Relationship between expression levels of TDRD7 and CRYBB3 and development of age-related cortico-nuclear cataracts

Autor: Saliha Handan Yildiz, Cem Karaosmanoğlu, Rahmi Duman, Nuray Varol, Müjgan Özdemir Erdoğan, Mustafa Solak, Reşat Duman, Muhsin Elmas

Publikováno v: Egyptian Journal of Medical Human Genetics, Vol 24, Iss 1, Pp 1-8 (2023)

Abstract Background The human lens develops age-related cataracts (ARCs) because of the complicated effects of aging and stressful conditions. Under conditions involving oxidative stress, cells form stress granules (SGs). TDRD7 has been identified as

Externí odkaz: https://doaj.org/article/987f359874d3420da439e51832492c37

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Identification of Tudor domain containing 7 protein as a novel partner and a substrate for ribosomal protein S6 kinaseS – S6K1 and S6K2

Autor: O. Skorokhod, G. Panasyuk, I. Nemazanyy, I. Gout, V. Filonenko

Publikováno v: The Ukrainian Biochemical Journal, Vol 85, Iss 6, Pp 46-52 (2013)

Ribosomal protein S6 kinases (S6Ks) are principal regulators of cell size, growth and metabolism. Signaling via the PI3K/mTOR pathway mediates the activation of S6Ks in response to various mitogenic stimuli, nutrients and stresses. To date, the regul

Externí odkaz: https://doaj.org/article/7c4a7cca76c94462b4c7cd63df5a1b63

Application of wes towards molecular investigation of congenital cataracts: Identification of novel alleles and genes in a hospital-based cohort of South India

Autor: Wolfgang Berger, Sathiyaveedu Thyagarajan Santhiya, Makarla Venkata Sathya Prakash, István Magyar, Jochen Graw, Dinesh Kumar Kandaswamy, Amit Tiwari, Samuel Koller

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9569, p 9569 (2020)
Volume 21
Issue 24
International Journal of Molecular Sciences, 21 (24)
Int. J. Mol. Sci. 21:9569 (2020)

Congenital cataracts are the prime cause for irreversible blindness in children. The global incidence of congenital cataract is 2.2–13.6 per 10,000 births, with the highest prevalence in Asia. Nearly half of the congenital cataracts are of familial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14ba3ee03422aef48d1c691c5e5bb9b

TDRD7, a Novel Viral Restriction Factor, Inhibits Cellular AMP-dependent Kinase to Inhibit Virus Replication

Autor: Subramanian, Gayatri

The interferon (IFN) system is the first line of defense against viral infections. The recognition of viral infection by pattern recognition receptors (PRRs) results in the transcriptional induction of IFN. IFN, secreted from the virus-infected cells

Externí odkaz: http://rave.ohiolink.edu/etdc/view?acc_num=mco1596574176173965