Zobrazeno 1 - 10 of 34 pro vyhledávání: '"TCR-transgenic T cells"'
1
Akademický článek
TCR-transgenic T cells and YB-1-based oncolytic virotherapy improve survival in a preclinical Ewing sarcoma xenograft mouse model
Autor: Sebastian J. Schober, Melanie Thiede, Hendrik Gassmann, Anna Josefine von Ofen, Pia Knoch, Jennifer Eck, Carolin Prexler, Corazon Kordass-Wally, Julia Hauer, Stefan Burdach, Per Sonne Holm, Uwe Thiel
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
BackgroundEwing sarcoma (EwS) is an aggressive and highly metastatic bone and soft tissue tumor in pediatric patients and young adults. Cure rates are low when patients present with metastatic or relapsed disease. Therefore, innovative therapy approa
Externí odkaz: https://doaj.org/article/a52e819a36954a5cb6c30fb713880fa2
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2
Akademický článek
Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and MHC Class 1 Expression on Ewing’s Sarcoma, Enhancing T Cell Cytotoxicity
Autor: Emilie Biele, Sebastian J. Schober, Carolin Prexler, Melanie Thiede, Kristina von Heyking, Hendrik Gassmann, Jennifer Eck, Busheng Xue, Stefan Burdach, Uwe Thiel
Publikováno v: Cells, Vol 10, Iss 11, p 3070 (2021)
Ewing’s sarcoma (EwS) is a pediatric solid tumor entity with low somatic mutational burden and a low rate of tumor-infiltrating T cells, indicating a low extent of immunogenicity. In EwS, immunogenicity may furthermore be significantly diminished b
Externí odkaz: https://doaj.org/article/a017ee78320743c3be409bf39ee9343b
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3
Akademický článek
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4
Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and MHC Class 1 Expression on Ewing’s Sarcoma, Enhancing T Cell Cytotoxicity
Autor: Uwe Thiel, Emilie Biele, Kristina von Heyking, Melanie Thiede, Stefan Burdach, Carolin Prexler, Sebastian J. Schober, Jennifer Eck, Busheng Xue, Hendrik Gassmann
Publikováno v: Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 3070, p 3070 (2021)
Ewing’s sarcoma (EwS) is a pediatric solid tumor entity with low somatic mutational burden and a low rate of tumor-infiltrating T cells, indicating a low extent of immunogenicity. In EwS, immunogenicity may furthermore be significantly diminished b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2691f3887fe38a2799057d89a16bdca
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5
Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy
Autor: Antje Malo, Luka Cicin-Sain, Michael Neuenhahn, Sebastian Jarosch, Dirk H. Busch, Ulrike Protzer, Kilian Schober, Justin Leube, Simon Grassmann, Kathrin Schumann, Manuel Effenberger, T. Müller, Monika Hammel, M. Zeeshan Chaudhry, Bettina Bernard, Immanuel Andrä, Peter Steinberger, Tobias Feuchtinger, Theresa Käuferle
Publikováno v: Cell Reports Medicine
Cell reports. Medicine
United States
Summary Adoptive transfer of T cells expressing a transgenic T cell receptor (TCR) has the potential to revolutionize immunotherapy of infectious diseases and cancer. However, the generation of defined TCR-transgenic T cell medicinal products with pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d483a4b09c3cdd810481c55bb68b7940
http://europepmc.org/articles/PMC8385324
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6
Akademický článek
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7
Akademický článek
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8
In-depth Characterization of a TCR-specific Tracer for Sensitive Detection of Tumor-directed Transgenic T Cells by Immuno-PET
Autor: Stephan G. Nekolla, Sybille Reder, Markus Schwaiger, Calogero D'Alessandria, Henrique de Oliveira Bianchi, Mona Mustafa, Angela M. Krackhardt, Stefan Audehm, Sabine Mall, Nahid Yusufi, Katja Steiger, Richard Klar, Christian Peschel
Publikováno v: Theranostics
A number of different technologies have been developed to monitor in vivo the distribution of gene-modified T cells used in immunotherapy. Nevertheless, in-depth characterization of novel approaches with respect to sensitivity and clinical applicabil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d945d270992c01b0d72387a45bc7de
https://doi.org/10.7150/thno.17994
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9
HLA class I- and class II-restricted T cell receptors for immunotherapy of human cytomegalovirus disease
Autor: Joos, Clemens
Human cytomegalovirus (HCMV) frequently reactivates after hematopoietic stem cell transplantation (HSCT). Antiviral medication is not universally effective and has side effects that prohibit prophylaxis and limit pre-emptive use. Adoptive transfer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46ede121635176b5f91870c37f7c10b3
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10
Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies-the German Cancer Consortium approach
Autor: Krackhardt, A. M., Anliker, B., Hildebrandt, M., Bachmann, M., Eichmüller, S. B., Nettelbeck, D. M., Renner, M., Uharek, L., Willimsky, G., Schmitt, M., Wels, W. S., Schüssler-Lenz, M.
Publikováno v: Cancer Immunology, Immunotherapy 67(2018)4, 513-523
Adoptive transfer of T cells genetically modified by TCRs or CARs represents a highly attractive novel therapeutic strategy to treat malignant diseases. Various approaches for the development of such gene therapy medicinal products (GTMPs) have been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::172102833fea2a30247b1f7e94b5c36d
https://www.hzdr.de/publications/Publ-27138-1
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