Zobrazeno 1 - 10
of 18 411
pro vyhledávání: '"TCR"'
Autor:
Fernando Marín-Benesiu, Lucia Chica-Redecillas, Verónica Arenas-Rodríguez, Esperanza de Santiago, Silvia Martínez-Diz, Ginesa López-Torres, Ana Isabel Cortés-Valverde, Catalina Romero-Cachinero, Carmen Entrala-Bernal, Francisco Javier Fernandez-Rosado, Luis Javier Martínez-González, Maria Jesus Alvarez-Cubero
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-11 (2024)
Abstract Background The architecture and dynamics of T cell populations are critical in orchestrating the immune response to SARS-CoV-2. In our study, we used T Cell Receptor sequencing (TCRseq) to investigate TCR repertoires in 173 post-infection CO
Externí odkaz:
https://doaj.org/article/6e8cafa863ab40ca833c218b94590149
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract At the 3’ end of the C2 gene in the mammalian TRB locus, a distinct reverse TRBV30 gene (named TRBV31 in mice) has been conserved throughout evolution. In the fully annotated TRB locus of 14 mammals (including six orders), we observed note
Externí odkaz:
https://doaj.org/article/6d14b75e05fc4d33a512763f3c460800
Autor:
Kaiyue Zhou, Zhengliang Xiao, Qi Liu, Xu Wang, Jiaxin Huo, Xiaoqi Wu, Xiaoxiao Zhao, Xiaohan Feng, Baoyi Fu, Pengfei Xu, Yunyun Deng, Wenwen Xiao, Tao Sun, Lin Da
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract T-cell receptor (TCR) detection can examine the extent of T-cell immune responses. Therefore, the article analyzed characteristic data of glioma obtained by DNA-based TCR high-throughput sequencing, to predict the disease with fewer biomarke
Externí odkaz:
https://doaj.org/article/7cfb84388f4d466195a9e296e77d37ec
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 663-674 (2024)
Adoptive cell therapies involve infusing engineered immune cells into cancer patients to recognize and eliminate tumor cells. Adoptive cell therapy, as a form of living drug, has undergone explosive growth over the past decade. The recognition of tum
Externí odkaz:
https://doaj.org/article/b2f6eab4a792471bbfc2d195b0210302
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cell receptors (TCRs) play crucial roles in regulating T cell response by rapidly and accurately recognizing foreign and non-self antigens. The process involves multiple molecules and regulatory mechanisms, forming a complex network to achieve effe
Externí odkaz:
https://doaj.org/article/e8b96d605f664a2ca35e015a68ce6144
Autor:
Xin Yang, Changchun Wu, Wenwen Liu, Kaiyu Fu, Yuke Tian, Xing Wei, Wei Zhang, Ping Sun, Huaichao Luo, Jian Huang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 24, Iss , Pp 404-411 (2024)
Lung cancer is the main cause of cancer-related deaths worldwide. Due to lack of obvious clinical symptoms in the early stage of the lung cancer, it is hard to distinguish between malignancy and pulmonary nodules. Understanding the immune responses i
Externí odkaz:
https://doaj.org/article/e98f384dba6947bfb42f0e585b5688f4
Publikováno v:
Cardio-Oncology, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Purpose Immune checkpoint inhibitors (ICIs)-associated myocarditis was a rare yet severe complication observed in individuals undergoing immunotherapy. This study investigated the immune status and characteristics of patients diagnosed with
Externí odkaz:
https://doaj.org/article/f7e8e12f5f334abcaedf51182ba7f9d9
Autor:
Eric Dumonteil, Weihong Tu, Hans Desale, Kelly Goff, Preston Marx, Jaime Ortega-Lopez, Claudia Herrera
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-11 (2024)
Abstract Background A vaccine against Trypanosoma cruzi, the agent of Chagas disease, would be an excellent additional tool for disease control. A recombinant vaccine based on Tc24 and TSA1 parasite antigens was found to be safe and immunogenic in na
Externí odkaz:
https://doaj.org/article/ed8fb005e1f24898a561b81c072d525e
Autor:
Libuse Lizcova, Eva Prihodova, Lenka Pavlistova, Karla Svobodova, Ester Mejstrikova, Ondrej Hrusak, Pavla Luknarova, Iveta Janotova, Lucie Sramkova, Jan Stary, Zuzana Zemanova
Publikováno v:
Molecular Cytogenetics, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) represents a rare and clinically and genetically heterogeneous disease that constitutes 10–15% of newly diagnosed pediatric ALL cases. Despite improved outcomes of these children, the
Externí odkaz:
https://doaj.org/article/dd9bf69a7ebc4b1da84c61d75b2dbb82