Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing

Autor: Bappaditya Dey, Arthur M. Dannenberg

Publikováno v: Vaccines, Vol 1, Iss 1, Pp 58-76 (2013)

Part I. Basic Principles. TB vaccines cannot prevent establishment of the infection. They can only prevent an early pulmonary tubercle from developing into clinical disease. A more effective new vaccine should optimize both cell-mediated immunity (CM

Externí odkaz: https://doaj.org/article/f7eed3e5d6c94d8797914ead67c19a67

Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing.

Autor: Dannenberg AM; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. artdann@jhsph.edu.; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. artdann@jhsph.edu.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. artdann@jhsph.edu.; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA. artdann@jhsph.edu.; Center for Tuberculosis Research, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA. artdann@jhsph.edu., Dey B; Center for Tuberculosis Research, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA. bdey1@jhmi.edu.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. bdey1@jhmi.edu.

Publikováno v: Vaccines [Vaccines (Basel)] 2013 Jan 25; Vol. 1 (1), pp. 58-76. Date of Electronic Publication: 2013 Jan 25.