Zobrazeno 1 - 10
of 75
pro vyhledávání: '"TCR signaling cascade"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Giuseppe Rubens Pascucci, Elena Morrocchi, Chiara Pighi, Arianna Rotili, Alessia Neri, Chiara Medri, Giulio Olivieri, Marco Sanna, Gianmarco Rasi, Deborah Persaud, Ann Chahroudi, Mathias Lichterfeld, Eleni Nastouli, Caterina Cancrini, Donato Amodio, Paolo Rossi, Nicola Cotugno, Paolo Palma
Publikováno v:
Biomedicines; Volume 11; Issue 3; Pages: 888
Most of the current assays directed at the investigation of HIV reactivation are based on cultures of infected cells such as Peripheral Blood Mononuclear Cells (PBMCs) or isolated CD4+ T cells, stimulated in vitro with different activator molecules.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d31a928aeca0a7581d9c77e81731426
https://doi.org/10.3390/biomedicines11030888
https://doi.org/10.3390/biomedicines11030888
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
Gluten-specific CD4+ T cells drive the pathogenesis of celiac disease and circulating gluten-specific T cells can be identified by staining with HLA-DQ:gluten tetramers. In this first single-cell RNA-seq study of tetramer-sorted T cells from untreate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2304ab7f60c78a364a2d0e064aa40070
http://europepmc.org/articles/PMC8496852
http://europepmc.org/articles/PMC8496852
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009581 (2021)
PLoS Pathogens
PLoS Pathogens
The switch between HIV latency and productive transcription is regulated by an auto-feedback mechanism initiated by the viral trans-activator Tat, which functions to recruit the host transcription elongation factor P-TEFb to proviral HIV. A heterodim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52c2ba9f29b23d318cb555f2cba070b
https://doaj.org/article/7dce3404a8e3416ab07b260d03a6cd39
https://doaj.org/article/7dce3404a8e3416ab07b260d03a6cd39
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 5, p e1007986 (2021)
PLoS Computational Biology, Vol 17, Iss 5, p e1007986 (2021)
The adaptive immune system serves as a potent and highly specific defense mechanism against pathogen infection. One component of this system, the effector T cell, facilitates pathogen clearance upon detection of specific antigens by the T cell recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda4c0fcff2b9572abcf97a8285316a9
http://europepmc.org/articles/PMC8184007
http://europepmc.org/articles/PMC8184007
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3001272 (2021)
PLoS Biology
PLoS Biology
Programmed cell death protein 1 (PD-1) is expressed on T cells upon T cell receptor (TCR) stimulation. PD-1 ligand 1 (PD-L1) is expressed in most tumor environments, and its binding to PD-1 on T cells drives them to apoptosis or into a regulatory phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddbc3bec832f49a1b4044a6769953c6
https://doaj.org/article/5e3b170e925c4a47a8f101b4e0f615b3
https://doaj.org/article/5e3b170e925c4a47a8f101b4e0f615b3
Autor:
Gaelle Dzangue-Tchoupou, Olivier Vittecoq, Céline Derambure, Maria Antonietta D'Agostino, Thierry Lequerré
Publikováno v:
PLoS ONE
PLoS ONE, 2020, 15 (8), pp.e0237143. ⟨10.1371/journal.pone.0237143⟩
PLoS ONE, Public Library of Science, 2020, 15 (8), pp.e0237143. ⟨10.1371/journal.pone.0237143⟩
PLoS ONE, Vol 15, Iss 8, p e0237143 (2020)
PLoS ONE, 2020, 15 (8), pp.e0237143. ⟨10.1371/journal.pone.0237143⟩
PLoS ONE, Public Library of Science, 2020, 15 (8), pp.e0237143. ⟨10.1371/journal.pone.0237143⟩
PLoS ONE, Vol 15, Iss 8, p e0237143 (2020)
International audience; Objectives: Abatacept acts as a competitive inhibitor of the CD28/(CD80/86) costimulation signal required for T cell activation. Mechanisms of action of abatacept have not been fully investigated. The objective of this study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50868d5bb543e0fd8976f45c8c6d398a
https://www.hal.inserm.fr/inserm-02973841/document
https://www.hal.inserm.fr/inserm-02973841/document
Autor:
Yibo Zuo, Tingting Guo, Ying Miao, Chuanwu Zhu, Hui Zheng, Liting Zhang, Hong-Guang Zhang, Li Zhu, Xiangjie Chen, Fan Huang, Qian Feng, Lincong Jin, Jin Liu, Yukang Yuan, Feng Qian
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 1, p e1008215 (2020)
PLoS Pathogens, Vol 16, Iss 1, p e1008215 (2020)
CREB-binding protein (CBP) participates in numerous transcription events. However, cell-intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts with the HAT domain of CBP and inhibits CBP’s acetyltransferase act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09116da0bc8716eaa14b42f121f996e4
http://europepmc.org/articles/PMC6961928
http://europepmc.org/articles/PMC6961928
Autor:
Sanjay de Mel, Nurulhuda Mustafa, Viknesvaran Selvarajan, Muhammad Irfan Azaman, Patrick William Jaynes, Shruthi Venguidessane, Hoang Mai Phuong, Zubaida Talal Alnaseri, The Phyu, Louis-Pierre Girard, Wee Joo Chng, Joanna Wardyn, Ying Li, Omer An, Henry Yang, Siok Bian Ng, Anand D. Jeyasekharan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0261469 (2022)
PLoS ONE, Vol 17, Iss 1, p e0261469 (2022)
B-cell receptor (BCR) signalling is critical for the survival of B-cell lymphomas and is a therapeutic target of drugs such as Ibrutinib. However, the role of T-cell receptor (TCR) signalling in the survival of T/Natural Killer (NK) lymphomas is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d2e8114d59ba8e0d079e098ec6c682
https://doi.org/10.1371/journal.pone.0261469
https://doi.org/10.1371/journal.pone.0261469
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 9, p e1007338 (2019)
PLoS Computational Biology, Vol 15, Iss 9, p e1007338 (2019)
T cells use their T-cell receptors (TCRs) to scan other cells for antigenic peptides presented by MHC molecules (pMHC). If a TCR encounters a pMHC, it can trigger a signalling pathway that could lead to the activation of the T cell and the initiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ad6d36330c581a4553d0df39b59189
http://europepmc.org/articles/PMC6752857
http://europepmc.org/articles/PMC6752857