Zobrazeno 1 - 10
of 78
pro vyhledávání: '"TAPBPR"'
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Background Major histocompatibility class I (MHC-I, human leukocyte antigen [HLA]-I in humans) molecules present small fragments of the proteome on the cell surface for immunosurveillance, which is pivotal to control infected and malignant cells. Imm
Externí odkaz:
https://doaj.org/article/ab62c45160514459b941413a277bb80b
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Peptide loading of MHC-I molecules plays a critical role in the T cell response to infections and tumors as well as to interactions with inhibitory receptors on natural killer (NK) cells. To facilitate and optimize peptide acquisition, vertebrates ha
Externí odkaz:
https://doaj.org/article/61680c52186a49d0a779f414c450671a
Autor:
David H. Margulies, Daniel K. Taylor, Jiansheng Jiang, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Kannan Natarajan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent on the identification of cell surface MHC molecules bearing peptides generated from either endogenous (MHC I) or exogenous (MHC II) dependent pathways. This
Externí odkaz:
https://doaj.org/article/4f2ff701293a4c0aac80f4c8856fbb79
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct 01. 115(40), E9353-E9361.
Externí odkaz:
https://www.jstor.org/stable/26531418
Akademický článek
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Akademický článek
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Autor:
Aflalo, Aure
Major histocompatibility complex class I (MHC-I) molecules play a crucial role in the immune response to infection and malignancy by presenting peptides to CD8+ T cells. Optimal peptide:MHC-I complexes are generated in the MHC-I antigen processing an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76db695d841ae9f1f66628435a5d4355
Autor:
Satti, Reem
Cytotoxic T-lymphocytes must recognise and respond in a highly antigen specific manner to tackle pathological threats, such as virus-infected or malignant cells. This is aided by cell surface glycoproteins called the major histocompatibility complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58f586b4d5738b3e74b6f3f97587b2fc
Autor:
F Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E Deane, Louise H Boyle
Publikováno v:
eLife, Vol 7 (2018)
Tapasin and TAPBPR are known to perform peptide editing on major histocompatibility complex class I (MHC I) molecules; however, the precise molecular mechanism(s) involved in this process remain largely enigmatic. Here, using immunopeptidomics in com
Externí odkaz:
https://doaj.org/article/d267f215987a4db2b173a8b9f985aef6
Autor:
Andreas Neerincx, Clemens Hermann, Robin Antrobus, Andy van Hateren, Huan Cao, Nico Trautwein, Stefan Stevanović, Tim Elliott, Janet E Deane, Louise H Boyle
Publikováno v:
eLife, Vol 6 (2017)
Recently, we revealed that TAPBPR is a peptide exchange catalyst that is important for optimal peptide selection by MHC class I molecules. Here, we asked whether any other co-factors associate with TAPBPR, which would explain its effect on peptide se
Externí odkaz:
https://doaj.org/article/c132d87a727842aba0f630db881afb89