Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound

Autor: Bruno Pagano, Erica Salvati, Simona Marzano, Stefano De Tito, Eleonora Vertecchi, Jussara Amato, Anna Di Porzio, Nunzia Iaccarino, Antonio Randazzo

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10315, p 10315 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

DNA G-quadruplex (G4) structures, either within gene promoter sequences or at telomeres, have been extensively investigated as potential small-molecule therapeutic targets. However, although G4s forming at the telomeric DNA have been extensively inve

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https://www.mdpi.com/1422-0067/22/19/10315