Zobrazeno 1 - 10
of 26
pro vyhledávání: '"TAM, tumor associated macrophages"'
Autor:
Teruki Nii, Yasuhiko Tabata
Publikováno v:
Regenerative Therapy, Vol 18, Iss, Pp 516-522 (2021)
Regenerative Therapy
Regenerative Therapy
Introduction The objective of this study is to design a co-culture system of cancer cells and three-dimensional (3D) mesenchymal stem cells (MSC) aggregates for the in vitro evaluation of cancer invasion. Methods First, the MSC of an immunosuppressiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30478d0d874b865560a7aa85190b7a7e
http://hdl.handle.net/2433/277951
http://hdl.handle.net/2433/277951
Autor:
Masahiro Nishikawa, Ichiro Nakano, Afsana Islam, Yuji Watanabe, Daisuke Yamashita, Yasutsugu Takada, Satoshi Suehiro, Hideaki Watanabe, Junya Tanaka, Takeharu Kunieda, Yoshihiro Ohtsuka, Yutaro Sumida, Akihiro Umakoshi, Erika Hayase, Yusuke Nishi, Shota Ohsumi, Eika Usa, Saya Ozaki, Akihiro Inoue, Jun Kuwabara, Hajime Yano, Mohammed E. Choudhury
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 8, Pp 754-765 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Highlights • CLIC2 is highly expressed in benign, less invasive and less metastatic tumors. • Forced expression of CLIC2 prevents metastasis and invasion in animal tumor models. • CLIC2 is associated with decreased vascular permeability in tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a1857fc7fdf8e1121e51752c54bf4f
http://www.sciencedirect.com/science/article/pii/S1476558621000439
http://www.sciencedirect.com/science/article/pii/S1476558621000439
Publikováno v:
Advanced Drug Delivery Reviews
Graphical abstract
Even given recent advances in nanomedicine development of breast cancer treatment in recent years and promising results in pre-clinical models, cancer nanomedicines often fail at the clinical trial stage. Limitations of conven
Even given recent advances in nanomedicine development of breast cancer treatment in recent years and promising results in pre-clinical models, cancer nanomedicines often fail at the clinical trial stage. Limitations of conven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76811ce2af0ea0f7b3342230007c3c01
https://doi.org/10.1016/j.addr.2021.03.018
https://doi.org/10.1016/j.addr.2021.03.018
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping
Autor:
Katharine C. Lai, Michael D. Smith, Ian Nessler, Anna Kopp, Cornelius Cilliers, Thomas A. Keating, Adnan O. Abu-Yousif, Greg M. Thurber, Michelle L. Ganno, Eshita Khera
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303ee4292d185874883a1e4516940339
https://doi.org/10.1016/j.neo.2020.12.001
https://doi.org/10.1016/j.neo.2020.12.001
Autor:
Zhonggui He, Yixin Sun, Gang Wang, Linlin Cao, Yang Wang, Qikun Jiang, Jin Sun, Dongyang Zhao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1382-1396 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable impediment of local hypoxia in tumors. Moreover, PDT could further wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55dbc5e9669afc312da6e54f6cee2e96
https://doi.org/10.1016/j.apsb.2020.01.004
https://doi.org/10.1016/j.apsb.2020.01.004
Autor:
Zhigang Xu, Peng Xue, Tian Zhang, Yao Xiao, Xiaoxiao Shi, Zhi-Jun Sun, Shao-Chen Yang, Yuejun Kang, Xianbin Ma, Qi-Chao Yang, Shuo Wang, Gang Liu
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 451-466 (2022)
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 451-466 (2022)
The combination of chemotherapy and immunotherapy motivates a potent immune system by triggering immunogenic cell death (ICD), showing great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment (ITM). Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5211c83ba6d95f3418ded0361dee33da
https://pubmed.ncbi.nlm.nih.gov/35127398
https://pubmed.ncbi.nlm.nih.gov/35127398
Autor:
Izabela Siemińska, Kazimierz Węglarczyk, Marta Walczak, Agata Czerwińska, Radosław Pach, Mateusz Rubinkiewicz, Antoni Szczepanik, Maciej Siedlar, Jarek Baran
Publikováno v:
Translational Oncology
Translational Oncology, Vol 17, Iss, Pp 101346-(2022)
Translational Oncology, Vol 17, Iss, Pp 101346-(2022)
Highlights • Colorectal cancer patients present increased level of all MDSCs populations in peripheral blood. • Eosinophilic MDSCs can be distinguished among PMN-MDSCs in the blood of colorectal cancer patients. • In patients with colorectal ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3add3e023240e7ba91e9ad85e8df7ac5
https://doi.org/10.1016/j.tranon.2022.101346
https://doi.org/10.1016/j.tranon.2022.101346
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 8, Pp 775-788 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Epithelial-mesenchymal transition (EMT) is a major event during cancer progression and metastasis; however, the definitive role of EMT in remodeling tumor microenvironments (TMEs) is unclear. Tumor-associated macrophages (TAMs) are a major type of ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abe8c79daf46c4927f539730f04c04b
http://www.sciencedirect.com/science/article/pii/S1476558618301209
http://www.sciencedirect.com/science/article/pii/S1476558618301209
Autor:
Michel Salzet, Adriana Murgoci, Robert Day, Isabelle Fournier, Franck Rodet, Marie Duhamel, Maxence Wisztorski
Publikováno v:
EuPA Open Proteomics, Vol 11, Iss C, Pp 20-22 (2016)
EuPA Open Proteomics
EuPA Open Proteomics
Graphical abstract Schematic depicting how PC1/3 knockdown impacts macrophage activation based on the data presented.
Highlights • Proprotein convertase 1/3 knockdown or knockout macrophages present all the characteristic of activated pro-infl
Highlights • Proprotein convertase 1/3 knockdown or knockout macrophages present all the characteristic of activated pro-infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5511a1e46f49dc26553c4ec0f3daeb
http://www.sciencedirect.com/science/article/pii/S2212968516300204
http://www.sciencedirect.com/science/article/pii/S2212968516300204