Establishment of a reproducible and minimally invasive ischemic stroke model in swine

Autor: Carlos Castaño, Marc Melià-Sorolla, Alexia García-Serran, Núria DeGregorio-Rocasolano, Maria Rosa García-Sort, María Hernandez-Pérez, Adrián Valls-Carbó, Osvaldo Pino, Jordi Grífols, Alba Iruela-Sánchez, Alicia Palomar-García, Josep Puig, Octavi Martí-Sistac, Antoni Dávalos, Teresa Gasull

Publikováno v: JCI Insight, Vol 8, Iss 8 (2023)

The need for advances in the management/treatment options for ischemic stroke patients requires that upcoming preclinical research uses animals with more human-like brain characteristics. The porcine brain is considered appropriate, although the pres

Externí odkaz: https://doaj.org/article/c21de8f593ff4c549dea247127c76ba2

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Autor: Nuria DeGregorio-Rocasolano, Octavi Martí-Sistac, Jovita Ponce, María Castelló-Ruiz, Mònica Millán, Verónica Guirao, Isaac García-Yébenes, Juan B. Salom, Pedro Ramos-Cabrer, Enrique Alborch, Ignacio Lizasoain, José Castillo, Antoni Dávalos, Teresa Gasull

Publikováno v: Redox Biology, Vol 15, Iss C, Pp 143-158 (2018)

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (T

Externí odkaz: https://doaj.org/article/facd8b78a4874d8e865b236e82696fcb

Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis

Autor: Núria DeGregorio-Rocasolano, Octavi Martí-Sistac, Teresa Gasull

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

In general, iron represents a double-edged sword in metabolism in most tissues, especially in the brain. Although the high metabolic demands of brain cells require iron as a redox-active metal for ATP-producing enzymes, the brain is highly vulnerable

Externí odkaz: https://doaj.org/article/bdab2dc43de64d5780db4fcecd586f2a

Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia

Autor: Júlia Faura, Laura Ramiro, Alba Simats, Feifei Ma, Anna Penalba, Teresa Gasull, Anna Rosell, Joan Montaner, Alejandro Bustamante

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8093
International Journal of Molecular Sciences
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

After stroke and other brain injuries, there is a high incidence of respiratory complications such as pneumonia or acute lung injury. The molecular mechanisms that drive the brain-lung interaction post-stroke have not yet been elucidated. We performe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd127755b1173beda6d110e2862cc70a
https://hdl.handle.net/10668/21178

Targeting pro-oxidant iron with deferoxamine as a treatment for ischemic stroke: safety and optimal dose selection in a randomized clinical trial

Autor: José Vivancos, Pilar Giner, Octavi Martí-Sistac, Francisco Campos, Florentino Nombela, Jordi Cortés, Tomás Sobrino, Natalia Pérez de la Ossa, Silvia Reverté, Manuel Rodríguez-Yáñez, Mónica Millán, Teresa Gasull, Nuria DeGregorio-Rocasolano, Joaquín Serena, Joan Costa, Yolanda Silva, Antoni Dávalos

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Antioxidants, Vol 10, Iss 1270, p 1270 (2021)
Antioxidants; Volume 10; Issue 8; Pages: 1270
Antioxidants

A role of iron as a target to prevent stroke-induced neurodegeneration has been recently revisited due to new evidence showing that ferroptosis inhibitors are protective in experimental ischemic stroke and might be therapeutic in other neurodegenerat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe9728eec1d62789248fbc52096cba8