Per-cell histone acetylation is associated with terminal differentiation in human T cells

Autor: Cheng Yang, You Li, Yaqiu Hu, Qian Li, Yinghua Lan, Yongguo Li

Publikováno v: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-10 (2024)

Abstract Background Epigenetic remodeling at effector gene loci has been reported to be critical in regulating T cell differentiation and function. However, efforts to investigate underlying epigenetic mechanisms that control T cell behaviors have be

Externí odkaz: https://doaj.org/article/f0ae2805cce347a5a9762ff133689a25

Beyond checkpoint inhibition: PD-1 cis-targeting of an IL-2Rβγ-biased interleukin-2 variant as a novel approach to build on checkpoint inhibition

Autor: Laura Codarri Deak, Masao Hashimoto, Pablo Umaña, Christian Klein

Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)

ABSTRACTThe immunocytokine PD1-IL2v was designed to overcome liabilities and improve efficacy of IL-2 therapies. PD1-IL2v preferentially targets PD-1+ T-cells and acts on antigen-specific stem-like PD-1+ TCF-1+ CD8+ T-cells expanding and differentiat

Externí odkaz: https://doaj.org/article/309d650fc20346a19de0ef750266fa1d

Lymphoid tissue residency: A key to understand Tcf-1+PD-1+ T cells

Autor: Chaoyu Ma, Nu Zhang

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

During chronic antigen exposure, a subset of exhausted CD8+ T cells differentiate into stem cell-like or progenitor-like T cells expressing both transcription factor Tcf-1 (T cell factor-1) and co-inhibitory receptor PD-1. These Tcf-1+ stem-like or p

Externí odkaz: https://doaj.org/article/6c7998d4fc0547dd8c0db0c24ac75115

Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells

Autor: Hiroshi Takata, Juyeon C. Kakazu, Julie L. Mitchell, Eugene Kroon, Donn J. Colby, Carlo Sacdalan, Hongjun Bai, Philip K. Ehrenberg, Aviva Geretz, Supranee Buranapraditkun, Suteeraporn Pinyakorn, Jintana Intasan, Somporn Tipsuk, Duanghathai Suttichom, Peeriya Prueksakaew, Thep Chalermchai, Nitiya Chomchey, Nittaya Phanuphak, Mark de Souza, Nelson L. Michael, Merlin L. Robb, Elias K. Haddad, Trevor A Crowell, Sandhya Vasan, Victor G. Valcour, Daniel C. Douek, Rasmi Thomas, Morgane Rolland, Nicolas Chomont, Jintanat Ananworanich, Lydie Trautmann, Nipat Teeratakulpisarn, Supanit Pattanachaiwit, Somchai Sriplienchan, Ponpen Tantivitayakul, Ratchapong Kanaprach, Kiat Ruxrungtham, Netsiri Dumrongpisutikul, Ponlapat Rojnuckarin, Suthat Chottanapund, Kultida Poltavee, Tassanee Luekasemsuk, Hathairat Savadsuk, Suwanna Puttamsawin, Khunthalee Benjapornpong, Nisakorn Ratnaratorn, Kamonkan Tangnaree, Chutharat Munkong, Rommanus Thaimanee, Patcharin Eamyoung, Sasiwimol Ubolyam, Sukalya Lerdlum, Sopark Manasnayakorn, Rugsun Rerknimitr, Sunee Sirivichayakul, Phandee Wattanaboonyongcharoen, Jessica Cowden, Alexandra Schuetz, Siriwat Akapirat, Nampueng Churikanont, Saowanit Getchalarat, Denise Hsu, Ellen Turk, Oratai Butterworth, Mark Milazzo, Leigh Anne Eller, Julie Ake, Serena Spudich, CAPT Lawrence Fox, Silvia Ratto-Kim, Victor DeGruttola, Yotin Chinvarun, Pasiri Sithinamsuwan, James Fletcher, Bruce Shiramizu

Publikováno v: EBioMedicine, Vol 84, Iss , Pp 104253- (2022)

Summary: Background: Harnessing CD8+ T cell responses is being explored to achieve HIV remission. Although HIV-specific CD8+ T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the

Externí odkaz: https://doaj.org/article/9613185aa1dd427ea563c0aff33f6788

TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity

Autor: Mahinbanu Mammadli, Liye Suo, Jyoti Misra Sen, Mobin Karimi

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 5, p 4326 (2023)

The transcription factor T cell factor-1 (TCF-1) is encoded by Tcf7 and plays a significant role in regulating immune responses to cancer and pathogens. TCF-1 plays a central role in CD4 T cell development; however, the biological function of TCF-1 o

Externí odkaz: https://doaj.org/article/3026142f20db41239dc7d41eaebd6e16