Zobrazeno 1 - 10
of 3 199
pro vyhledávání: '"TERT promoter"'
Autor:
Gongxun Tan, Bingquan Jin, Xiaoqin Qian, Yuguo Wang, Guoliang Zhang, Enock Adjei Agyekum, Feng Wang, Liang Shi, Yue Zhang, Zhenwei Mao, Chunhe Shi, Ying Xu, Xiuying Li, Lele Zhang, Shaohua Li
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Telomerase reverse transcriptase promoter (TERTp) mutations are associated with non-radioiodine avidity. However, the role of these mutations in the clinical outcomes of patients with radioiodine-refractory differentiated thyroid cancer (RAI
Externí odkaz:
https://doaj.org/article/0d87f4f3035046e9931051e01beef8b0
Publikováno v:
Endocrine Connections, Vol 13, Iss 11, Pp 1-12 (2024)
Next-generation sequencing (NGS) is of great benefit to clinical practice in terms of identifying genetic alterations. This study aims to clarify the gene background and its influence on thyroid tumors in the Chinese population. NGS data and correspo
Externí odkaz:
https://doaj.org/article/96a23f1dbbea4f0a9dd4b5b73fd4aadf
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-6 (2024)
Abstract Background Spitz tumors are relatively uncommon melanocytic lesions, typically affecting a relatively younger population but can be encountered at any age. They are characterized by a proliferation of melanocytes with epithelioid and/or spin
Externí odkaz:
https://doaj.org/article/52deca62e0d44a2da92a01992b14a73f
Autor:
Sonia Pérez González, Victoria Heredia-Soto, Manuel Girón de Francisco, Elia Pérez-Fernández, Rubén Casans-Francés, Marta Mendiola Sabio, Pilar González-Peramato
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 2845-2855 (2024)
The TERT (Telomerase Reverse Transcriptase) gene promoter mutation is one of the most prevalent mutations in urothelial bladder tumors and this mutation is related to bladder tumor progression. Our purpose was to evaluate the presence of this mutatio
Externí odkaz:
https://doaj.org/article/c9c0f2b745274a828821c6898db31005
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
ObjectiveTelomerase reverse transcriptase (TERT) promoter mutation status in gliomas is a key determinant of treatment strategy and prognosis. This study aimed to analyze the radiogenomic features and construct radiogenomic models utilizing medical i
Externí odkaz:
https://doaj.org/article/bd6655ff82f9411baff1ce92a487f788
Autor:
David Sinan Koca, Vladimir Kolpakov, Jana Ihlow, Maximilian von Laffert, Katharina Erb-Eigner, Hermann Herbst, Karen Kriese, Leonille Schweizer, Eckart Bertelmann
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 2, Pp 1467-1484 (2024)
The orbital manifestation of a solitary fibrous tumor (SFT) is exceptionally rare and poses specific challenges in diagnosis and treatment. Its rather exceptional behavior among all SFTs comprises a high tendency towards local recurrence, but it rare
Externí odkaz:
https://doaj.org/article/fe0b74bf76f24a629106545b51006671
Autor:
Qin Tang, Guanghui Hu, Ye Sang, Yulu Chen, Guangyan Wei, Meiyan Zhu, Mengke Chen, Shiyong Li, Rengyun Liu, Zhenwei Peng
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Background Hotspot mutations in the promoter of telomerase reverse transcriptase (TERT) gene are the most common genetic variants in hepatocellular carcinoma (HCC) and associated with poor prognosis of the disease. However, no drug was curre
Externí odkaz:
https://doaj.org/article/70872f9b1ffa48a7bbc1407a22f3f09e
Autor:
Aleksey Drobyshev, Alexander Modestov, Maria Suntsova, Elena Poddubskaya, Alexander Seryakov, Aleksey Moisseev, Maksim Sorokin, Victor Tkachev, Galina Zakharova, Aleksander Simonov, Marianna A. Zolotovskaia, Anton Buzdin
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
The TERT gene encodes the reverse transcriptase subunit of telomerase and is normally transcriptionally suppressed in differentiated human cells but reactivated in cancers where its expression is frequently associated with poor survival prognosis. He
Externí odkaz:
https://doaj.org/article/3dc19069f31e4c6d85a36102e9c4f88d
Autor:
Haiyan Gu, Jingnan Wang, Wenwen Ran, Guangqi Li, Shasha Hu, Han Zhao, Xiaonan Wang, Jigang Wang
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract Anaplastic thyroid carcinoma (ATC) is the most advanced and aggressive thyroid cancer, and poorly differentiated thyroid carcinoma (PDTC) lacks anaplastic histology but has lost architectural and cytologic differentiation. Only a few studies
Externí odkaz:
https://doaj.org/article/4850bb6b85f446b296371c523a705f93
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