Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing

Autor: Bappaditya Dey, Arthur M. Dannenberg

Publikováno v: Vaccines, Vol 1, Iss 1, Pp 58-76 (2013)

Part I. Basic Principles. TB vaccines cannot prevent establishment of the infection. They can only prevent an early pulmonary tubercle from developing into clinical disease. A more effective new vaccine should optimize both cell-mediated immunity (CM

Externí odkaz: https://doaj.org/article/f7eed3e5d6c94d8797914ead67c19a67

Adipose Tissue Regulates Pulmonary Pathology during TB Infection

Autor: Jyothi F. Nagajyothi, Selvakumar Subbian, Christopher Vinnard, Usha Ganapathi, Janeesh Plakkal Ayyappan, Kezia Lizardo, David S. Perlin

Publikováno v: mBio, Vol 10, Iss 2, p e02771-18 (2019)
mBio
mBio, Vol 10, Iss 2 (2019)

Although the lungs are the port of entry and the predominant site of TB disease manifestation, we and others have demonstrated that M. tuberculosis also persists in adipose tissue of aerosol-infected animals and directly or indirectly alters adipose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0b1324971031ac5c546c542959b125
https://doi.org/10.1128/mbio.02771-18

Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing

Autor: Arthur M. Dannenberg, Bappaditya Dey

Publikováno v: Vaccines
Vaccines, Vol 1, Iss 1, Pp 58-76 (2013)

Part I. Basic Principles. TB vaccines cannot prevent establishment of the infection. They can only prevent an early pulmonary tubercle from developing into clinical disease. A more effective new vaccine should optimize both cell-mediated immunity (CM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76983ca66744f4866d44fe39a43a6fb1
https://doi.org/10.3390/vaccines1010058

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Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing.

Autor: Dannenberg AM; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. artdann@jhsph.edu.; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. artdann@jhsph.edu.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. artdann@jhsph.edu.; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA. artdann@jhsph.edu.; Center for Tuberculosis Research, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA. artdann@jhsph.edu., Dey B; Center for Tuberculosis Research, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA. bdey1@jhmi.edu.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. bdey1@jhmi.edu.

Publikováno v: Vaccines [Vaccines (Basel)] 2013 Jan 25; Vol. 1 (1), pp. 58-76. Date of Electronic Publication: 2013 Jan 25.