Zobrazeno 1 - 10
of 130
pro vyhledávání: '"TFA, trifluoroacetic acid"'
Autor:
Xin Li, Robert S. Hodges, Kenza Mamouni, Hong Yan Liu, Lajos Gera, Rui Zhao, Alira Danaher, Lijuan Bai, Nicholas Cook, Xiaowei Ma, Omer Kucuk, Yang Yang, Daqing Wu
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1261-1274 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1261-1274 (2021)
A major challenge to the treatment of advanced prostate cancer (PCa) is the development of resistance to androgen-deprivation therapy (ADT) and chemotherapy. It is imperative to discover effective therapies to overcome drug resistance and improve cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a832ce1861512439071b5f1c6c32f2
https://doi.org/10.1016/j.neo.2021.11.006
https://doi.org/10.1016/j.neo.2021.11.006
Autor:
Tiantian Qi, Letian Zhang, Tingyuan Yang, Yating Luo, Shiliang Li, Fanxun Zeng, Lili Zhu, Guantian Yang, Yingfan Liang, Honglin Li, Rui Wang, Xiaoyong Xu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 795-809 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). Herein, a series of acrylamide-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe3ff9d9c75c7a612636b452a341e1f
http://www.sciencedirect.com/science/article/pii/S2211383520307590
http://www.sciencedirect.com/science/article/pii/S2211383520307590
Autor:
Sten Ohlson, Minh-Dao Duong-Thi, Anandalakshmi Venkatraman, Konstantin Pervushin, Jodhbir S. Mehta
Publikováno v:
Journal of Advanced Research, Vol 24, Iss, Pp 529-543 (2020)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Highlights • Corneal stromal dystrophies are a group of hereditary disorders caused by mutations in the TGFBI gene and affect the corneal stroma and epithelium. • The disease is characterized by the accumulation of insolub
Highlights • Corneal stromal dystrophies are a group of hereditary disorders caused by mutations in the TGFBI gene and affect the corneal stroma and epithelium. • The disease is characterized by the accumulation of insolub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ba3b1d04347c4a9bdcc95cfce96a0b
http://www.sciencedirect.com/science/article/pii/S2090123220300953
http://www.sciencedirect.com/science/article/pii/S2090123220300953
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297, pp.101252. ⟨10.1016/j.jbc.2021.101252⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, 2021, 297, pp.101252. ⟨10.1016/j.jbc.2021.101252⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297, pp.101252. ⟨10.1016/j.jbc.2021.101252⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, 2021, 297, pp.101252. ⟨10.1016/j.jbc.2021.101252⟩
International audience; The rigid core of intracellular tau filaments from Alzheimer’s disease (AD), Pick’s disease (PiD), and Corticobasal disease (CBD) brains has been shown to differ in their cryo-EM atomic structure. Despite providing critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb73365cfdfb93b7855667803503848
https://hal-cea.archives-ouvertes.fr/cea-03384553
https://hal-cea.archives-ouvertes.fr/cea-03384553
Publikováno v:
The Journal of Biological Chemistry
The orphan nuclear receptor Nur77 is an immediate-early response gene that based on tissue and cell context is implicated in a plethora of cellular processes, including proliferation, differentiation, apoptosis, metabolism, and inflammation. Nur77 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c99aa4be44c900232e7687a01220fd4
https://pubmed.ncbi.nlm.nih.gov/34571009
https://pubmed.ncbi.nlm.nih.gov/34571009
Autor:
Monika Dzieciatkowska, Lauren R. Schmitt, Toin H. van Kuppevelt, Willeke F. Daamen, Mark Maslanka, Ryan C. Hill, Maxwell C. McCabe, Kirk C. Hansen, Danique J. Hof
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics, 20
Molecular & Cellular Proteomics, 20
The extracellular matrix is a key component of tissues, yet it is underrepresented in proteomic datasets. Identification and evaluation of proteins in the extracellular matrix (ECM) has proved challenging due to the insolubility of many ECM proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2083f5875a9c4968507a0ff8208d5d
http://europepmc.org/articles/PMC8188056
http://europepmc.org/articles/PMC8188056
Autor:
Jing Yang, Ramesh Neelamegam, Jinchun Song, Gengyang Yuan, Ping Bai, Chongzhao Ran, Marc D. Normandin, Changning Wang, Michael S. Placzek, Zude Chen, Hayden R. Schmidt, Stephanie A. Fiedler, Hao Wang, Yu Lan, Xiying Qu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1204-1215 (2019)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays a major role in various pathological conditions in the central nervous system (CNS), implicated in several neuropsychiatric disorders. Imaging of σ1R in the brain using positr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a5701aa32f8f8afaa0cf073ac28afc
https://doi.org/10.1016/j.apsb.2019.07.002
https://doi.org/10.1016/j.apsb.2019.07.002
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 279-293 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 279-293 (2019)
Over recent decades, many studies have reported that hypocrellin A (HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticancer effect has not been fully defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234a255e7495bc3248845012723dbc6e
https://doi.org/10.1016/j.apsb.2018.12.004
https://doi.org/10.1016/j.apsb.2018.12.004
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 144-156 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 144-156 (2019)
Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5741217633748b64d45c5b084c61c9e6
https://doi.org/10.1016/j.apsb.2018.08.003
https://doi.org/10.1016/j.apsb.2018.08.003
Autor:
Aleksandra Shcherbakova, Karsten Cirksena, Joachim Wittbrodt, Falk F. R. Buettner, Roman Sakson, Lars R. Jensen, Thomas Ruppert, Daniel Todt, Andreas W. Kuss, Alina Friedrich, Stefan Weiss, Hermann J. Hütte, Hans Bakker, Thomas Thumberger
Publikováno v:
Molecular & Cellular Proteomics : MCP
C-mannosylation is a modification of tryptophan residues with a single mannose and can affect protein folding, secretion, and/or function. To date, only a few proteins have been demonstrated to be C-mannosylated, and studies that globally assess prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dcfa5ab5c34fd0ed0c4709b4ea4419
https://pubmed.ncbi.nlm.nih.gov/33975020
https://pubmed.ncbi.nlm.nih.gov/33975020