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TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment

Autor: Wen Kang, Yiwen Wang, Jiaying Li, Weige Xie, Dan Zhao, Li Wu, Hongwei Wang, Sijing Xie

Publikováno v: Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2022)

Abstract Background Inflammatory microenvironment promotes odontoblastic differentiation in human dental pulp stem cells (hDPSCs), but the regulatory mechanisms remain unclear. In this study, we aimed to explore the role of TAS2R in odontoblastic dif

Externí odkaz: https://doaj.org/article/aed69f38d0e444998da6fe0f8341c5c5

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Akademický článek

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Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut

Autor: Emilio Canovai, Kathrin I. Liszt, Qiaoling Wang, Theo Thijs, Eveline Deloose, Matthias Lannoo, Jan Tack, Laurens J. Ceulemans, Inge Depoortere, Ricard Farré

Publikováno v: The FASEB Journal. 33:4907-4920

Chemosensory signaling in organs such as the mouth and gut contributes to the mechanisms that control metabolism. We investigated the chemosensory pathways that regulate secretion of the hunger hormone ghrelin in response to neurotransmitters, bitter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6f61e028f76a48f709437ee148c354
https://doi.org/10.1096/fj.201801661rr

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Next generation semiconductor based sequencing of bitter taste receptor genes in different pig populations and association analysis using a selective DNA pool-seq approach

Autor: Emilio Scotti, Valerio Joe Utzeri, Anisa Ribani, Stefania Dall'Olio, Paolo Trevisi, Paolo Bosi, Giuseppina Schiavo, Luca Fontanesi, Francesca Bertolini

Publikováno v: Animal Genetics. 48:97-102

Taste perception in animals affects feed intake and may influence production traits. In particular, bitter is sensed by receptors encoded by the family of TAS2R genes. In this research, using a DNA pool-seq approach coupled with next generation semic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fa7a1db27d1da34d938722a48b8ac2
https://doi.org/10.1111/age.12472

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Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14

Autor: Stefanie Nowak, Antonella Di Pizio, Anat Levit, Maik Behrens, Wolfgang Meyerhof, Masha Y. Niv

Publikováno v: Biochimica et biophysica acta. General subjects. 1862(10)

Background In humans, bitterness perception is mediated by ~25 bitter taste receptors present in the oral cavity. Among these receptors three, TAS2R10, TAS2R14 and TAS2R46, exhibit extraordinary wide agonist profiles and hence contribute disproportio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acebb79a2d8c070f77a07c4b152ef0c
https://pubmed.ncbi.nlm.nih.gov/30009876

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Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception

Autor: Leonardo Scaglioni, Giuseppe Mancuso, Angela Bassoli, Gigliola Borgonovo

Publikováno v: Molecules, Vol 20, Iss 10, Pp 18907-18922 (2015)
Molecules
Volume 20
Issue 10
Pages 18907-18922

Ruta graveolens (rue) is a spontaneous plant in the Mediterranean area with a strong aroma and a very intense bitter taste, used in gastronomy and in folk medicine. From the leaves, stems and fruits of rue, we isolated rutin, rutamarin, three furanoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd10361fb4695ac831989cba05784ec0
http://www.mdpi.com/1420-3049/20/10/18907

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Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells

Autor: Yoona Seo, Yoo Sun Kim, Yuri Kim, Tai Hyun Park, Kyung Eun Lee

Publikováno v: PLoS ONE
PLOS ONE(12): 5
PLoS ONE, Vol 12, Iss 5, p e0176851 (2017)

Neuroblastoma (NB) originates from immature neuronal cells and currently has a poor clinical outcome. NB cells possess cancer stem cells (CSCs) characteristics that facilitate the initiation of a tumor, as well as its metastasis. Human bitter taste r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b906cd7c3b7f1cd716c23364ddf8af44
http://europepmc.org/articles/PMC5414998

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Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle

Autor: Mamdoh Al-Ameri, Mikael Adner, Jesper Säfholm, Karl Swärd, Sven-Erik Dahlén, Martijn L. Manson, Ann-Charlotte Orre, Anna James, Per Bergman

Publikováno v: European Journal of Pharmacology. 740:302-311

Taste-sensing type 2 receptors (TAS2Rs) have been implicated in extraoral functions. Airway smooth muscle expresses TAS2Rs and is strongly relaxed by TAS2R agonists. We hypothesised that TAS2R agonists might affect vascular smooth muscle as well. Mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7037d000a3d3f0e353f2242f279bbbe
https://doi.org/10.1016/j.ejphar.2014.07.005

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Bitter taste receptors as targets for tocolytics in preterm labor therapy

Autor: Ping Lu, Tiffany A. Moore Simas, Jennifer C. Condon, Kaizhi Zheng, Karl D. Bellve, Ronghua ZhuGe, Ellen Delpapa, Fangxiong Shi, Ruitang Deng, Kevin E. Fogarty, Lawrence M. Lifshitz

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(9)

Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with few prevention and treatment options. Uterine contraction is a central feature of PTB, so gaining new insights into the mechanisms of this contraction and consequently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5fa38f73a8e65cd48b9f5e3989da692
https://pubmed.ncbi.nlm.nih.gov/28559440

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