Zobrazeno 1 - 10
of 50
pro vyhledávání: '"TCR triggering"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cell receptors (TCRs) play crucial roles in regulating T cell response by rapidly and accurately recognizing foreign and non-self antigens. The process involves multiple molecules and regulatory mechanisms, forming a complex network to achieve effe
Externí odkaz:
https://doaj.org/article/e8b96d605f664a2ca35e015a68ce6144
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic development, but how they contribute to immune responses in the periphery is unclear. Coreceptors strengthen T-cell responses by many orders of magnitude – bey
Externí odkaz:
https://doaj.org/article/718d990dbd3f4b5ab090986fc4573a64
Autor:
Pageon, Sophie V., Tabarin, Thibault, Yamamoto, Yui, Ma, Yuanqing, Nicovich, Philip R., Bridgeman, John S., Cohnen, André, Benzing, Carola, Gao, Yijun, Crowther, Michael D., Tungatt, Katie, Dolton, Garry, Sewell, Andrew K., Price, David A., Acuto, Oreste, Parton, Robert G., Gooding, J. Justin, Rossy, Jérémie, Rossjohn, Jamie, Gaus, Katharina
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2016 Sep . 113(37), E5454-E5463.
Externí odkaz:
https://www.jstor.org/stable/26471808
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
How T cell receptors (TCRs) are triggered to start signaling is still not fully understood. It has been proposed that segregation of the large membrane tyrosine phosphatase CD45 from engaged TCRs initiates signaling by favoring phosphorylation of imm
Externí odkaz:
https://doaj.org/article/24830b94ef1646cc8d43202ef6dac3e6
Akademický článek
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Autor:
Ondrej Ballek, Jan Valečka, Martina Dobešová, Adéla Broučková, Jasper Manning, Pavel Řehulka, Jiří Stulík, Dominik Filipp
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases (SFKs), Lck. Upon TCR triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that regulate the formatio
Externí odkaz:
https://doaj.org/article/f2fbc9c2880c4007849f268adc8526ba
Publikováno v:
eLife, Vol 2 (2013)
T cells discriminate between self and foreign antigenic peptides, displayed on antigen presenting cell surfaces, via the TCR. While the molecular interactions between TCR and its ligands are well characterized in vitro, quantitative measurements of t
Externí odkaz:
https://doaj.org/article/8c0ff3c12269470290cd9d2c204f613a
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
In spite of a comprehensive understanding of the schematics of T cell receptor (TCR) signaling, the mechanisms regulating compartmentalization of signaling molecules, their transient interactions and rearrangement of membrane structures initiated upo
Externí odkaz:
https://doaj.org/article/5e96e19138d14f929e1e7e0779977b9f
Autor:
Martina Dobešová, Ondřej Ballek, Jasper Manning, Adéla Broučková, Dominik Filipp, Pavel Řehulka, Jiří Stulík, Jan Valečka
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology, Vol 7 (2016)
The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases, Lck. Upon T-cell antigen receptor (TCR) triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe8f5bef7cb60c1aae9baf536c0c5ec
http://europepmc.org/articles/PMC5081367
http://europepmc.org/articles/PMC5081367