regulator of lysosome biogenesis and autophagy. Emerging studies revealed that TFEB also mediates cellular ad
Externí odkaz:
https://doaj.org/article/3a94ec9645e445e4972ce166daf969d2
Autor:
Jieru Lin, Chunhuan Huang, Jingye Zhao, Lu Li, Zhenwei Wu, Tingyu Zhang, Yuyin Li, Wei Li, Baoqiang Guo, Zhenxing Liu, Aipo Diao
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The autophagy-lysosome pathway plays an essential role in promoting lipid catabolism and preventing hepatic steatosis in non-alcoholic fatty liver disease (NAFLD). Transcription factor EB (TFEB) enhances the autophagy-lysosome pathway by regulating t
Externí odkaz:
https://doaj.org/article/5960ee12d82146df92e65508939b3737
Autor:
Jiazhen Wu, Fengkun Guan, Haipiao Huang, Hanbin Chen, Yuhong Liu, Shangbin Zhang, Muxia Li, Jianping Chen
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117297- (2024)
Purpose: To investigate the therapeutic effect and underlying mechanism of tetrahydrocurcumin (THC) on nonalcoholic steatohepatitis (NASH) induced by high-fat diet (HFD). Methods: NASH rat model was established through long-term feeding HFD, and the
Externí odkaz:
https://doaj.org/article/944d8a9f5bce4fc2b18e1329a66ae3c7