Zobrazeno 1 - 10
of 118
pro vyhledávání: '"TCR affinity"'
Akademický článek
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Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Affinity-optimized T cell receptor (TCR)-engineered lymphocytes targeting tumor antigens can mediate potent antitumor responses in cancer patients, but also bear substantial risks for off-target toxicities. Most preclinical studie
Externí odkaz:
https://doaj.org/article/f611af4ae501422cbc012cdd8ddf0721
Akademický článek
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Autor:
Nayan D. Bhattacharyya, Carl G. Feng
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
T cells are critical in orchestrating protective immune responses to cancer and an array of pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting cells (APCs) and T cell receptors (TCRs) on T cells initiates T cell act
Externí odkaz:
https://doaj.org/article/e33e36b025ac4ddbbaef4e900e6f34a2
Contribution of T Cell Receptor Affinity to Overall Avidity for Virus-Specific CD8+ T Cell Responses
Autor:
Kedzierska, Katherine, La Gruta, Nicole L., Davenport, Miles P., Turner, Stephen J., Doherty, Peter C.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2005 Aug 01. 102(32), 11432-11437.
Externí odkaz:
https://www.jstor.org/stable/3376284
Publikováno v:
Cells, Vol 9, Iss 7, p 1720 (2020)
Over the past decades, adoptive transfer of T cells has revolutionized cancer immunotherapy. In particular, T-cell receptor (TCR) engineering of T cells has marked important milestones in developing more precise and personalized cancer immunotherapie
Externí odkaz:
https://doaj.org/article/a94512b929b54947b8608002e1ff9d62
Publikováno v:
European Journal of Immunology
The functional avidity (FA) of cytotoxic CD8 T cells impacts strongly on their functional capabilities and correlates with protection from infection and cancer. FA depends on TCR affinity, downstream signaling strength, and TCR affinity‐independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e78c5e0b495d663444b6e600c32ef26
https://doi.org/10.1002/eji.202049016
https://doi.org/10.1002/eji.202049016
Autor:
Urmann, Emanuel
A characteristic of the adaptive immune system is the random composition of the antigen receptor repertoire. This potentially allows recognition of any pathogen. Yet statistically, autoreactive immune cells are also generated which, when not removed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbea32fcb81cf6b0a9350ebb69a12399
Publikováno v:
Genomics Data, Vol 2, Iss C, Pp 396-398 (2014)
Clonal population expansion of T cells during an immune response is dependent on the affinity of the T cell receptor (TCR) for its antigen [1]. However, there is little understanding of how this process is controlled transcriptionally. We found that
Externí odkaz:
https://doaj.org/article/4bb6b1c50d2b43a9b4991208fff8fc10
Autor:
Michaël eHebeisen, Mathilde eAllard, Philippe eGannon, Julien eSchmidt, Daniel Ernst Speiser, Nathalie eRufer
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Cytotoxic T cells recognize, via their T cell receptors (TCRs), small antigenic peptides presented by the Major Histocompatibility Complex (pMHC) on the surface of professional antigen presenting cells (APC), and infected or malignant cells. The effi
Externí odkaz:
https://doaj.org/article/9a0fe7997da141da82d7ee66711e68a3