Zobrazeno 1 - 10
of 2 086
pro vyhledávání: '"TBK1"'
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-15 (2024)
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) has led to significant economic losses in the global swine industry. Type I interferon (IFN-I) plays a crucial role in the host’s resistance to PRRSV infection. Despite extensive
Externí odkaz:
https://doaj.org/article/c697a7962f2d4831be10d9b1c7d54f55
Autor:
Wenfeng He, Hongtao Chang, Chen Li, Chenlong Wang, Longxi Li, Guoqing Yang, Jing Chen, Huimin Liu
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Serine/threonine kinase receptor-associated protein (STRAP) serves as a scaffold protein and is engaged in a variety of cellular activities, although its importance in antiviral innate immunity is unknown. We discovered that STRAP works as a
Externí odkaz:
https://doaj.org/article/0c9f80c5a4bf4a5fbf61616e629fd137
Publikováno v:
Guangdong nongye kexue, Vol 51, Iss 7, Pp 151-160 (2024)
【Objective】Tembusu virus (TMUV) disease is an important infectious disease in waterfowl. In previous studies, we found that in the early stages of TMUV infection in ducks, the viral copy number of group 2 TMUV in organs such as the liver, kidney,
Externí odkaz:
https://doaj.org/article/d606c75e1f364346a76b617122c9f746
Autor:
Xiao Li, Kai Cheng, Meng-Di Shang, Yong Yang, Bin Hu, Xi Wang, Xiao-Dan Wei, Yan-Chun Han, Xiao-Gang Zhang, Meng-Hua Dong, Zhen-Lin Yang, Jiu-Qiang Wang
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background TBK1 positively regulates the growth factor-mediated mTOR signaling pathway by phosphorylating mTOR. However, it remains unclear how the TBK1-mTOR signaling pathway is regulated. Considering that STING not only interacts with TBK1
Externí odkaz:
https://doaj.org/article/c13acb335ac04ab9ae46c41fd07f1121
Autor:
Qinming Liao, Yimei Yang, Yilu Li, Jun Zhang, Keke Fan, Yihao Guo, Jun Chen, Yinhao Chen, Pian Zhu, Lijin Huang, Zhongjie Liu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Painful diabetic neuropathy (PDN) is closely linked to inflammation, which has been demonstrated to be associated with pyroptosis. Emerging evidence has implicated TANK-binding kinase 1 (TBK1) in various inflammatory diseases. How
Externí odkaz:
https://doaj.org/article/ae09029f49884c339c0e6b9223b9ec17
Autor:
Rui Lu, Yunkun Qu, Zhenggang Wang, Zhiyi He, Shimeng Xu, Peng Cheng, Zhengtao Lv, Hongbo You, Fengjing Guo, Anmin Chen, Jiaming Zhang, Shuang Liang
Publikováno v:
Journal of Orthopaedic Translation, Vol 47, Iss , Pp 207-222 (2024)
Objectives: TANK-binding kinase 1 (TBK1) is pivotal in autoimmune and inflammatory diseases, yet its role in osteoarthritis (OA) remains elusive. This study sought to elucidate the effect of the TBK1 inhibitor BX795 on OA and to delineate the underly
Externí odkaz:
https://doaj.org/article/fede2b11d8404b65a820a8cbf5153851
Autor:
Haitian Nan, Yeon-Jeong Kim, Min Chu, Dan Li, Jieying Li, Deming Jiang, Yiming Wu, Toshihisa Ohtsuka, Liyong Wu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Our study aims to evaluate the genetic and phenotypic spectrum of Frontotemporal dementia (FTD) gene variant carriers in Chinese populations, investigate mutation frequencies, and assess the functional properties of TBK1 and OPTN
Externí odkaz:
https://doaj.org/article/90adb931fafc4c478550548d8c52986b
Autor:
Lianxin Hu, Qing Zhang
Publikováno v:
Cell Insight, Vol 3, Iss 5, Pp 100197- (2024)
TANK-binding kinase 1 (TBK1) is a serine/threonine kinase with well-established roles as a central player in innate immune signaling. Dysregulation of TBK1 activity has been implicated in a variety of pathophysiologic conditions, including cancer. Ge
Externí odkaz:
https://doaj.org/article/981f5ab23ded40578891f6361bb16f62
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
TANK-binding kinase 1 (TBK1) is a member of the IKK family and plays a crucial role in the activation of non-canonical NF-κB signaling and type I interferon responses. The aberrant activation of TBK1 contributes to the proliferation and survival of
Externí odkaz:
https://doaj.org/article/e06587c56e054021b2127fe5b3b9e97f
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 3, Pp 301-311 (2024)
Objective·To analyze the relationship between the expression level of interferon regulatory factor 3 (IRF3) in colorectal cancer and its clinicopathological features and prognosis, and to observe the effects of IRF3 overexpression on the proliferati
Externí odkaz:
https://doaj.org/article/1c1fe6d32aac4a4aaca33dd70ff94f6f