Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation

Autor: Naoki Goshima, Yoshifumi Kawamura, Kentaro Semba, Kiyoshi Inageda, Shinya Watanabe, Gen Hiyama, Kosuke Ishikawa, Takushi Togashi, Jiro Fujimoto, Ai Wakamatsu, Motoki Takagi, Nobuhiko Takahashi, Arisa Higa, Hirotaka Hoshi

Publikováno v: Oncology Reports

Epidermal growth factor receptor (EGFR) overexpression and EGFR-mediated signaling pathway dysregulation have been observed in tumors from patients with various cancers, especially non-small cell lung cancer. Thus, several anti-EGFR drugs have been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56cd3cf26e21c69264f742f12307a6d
https://pubmed.ncbi.nlm.nih.gov/27840973

Automated Classification of Subcellular Localization of Proteins in HeLa Cells Using Fluorescent Microscopic Images

Autor: Reiko Minamikawa-Tachino, Noriko Kabuyama, Nobuo Nomura, Sumio Sugano, Toshiyuki Gotoh, Seiichiro Kagei, Takushi Togashi, Takahiro Tsunekawa

Publikováno v: Chem-Bio Informatics Journal. 4:27-37

We have developed a system to classify cellular forms of fusion proteins with an enhanced yellow fluorescent protein (EYFP) into subcellular compartments using images by a fluorescent microscope. The system aims at image classification to accommodate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a849f1afa073944c25b650cb08eada59
https://doi.org/10.1273/cbij.4.27

Identification of Canine .ALPHA.-Lactalbumin

Autor: Tsutomu Shimizu, Takushi Togashi, Susumu Tateyama, Ryoji Yamaguchi, Manabu Watanabe, Kazuyuki Uchida, Sumio Sugano

Publikováno v: Journal of Veterinary Medical Science. 62:1217-1219

The nucleotide sequence of canine alpha-lactalbumin cDNA from canine mammary tissue was determined by polymerase chain reaction with degenerate primers. A 742 base pairs nucleotide sequence cloned was similar to the size of mRNA in Northern blot anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f18826988e8760f6ef28f9f1c1f556
https://doi.org/10.1292/jvms.62.1217

A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55

Autor: Aya Nagai, Takayuki Doi, Yasutomo Kisu, Shigeaki Harayama, Takashi Takahashi, Kazuo Shin-ya, Tohru Natsume, Susumu Matukura, Takuji Nakashima, Motoki Takagi, Naoki Goshima, Nobuo Nomura, Takushi Togashi, Jun-ya Ueda, Hisayuki Komaki, Kozue Anzai

Publikováno v: The Journal of antibiotics. 60(7)

A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A(1) and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ed85676db75b96c58e8c56fa9e429a
https://pubmed.ncbi.nlm.nih.gov/17721005

Complete sequencing and characterization of 21,243 full-length human cDNAs

Autor: Yoko Yoshikawa, Hiroyo Kodaira, Akio Sugiyama, Kaoru Saito, Nobuo Nomura, Tsutomu Fujiwara, Naoko Katsuta, Shogo Moriya, Mitsuo Sekine, Tomoyasu Sugiyama, Hisatsugu Yuuki, Bunsei Kawakami, Sachiko Okamoto, Junichi Yamamoto, Koji Watanabe, Satoshi Aotsuka, Tadashi Satoh, Takami Komatsu, Yoshihiro Ohmori, Takao Iwayanagi, Akihiro Senoh, Machiko Tanikawa, Yasuko Ikema, Tomoko Hotuta, Takahide Yokoi, Naokazu Sasaki, Ryotaro Irie, Tatsunari Nishi, Sakae Togiya, Hirokazu Wakebe, Tadashi Senba, Yoshihiro Goto, Hiroshi Matsunawa, Yuko Terashima, Hiroshi Kondo, Katsue Yamada, Tetsuji Otsuki, Yasuhiko Masuho, Misato Morinaga, Hiroshi Mizoguchi, Makoto Takemoto, Asako Takahashi-Fujii, Kumiko Kamihara, Kiyomi Nakagawa, Saori Noguchi, Osamu Suzuki, Miho Arita, Susumu Hiraoka, Yuko Shirai, Kyoka Matsumura, Takeshi Watanabe, Kumi Abe, Hiromi Inagaki, Hiroyuki Sato, Manabu Watanabe, Ken Ninomiya, Yoshiyuki Chiba, Yusuke Nakamura, Shoko Itakura, Hiroko Momiyama, Emiko Kikkawa, Yuri Kawai, Yoshiko Nomura, Yoshie Nakajima, Hisashi Kikuchi, Manabu Kimata, Noriko Satoh, Yukiko Takahashi, Shinichi Ishida, Toshio Ota, Sachiko Takami, Tetsushi Yada, Atsushi Oshima, Reiko Hara, Keiko Shigeta, Takeshi Hikiji, Tetsuo Nishikawa, Hiroyuki Tanai, Satoshi Nakagawa, Ayako Kawabata, Kiyoshi Fujimori, Tadashi Ishibashi, Yoshiko Kaku, Yutaka Suzuki, Keiichi Nagai, Kouichi Ozaki, Takae Mizuno, Susumu Watanabe, Katsuhiro Kanda, Kazuha Takeuchi, Tomo-o Tanase, Katsuhiko Murakami, Masahide Sasaki, Makoto Yosida, Yasuhito Fukuzumi, Takehiko Hosoiri, Tomoko Itoh, Toshikazu Shibahara, Masaya Obayashi, Megumi Komiyama, Sumiyo Takiguchi, Koji Hayashi, Osamu Ohara, Hiroyuki Tashiro, Kazuomi Sato, Hiroto Hara, Makoto Yamazaki, Naoko Kobatake, Toshihiro Tanaka, Akiko Shiratori, Sanae Sano, Takuma Kawakami, Koji Okumura, Yoshifumi Fujimori, Masaaki Yamazaki, Kenji Nagahari, Sumio Sugano, Kouichi Kimura, Junko Kusano, Yukio Ono, Hiroaki Sudo, Takahiro Nagase, Fukuyo Komai, Yuko Isono, Haretsugu Hishigaki, Junko Mizushima-Sugano, Masako Wagatsuma, Fumio Shimizu, Hiroshi Makita, Yuka Fujii, Tatsuo Ichihara, Yuhi Omura, Tomohiro Yasuda, Kenta Nakai, Keiichi Kanehori, Shizuko Ishii, Takushi Togashi, Rie Okitani, Hiromichi Yamashita, Katsuji Murakawa, Akira Tanigami, Ai Wakamatsu, Namiko Shiohata, Kaoru Musashino, Ayako Kumagai, Toshihide Ono, Motoji Watanabe, Hiroko Hata, Yoshitaka Nakamura, Takako Furuya, Masaaki Oyama, Takao Isogai, Nobuyuki Imose, Masanori Sugawara, Makiko Takahashi, Riu Yamashita, Maasa Hirao

Publikováno v: Nature genetics. 36(1)

As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1423d4e4322c993cbee2219dafdff70a
https://pubmed.ncbi.nlm.nih.gov/14702039