Zobrazeno 1 - 10
of 18 343
pro vyhledávání: '"TCR"'
Autor:
Hsiu-Chun Chuang, Ruidong Li, Huang Huang, Szu-Wen Liu, Christine Wan, Subhra Chaudhuri, Lili Yue, Terence Wong, Venina Dominical, Randy Yen, Olivia Ngo, Nam Bui, Hubert Stoppler, Tangsheng Yi, Silpa Suthram, Li Li, Kai-Hui Sun
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract We developed an automated high-throughput Smart-seq3 (HT Smart-seq3) workflow that integrates best practices and an optimized protocol to enhance efficiency, scalability, and method reproducibility. This workflow consistently produces high-q
Externí odkaz:
https://doaj.org/article/2b56699385fd48abb9748547bae2c25e
Autor:
Akira Saito, Toshiyuki Koya, Ami Aoki, Shun Naramoto, Hiroshi Ueno, Yuki Nishiyama, Kenjiro Shima, Yosuke Kimura, Takashi Hasegawa, Satoshi Watanabe, Yasuyoshi Ohshima, Keisuke Suzuki, Katsuyo Ohashi-Doi, Toshiaki Kikuchi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Sublingual immunotherapy (SLIT) has received considerable attention as a method for allergen immunotherapy (AIT). However, the mechanism of SLIT, especially its timing, has not been thoroughly investigated. We evaluated therapeutic and proph
Externí odkaz:
https://doaj.org/article/fd44cc5a7c2948bdbfcbaa10a6749b99
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract The quality of Recombination signal sequences (RSSs), location, and genetics of mammalian V, D, and J genes synergistically affect the recombination frequency of genes; however, the specific regulatory mechanism and efficiency have not been
Externí odkaz:
https://doaj.org/article/4400dea2c1cc4bc9802926bdd3af8367
Autor:
Elena A. Golikova, Alina A. Alshevskaya, Saleh Alrhmoun, Natalia A. Sivitskaya, Sergey V. Sennikov
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract TCR-T cell therapy represents a promising advancement in adoptive immunotherapy for cancer treatment. Despite its potential, the development and preclinical testing of TCR-T cells face significant challenges. This review provides a structure
Externí odkaz:
https://doaj.org/article/5b713d088eb846389f371cede8d9d4c7
Autor:
Virginia Ruiz-Martín, Tamara Marcos, José María de Pereda, Mariano Sánchez-Crespo, Miguel Angel de la Fuente, Yolanda Bayón, Andrés Alonso
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-14 (2024)
Abstract Background The LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and promotes the develop
Externí odkaz:
https://doaj.org/article/499a1f4142394707ab2ef870ecc4c351
Autor:
Fernando Marín-Benesiu, Lucia Chica-Redecillas, Verónica Arenas-Rodríguez, Esperanza de Santiago, Silvia Martínez-Diz, Ginesa López-Torres, Ana Isabel Cortés-Valverde, Catalina Romero-Cachinero, Carmen Entrala-Bernal, Francisco Javier Fernandez-Rosado, Luis Javier Martínez-González, Maria Jesus Alvarez-Cubero
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-11 (2024)
Abstract Background The architecture and dynamics of T cell populations are critical in orchestrating the immune response to SARS-CoV-2. In our study, we used T Cell Receptor sequencing (TCRseq) to investigate TCR repertoires in 173 post-infection CO
Externí odkaz:
https://doaj.org/article/6e8cafa863ab40ca833c218b94590149
Autor:
Maya Haus-Cohen, Yoram Reiter
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The clinical success of cancer immunotherapy has driven ongoing efforts to identify novel targets that can effectively guide potent effector functions to eliminate malignant cells. Traditionally, immunotherapies have focused on surface antigens; howe
Externí odkaz:
https://doaj.org/article/503eee7d55634cd5a7d37e8ca0795a8c
Autor:
Sergey Sennikov, Marina Volynets, Saleh Alrhmoun, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Marina Fisher, Julia Lopatnikova, Julia Shevchenko, Kirill Nazarov, Julia Philippova, Alaa Alsalloum, Vasily Kurilin, Alexander Silkov
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAdoptive cell therapy using TCR-engineered T-cells is one of the most effective strategies against tumor cells. The TCR T-cell approach has been well tested against a variety of blood neoplasms but is yet to be deeply tested against solid
Externí odkaz:
https://doaj.org/article/433d45dbd46f482299d490a3b9a17848
Autor:
Shasha Deng, Zhihao Xu, Jing Hu, Yunru Yang, Fang Zhu, Zhuan Liu, Hongliang Zhang, Songquan Wu, Tengchuan Jin
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cytotoxic CD8+ T lymphocytes (CTLs) have been implicated in the severity of COVID-19. The TCR-pMHC ternary complex, formed by the T cell receptor (TCR) and peptide-MHC (major histocompatibility complex), constitutes the molecular basis of CTL respons
Externí odkaz:
https://doaj.org/article/cb3aab4ce4d94754899f8b5f713c1626
