Zobrazeno 1 - 10
of 467
pro vyhledávání: '"TCR - T cell receptor"'
Autor:
Maya Haus-Cohen, Yoram Reiter
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The clinical success of cancer immunotherapy has driven ongoing efforts to identify novel targets that can effectively guide potent effector functions to eliminate malignant cells. Traditionally, immunotherapies have focused on surface antigens; howe
Externí odkaz:
https://doaj.org/article/503eee7d55634cd5a7d37e8ca0795a8c
Autor:
Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily P. S. Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M. Denham, Giulia Masi, Phyllis Tea Qing Yun, Colin Moore, Selsabil Dhaouadi, Gurdyal S. Besra, Natacha Veerapen, Patricia T. Illing, Julian P. Vivian, Jeremy M. Raynes, Jérôme Le Nours, Anthony W. Purcell, Samit Kundu, Jonathan D. Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Duncan Howie, Joseph Dukes
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection.
Externí odkaz:
https://doaj.org/article/8f539e9eaf5e40e19fbc3e2c06f07574
Autor:
Abdullah Degirmencay, Sharyn Thomas, Angelika Holler, Samuel Burgess, Emma C. Morris, Hans J. Stauss
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The expression levels of TCRs on the surface of human T cells define the avidity of TCR-HLA/peptide interactions. In this study, we have explored which components of the TCR-CD3 complex are involved in determining the surface expression levels of TCR
Externí odkaz:
https://doaj.org/article/8025343ede7741d989be0574485bfd42
Autor:
Nadine M. Woessner, Simon M. Brandl, Sara Hartmann, Wolfgang W. Schamel, Frederike A. Hartl, Susana Minguet
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAntigen binding to the T cell antigen receptor (TCR) leads to the phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 complex, and thereby to T cell activation. The CD3ε subunit plays a unique role i
Externí odkaz:
https://doaj.org/article/0a1412bd5d8541f29df79e6652127bbd
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Non-mutated FVIII-specific CD4 T cell epitopes have been recently found to contribute to the development of inhibitors in patients with hemophilia A (HA), while auto-reactive CD4 T cells specific to FVIII circulate in the blood of healthy individuals
Externí odkaz:
https://doaj.org/article/73797c65c3b543d0848c1d94104098aa
Autor:
Beatrice Claudia Cianciotti, Zulma Irene Magnani, Alessia Ugolini, Barbara Camisa, Ivan Merelli, Valentina Vavassori, Alessia Potenza, Antonio Imparato, Francesco Manfredi, Danilo Abbati, Laura Perani, Antonello Spinelli, Eric Shifrut, Fabio Ciceri, Luca Vago, Raffaella Di Micco, Luigi Naldini, Pietro Genovese, Eliana Ruggiero, Chiara Bonini
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIn adoptive T cell therapy, the long term therapeutic benefits in patients treated with engineered tumor specific T cells are limited by the lack of long term persistence of the infused cellular products and by the immunosuppressive mechani
Externí odkaz:
https://doaj.org/article/0c75a1d1ee5c498d8c626e70eae69c03
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/a8377297a9a64533b9c80e019abccd62
Autor:
M. Eyad Khorki, Tiffany Shi, Eileen E. Cianciolo, Ashley R. Burg, P. Chukwunalu Chukwuma, Jennifer L. Picarsic, Mary K. Morrice, E. Steve Woodle, Jonathan S. Maltzman, Autumn Ferguson, Jonathan D. Katz, Brian M. Baker, David A. Hildeman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSignificant evidence suggests a connection between transplant rejection and the presence of high levels of pre-existing memory T cells. Viral infection can elicit viral-specific memory T cells that cross-react with allo-MHC capable of dri
Externí odkaz:
https://doaj.org/article/555d23a18c6843c39ebce9e0a10efea5
Autor:
Annekathrin Silvia Nedwed, Sara Salome Helbich, Kathrin Luise Braband, Michael Volkmar, Michael Delacher, Federico Marini
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Single-cell gene expression analysis using sequencing (scRNA-seq) has gained increased attention in the past decades for studying cellular transcriptional programs and their heterogeneity in an unbiased manner, and novel protocols allow the simultane
Externí odkaz:
https://doaj.org/article/6fbd80adbe7243288f37cfe9adf76ebb
Autor:
Martina Kunkl, Carola Amormino, Francesco Spallotta, Silvana Caristi, Maria Teresa Fiorillo, Alessandro Paiardini, Raymond Kaempfer, Loretta Tuosto
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/7398ad673f554322845e852eaafa09cc