Zobrazeno 1 - 10
of 48
pro vyhledávání: '"TCR stimulation"'
Autor:
Valerie J. Brock, Niels Christian Lory, Franziska Möckl, Melina Birus, Tobias Stähler, Lena-Marie Woelk, Michelle Jaeckstein, Joerg Heeren, Friedrich Koch-Nolte, Björn Rissiek, Hans-Willi Mittrücker, Andreas H. Guse, René Werner, Björn-Philipp Diercks
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CD8+ T cells are a crucial part of the adaptive immune system, responsible for combating intracellular pathogens and tumor cells. The initial activation of T cells involves the formation of highly dynamic Ca2+ microdomains. Recently, purinergic signa
Externí odkaz:
https://doaj.org/article/a2847c04e466468e97ea1424969ec6f1
Akademický článek
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Autor:
Weihong Tian, Gaofeng Qin, Miaomiao Jia, Wuhao Li, Weili Cai, Hui Wang, Yangjing Zhao, Xuanwen Bao, Wangzhi Wei, Yu Zhang, Qixiang Shao
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The fundamental principle of immune checkpoint blockade (ICB) is to protect tumor-infiltrating T cells from being exhausted. Despite the remarkable success achieved by ICB treatment, only a small group of patients benefit from it. Characterized by a
Externí odkaz:
https://doaj.org/article/f909246f51304df39f2d11c8e8c38f7c
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109235- (2021)
Summary: T regulatory (Treg) cells are crucial to maintain immune tolerance and repress antitumor immunity, but the mechanisms governing their cellular redox homeostasis remain elusive. We report that glutathione peroxidase 4 (Gpx4) prevents Treg cel
Externí odkaz:
https://doaj.org/article/cfbc79d3e6c54ca0b5f7fe67e5ff6792
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Juewan Kim, Christopher M Hope, Griffith B Perkins, Sebastian O Stead, Jacqueline C Scaffidi, Francis D Kette, Robert P Carroll, Simon C Barry, Patrick Toby Coates
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 12, Pp n/a-n/a (2020)
Abstract Objectives Regulatory T cells (Tregs) are a vital sub‐population of CD4+ T cells with major roles in immune tolerance and homeostasis. Given such properties, the use of regulatory T cells for immunotherapies has been extensively investigat
Externí odkaz:
https://doaj.org/article/9cfb460159be4df5ac162afa53caccac
Autor:
Rubin Narayan Joshi, Charlotte Stadler, Robert Lehmann, Janne Lehtiö, Jesper Tegnér, Angelika Schmidt, Mattias Vesterlund
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
We have curated an in-depth subcellular proteomic map of primary human CD4+ T cells, divided into cytosolic, nuclear and membrane fractions generated by an optimized fractionation and HiRIEF-LC-MS/MS workflow for limited amounts of primary cells. The
Externí odkaz:
https://doaj.org/article/eb539b03081d4e91aa5c5f4e9a13e199
Autor:
Susanne G. Oberle, Layane Hanna-El-Daher, Vijaykumar Chennupati, Sarah Enouz, Stefanie Scherer, Martin Prlic, Dietmar Zehn
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 627-635 (2016)
Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens
Externí odkaz:
https://doaj.org/article/135de9931cfc469689229482bb831968
Autor:
Chun-Hao Lu, Cheng-Jang Wu, Cheng-Chi Chan, Duc T. Nguyen, Kuo-Ray Lin, Syh-Jae Lin, Li-Chen Chen, Jeffrey Jong-Yong Yen, Ming-Ling Kuo
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The master transcription factor FOXP3 regulates the differentiation, homeostasis, and suppressor function of CD4+ regulatory T (Treg) cells, which are critical in maintaining immune tolerance. Epigenetic regulation of FOXP3 expression has been demons
Externí odkaz:
https://doaj.org/article/376fb215f40c473ab10c51a6bd19e61e
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109235-(2021)
Summary: T regulatory (Treg) cells are crucial to maintain immune tolerance and repress antitumor immunity, but the mechanisms governing their cellular redox homeostasis remain elusive. We report that glutathione peroxidase 4 (Gpx4) prevents Treg cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863b0c3839e59833265047411dc1792e
https://pubmed.ncbi.nlm.nih.gov/34133924
https://pubmed.ncbi.nlm.nih.gov/34133924