Guardians of the Genome: How the Single-Stranded DNA-Binding Proteins RPA and CST Facilitate Telomere Replication

Autor: Conner L. Olson, Deborah S. Wuttke

Publikováno v: Biomolecules, Vol 14, Iss 3, p 263 (2024)

Telomeres act as the protective caps of eukaryotic linear chromosomes; thus, proper telomere maintenance is crucial for genome stability. Successful telomere replication is a cornerstone of telomere length regulation, but this process can be fraught

Externí odkaz: https://doaj.org/article/96edfbc23449414185031698b2f5de15

POT1-TPP1 telomere length regulation and disease

Autor: Emmanuel Skordalakes, Tomas M. Aramburu, Sarah Plucinsky

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1939-1946 (2020)

Telomeres are DNA repeats at the ends of linear chromosomes and are replicated by telomerase, a ribonucleoprotein reverse transcriptase. Telomere length regulation and chromosome end capping are essential for genome stability and are mediated primari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dd908869527a7f37cd216b7f0f8687
http://europepmc.org/articles/PMC7385035

Clarifying the Role of the CST Complex in DNA Replication and Repair

Autor: Wysong, Brandon Carter

Indiana University-Purdue University Indianapolis (IUPUI)
Ends of linear chromosomes are maintained by specialized structures known as telomeres. These structures are protected by a number of essential protein complexes including the shelterin c

Externí odkaz: https://hdl.handle.net/1805/27372

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The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells

Autor: Stefano Annunziato, Jinhyuk Bhin, Marieke van de Ven, Rachel Brough, Bastiaan Evers, Marco Barazas, Catrin Lutz, Stephen J. Pettitt, Dik C. van Gent, Jacqueline J.L. Jacobs, Stefan J. Roobol, Jessica Frankum, Jos Jonkers, Inge de Krijger, Hind Ghezraoui, Fei Fei Song, Christopher J. Lord, J. Ross Chapman, Ewa Gogola, Sven Rottenberg

Publikováno v: Barazas, Marco; Annunziato, Stefano; Pettitt, Stephen J; de Krijger, Inge; Ghezraoui, Hind; Roobol, Stefan J; Lutz, Catrin; Frankum, Jessica; Song, Fei Fei; Brough, Rachel; Evers, Bastiaan; Gogola, Ewa; Bhin, Jinhyuk; van de Ven, Marieke; van Gent, Dik C; Jacobs, Jacqueline J L; Chapman, Ross; Lord, Christopher J; Jonkers, Jos and Rottenberg, Sven (2018). The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells. Cell reports, 23(7), pp. 2107-2118. Cell Press 10.1016/j.celrep.2018.04.046
Cell Reports
Cell Reports, 23(7), 2107-2118. Cell Press

Summary Selective elimination of BRCA1-deficient cells by inhibitors of poly(ADP-ribose) polymerase (PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This interaction is counteracted by the restoration of BRCA1-indepe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9e45d97761e8fba307be9acea689a3
http://ora.ox.ac.uk/objects/uuid: