Per-cell histone acetylation is associated with terminal differentiation in human T cells

Autor: Cheng Yang, You Li, Yaqiu Hu, Qian Li, Yinghua Lan, Yongguo Li

Publikováno v: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-10 (2024)

Abstract Background Epigenetic remodeling at effector gene loci has been reported to be critical in regulating T cell differentiation and function. However, efforts to investigate underlying epigenetic mechanisms that control T cell behaviors have be

Externí odkaz: https://doaj.org/article/f0ae2805cce347a5a9762ff133689a25

Beyond checkpoint inhibition: PD-1 cis-targeting of an IL-2Rβγ-biased interleukin-2 variant as a novel approach to build on checkpoint inhibition

Autor: Laura Codarri Deak, Masao Hashimoto, Pablo Umaña, Christian Klein

Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)

ABSTRACTThe immunocytokine PD1-IL2v was designed to overcome liabilities and improve efficacy of IL-2 therapies. PD1-IL2v preferentially targets PD-1+ T-cells and acts on antigen-specific stem-like PD-1+ TCF-1+ CD8+ T-cells expanding and differentiat

Externí odkaz: https://doaj.org/article/309d650fc20346a19de0ef750266fa1d

CD4+ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss

Autor: Tom Hofland, Luca Danelli, Georgina Cornish, Tiziano Donnarumma, Deborah M. Hunt, Luiz P. S. de Carvalho, George Kassiotis

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

CD4+ T cells are typically considered as ‘helper’ or ‘regulatory’ populations that support and orchestrate the responses of other lymphocytes. However, they can also develop potent granzyme (Gzm)-mediated cytotoxic activity and CD4+ cytotoxic

Externí odkaz: https://doaj.org/article/5ac6f82a4af34bec92313e0da9ee0424

Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells

Autor: Hiroshi Takata, Juyeon C. Kakazu, Julie L. Mitchell, Eugene Kroon, Donn J. Colby, Carlo Sacdalan, Hongjun Bai, Philip K. Ehrenberg, Aviva Geretz, Supranee Buranapraditkun, Suteeraporn Pinyakorn, Jintana Intasan, Somporn Tipsuk, Duanghathai Suttichom, Peeriya Prueksakaew, Thep Chalermchai, Nitiya Chomchey, Nittaya Phanuphak, Mark de Souza, Nelson L. Michael, Merlin L. Robb, Elias K. Haddad, Trevor A Crowell, Sandhya Vasan, Victor G. Valcour, Daniel C. Douek, Rasmi Thomas, Morgane Rolland, Nicolas Chomont, Jintanat Ananworanich, Lydie Trautmann, Nipat Teeratakulpisarn, Supanit Pattanachaiwit, Somchai Sriplienchan, Ponpen Tantivitayakul, Ratchapong Kanaprach, Kiat Ruxrungtham, Netsiri Dumrongpisutikul, Ponlapat Rojnuckarin, Suthat Chottanapund, Kultida Poltavee, Tassanee Luekasemsuk, Hathairat Savadsuk, Suwanna Puttamsawin, Khunthalee Benjapornpong, Nisakorn Ratnaratorn, Kamonkan Tangnaree, Chutharat Munkong, Rommanus Thaimanee, Patcharin Eamyoung, Sasiwimol Ubolyam, Sukalya Lerdlum, Sopark Manasnayakorn, Rugsun Rerknimitr, Sunee Sirivichayakul, Phandee Wattanaboonyongcharoen, Jessica Cowden, Alexandra Schuetz, Siriwat Akapirat, Nampueng Churikanont, Saowanit Getchalarat, Denise Hsu, Ellen Turk, Oratai Butterworth, Mark Milazzo, Leigh Anne Eller, Julie Ake, Serena Spudich, CAPT Lawrence Fox, Silvia Ratto-Kim, Victor DeGruttola, Yotin Chinvarun, Pasiri Sithinamsuwan, James Fletcher, Bruce Shiramizu

Publikováno v: EBioMedicine, Vol 84, Iss , Pp 104253- (2022)

Summary: Background: Harnessing CD8+ T cell responses is being explored to achieve HIV remission. Although HIV-specific CD8+ T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the

Externí odkaz: https://doaj.org/article/9613185aa1dd427ea563c0aff33f6788

The kinase PDK1 is critical for promoting T follicular helper cell differentiation

Autor: Zhen Sun, Yingpeng Yao, Menghao You, Jingjing Liu, Wenhui Guo, Zhihong Qi, Zhao Wang, Fang Wang, Weiping Yuan, Shuyang Yu

Publikováno v: eLife, Vol 10 (2021)

The kinase PDK1 is a crucial regulator for immune cell development by connecting PI3K to downstream AKT signaling. However, the roles of PDK1 in CD4+ T cell differentiation, especially in T follicular helper (Tfh) cell, remain obscure. Here we report

Externí odkaz: https://doaj.org/article/3d7b3fd7a9d84ef6a4d02f38d3187947