Zobrazeno 1 - 10
of 65
pro vyhledávání: '"TCR engineering"'
Publikováno v:
Vaccines, Vol 11, Iss 4, p 835 (2023)
T cells are critical in destroying cancer cells by recognizing antigens presented by MHC molecules on cancer cells or antigen-presenting cells. Identifying and targeting cancer-specific or overexpressed self-antigens is essential for redirecting T ce
Externí odkaz:
https://doaj.org/article/6963c7620c1a4af89d484dc0b15d4060
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunotherapy of cancer has made tremendous progress in recent years, as demonstrated by the remarkable clinical responses obtained from adoptive cell transfer (ACT) of patient-derived tumor infiltrating lymphocytes, chimeric antigen receptor (CAR)-m
Externí odkaz:
https://doaj.org/article/aeae607204604604ba44e49ef168eb52
Autor:
Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Wouter Scheper, Laura Bongiovanni, Alain de Bruin, Dennis X. Beringer, Rimke Oostvogels, Trudy Straetemans, Zsolt Sebestyen, Jürgen Kuball
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
γδT cell receptors (γδTCRs) recognize a broad range of malignantly transformed cells in mainly a major histocompatibility complex (MHC)-independent manner, making them valuable additions to the engineered immune effector cell therapy that current
Externí odkaz:
https://doaj.org/article/e17f0e99771741b296928ed52e569024
Akademický článek
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Autor:
Enas Abu-Shah, Philippos Demetriou, Štefan Bálint, Viveka Mayya, Mikhail A Kutuzov, Omer Dushek, Michael L Dustin
Publikováno v:
eLife, Vol 8 (2019)
Research in the field of human immunology is restricted by the lack of a system that reconstitutes the in-situactivation dynamics of quiescent human antigen-specific T-cells interacting with dendritic cells. Here we report a tissue-like system that r
Externí odkaz:
https://doaj.org/article/7078a64cb83b480cb219dd2e3e856c67
Autor:
Aubin, Marie-France
La leucémie aigüe myéloïde est un cancer hautement létal notamment parce que le taux de rechutes est élevé, ce qui traduit l’importance du développement de nouvelles thérapies. Ces dernières peuvent tirer avantage du fait que les cellule
Externí odkaz:
http://hdl.handle.net/1866/28411
Publikováno v:
Cells, Vol 9, Iss 7, p 1720 (2020)
Over the past decades, adoptive transfer of T cells has revolutionized cancer immunotherapy. In particular, T-cell receptor (TCR) engineering of T cells has marked important milestones in developing more precise and personalized cancer immunotherapie
Externí odkaz:
https://doaj.org/article/a94512b929b54947b8608002e1ff9d62
Publikováno v:
Cells, Vol 9, Iss 6, p 1367 (2020)
Natural adaptive immunity co-evolved with pathogens over millions of years, and adoptive transfer of non-engineered T cells to fight infections or cancer so far exhibits an exceptionally safe and functional therapeutic profile in clinical trials. How
Externí odkaz:
https://doaj.org/article/fc1505a8836d4a05a25c00bf46f19c32
The unconventional γδT cells share the property of innate and adaptive immunity that allows recognition of infected, stress-induced, and malignantly-transformed cells and undergo clonal expansion and memory formation. γδT cells recognize infected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::4234fbf9441d52b3ab1ac5f7f73aa6fc
https://doi.org/10.33540/948
https://doi.org/10.33540/948
Autor:
Johanna Gan, Inez
The unconventional γδT cells share the property of innate and adaptive immunity that allows recognition of infected, stress-induced, and malignantly-transformed cells and undergo clonal expansion and memory formation. γδT cells recognize infected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6efe14a889d1bc4503cbac0722d9e7aa
https://dspace.library.uu.nl/handle/1874/406970
https://dspace.library.uu.nl/handle/1874/406970