Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Autor: Yi Lu, Zhongjian Chen, Wei Wu, Pijush Kumar Paul, Quangang Zhu, Jianping Qi

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)

Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6732d4326595a5ad29955ebaff92173
https://doi.org/10.1016/j.apsb.2021.04.001

Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolysaccharidosis type II

Autor: Tohru Hirato, Kohtaro Minami, Masafumi Kinoshita, Eiji Yoden, Atsushi Imakiire, Ryuji Yamamoto, Noboru Tanaka

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 27, Iss, Pp 100758-(2021)
Molecular Genetics and Metabolism Reports

Pabinafusp alfa is a fusion protein comprising a humanized anti-human transferrin receptor (TfR) antibody and human iduronate-2-sulfatase. It was developed as a novel modality to target central nervous system-related symptoms observed in patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0bad9d33274408b77250340e21baeff
http://www.sciencedirect.com/science/article/pii/S2214426921000525

Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14

Autor: Toshiyuki Fukada, Shintaro Hojyo, Thomas B. Bartnikas, Bogdan Budnik, Heather L. Conboy, Milankumar Prajapati

Publikováno v: The Journal of Biological Chemistry

Iron is essential for erythropoiesis and other biological processes, but is toxic in excess. Dietary absorption of iron is a highly regulated process and is a major determinant of body iron levels. Iron excretion, however, is considered a passive, un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60b5d4386577fe170af0e0fd9843dcc
http://europepmc.org/articles/PMC8214222

Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance

Autor: Yan Wang, Yalin Wu, Zuguo Liu, Jingmeng Chen, Chao Chen

Publikováno v: The Journal of Biological Chemistry

The death of photoreceptor cells in dry age-related macular degeneration (AMD) and autosomal recessive Stargardt disease (STGD1) is closely associated with disruption in all-trans-retinal (atRAL) clearance in neural retina. In this study, we reveal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e528672cccb4554ebf9c4e807e79212a
https://pubmed.ncbi.nlm.nih.gov/33334878

Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium

Autor: Simona Simmen, Jesus Cosin-Roger, Cheryl de Valliere, Katharina Spanaus, Katharina Baebler, Chiaki Maeyashiki, Nikolaos Maliachovas, Jonas Zeitz, Gerhard Rogler, Pedro A. Ruiz, Hassan Melhem, Stephan R. Vavricka, Bruce Weder, Max Maane, Martin Hausmann, Michael Scharl

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 339-355 (2019)

Background & Aims: Hypoxia-associated pathways influence the development of inflammatory bowel disease. Adaptive responses to hypoxia are mediated through hypoxia-inducible factors, which are regulated by iron-dependent hydroxylases. Signals reflecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b468eae5dd78052ab560274d719c8cf0
http://europepmc.org/articles/PMC6357696