Zobrazeno 1 - 10
of 276
pro vyhledávání: '"TET enzymes"'
Autor:
Sara Vasconcelos, Carla Caniçais, Susana M. Chuva de Sousa Lopes, C. Joana Marques, Sofia Dória
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-11 (2023)
Abstract The placenta is a temporary organ that is essential for supporting mammalian embryo and fetal development. Understanding the molecular mechanisms underlying trophoblast differentiation and placental function may contribute to improving the d
Externí odkaz:
https://doaj.org/article/1a50f62be6fd4e2e80c790784fd54832
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
A dysregulated immune microenvironment at the maternal-fetal interface in early pregnancy may lead to early pregnancy loss, fetal growth restriction, and preeclampsia. However, major questions about how epigenetic modifications regulate the immune mi
Externí odkaz:
https://doaj.org/article/da8bda89ae8744cf9c3c3c583ba90a8e
Autor:
Anna Wołowiec, Łukasz Wołowiec, Grzegorz Grześk, Albert Jaśniak, Joanna Osiak, Jakub Husejko, Mariusz Kozakiewicz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13723 (2023)
Epigenetics is a rapidly developing science that has gained a lot of interest in recent years due to the correlation between characteristic epigenetic marks and cardiovascular diseases (CVDs). Epigenetic modifications contribute to a change in gene e
Externí odkaz:
https://doaj.org/article/9443c14e867b48188f39406d02137dc1
Autor:
Antoine Abou-Jaoude, Cheng-Yen Huang, Julio C. Flores, Mirunalini Ravichandran, Run Lei, Stephanie Chrysanthou, Meelad M. Dawlaty
Publikováno v:
Stem Cell Research, Vol 61, Iss , Pp 102770- (2022)
The Inhibitor of disheveled and axin (Idax) and its ortholog the Retinoid inducible nuclear factor (Rinf) are DNA binding proteins with nuclear and cytoplasmic functions. Rinf is expressed in embryonic stem cells (ESCs) where it regulates transcripti
Externí odkaz:
https://doaj.org/article/efce396a6d9347f78f4be7f1990be4ed
Autor:
João C Sabino, Madalena R de Almeida, Patrícia L Abreu, Ana M Ferreira, Paulo Caldas, Marco M Domingues, Nuno C Santos, Claus M Azzalin, Ana Rita Grosso, Sérgio Fernandes de Almeida
Publikováno v:
eLife, Vol 11 (2022)
DNA oxidation by ten-eleven translocation (TET) family enzymes is essential for epigenetic reprogramming. The conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) initiates developmental and cell-type-specific transcriptional prog
Externí odkaz:
https://doaj.org/article/69620d7f7791425baa6c07e269b1c53d
Publikováno v:
Epigenetics, Vol 14, Iss 12, Pp 1234-1244 (2019)
Epigenetic mechanisms such as genomic imprinting have a fundamental role in embryo and fetal development. Hence, we here studied expression levels of epigenetic modifiers and imprinted genes in cases of ididopathic spontaneous abortion (SA). Thirty-f
Externí odkaz:
https://doaj.org/article/2f7ea5bb992f405db99e4b0b36816f0c
Akademický článek
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Autor:
Ian C. MacArthur, Meelad M. Dawlaty
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Studies of tissue-specific epigenomes have revealed 5-hydroxymethylcytosine (5hmC) to be a highly enriched and dynamic DNA modification in the metazoan nervous system, inspiring interest in the function of this epigenetic mark in neurodevelopment and
Externí odkaz:
https://doaj.org/article/eb1a1ebe00594b3caaabac77bdf8b794
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108452- (2020)
Summary: Plasma cells provide high-affinity antibodies against invading pathogens. Although transcriptional and epigenetic mechanisms have been extensively studied for plasma cell differentiation, how these mechanisms respond to environmental cues re
Externí odkaz:
https://doaj.org/article/1c28aee5f6bf4a0ca7019343e5a38502
Autor:
Zuodong Zhao, Zhuqiang Zhang, Jingjing Li, Qiang Dong, Jun Xiong, Yingfeng Li, Mengying Lan, Gang Li, Bing Zhu
Publikováno v:
eLife, Vol 9 (2020)
Transcriptional memory allows certain genes to respond to previously experienced signals more robustly. However, whether and how the key proinflammatory cytokine TNF-α mediates transcriptional memory are poorly understood. Using HEK293F cells as a m
Externí odkaz:
https://doaj.org/article/c92a2bb34c3e4027b1ba99dd7075cb02