Zobrazeno 1 - 10
of 277
pro vyhledávání: '"TAKESHI IWATA"'
Autor:
Kunihiro Azuma, Takafumi Suzuki, Kenta Kobayashi, Masako Nagahara, Hirotaka Imai, Akiko Suga, Takeshi Iwata, Tomoyasu Shiraya, Makoto Aihara, Takashi Ueta
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-12 (2024)
Abstract Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, particularly the late-stage of dry AMD known as geographic atrophy (GA), lacks effective treatment options. Genetic mouse models
Externí odkaz:
https://doaj.org/article/bd3beb598eb64000a5b3ab5cb93b582f
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract TRiC/CCT is a chaperonin complex required for the folding of cytoplasmic proteins. Although mutations in each subunit of TRiC/CCT are associated with various human neurodegenerative diseases, their impact in mammalian models has not yet been
Externí odkaz:
https://doaj.org/article/4329947dee664b71b14df5e4e27c9cea
Autor:
Yang Pan, Takeshi Iwata
Publikováno v:
Indian Journal of Ophthalmology, Vol 72, Iss Suppl 3, Pp S335-S344 (2024)
Normal tension glaucoma (NTG) is a complex optic neuropathy characterized by progressive retinal ganglion cell death and glaucomatous visual field loss, despite normal intraocular pressure (IOP). This condition poses a unique clinical challenge due t
Externí odkaz:
https://doaj.org/article/595765c1d3594626b2168ada851e19ff
Autor:
Akiko Suga, Kei Mizobuchi, Taiga Inooka, Kazutoshi Yoshitake, Naoko Minematsu, Kazushige Tsunoda, Kazuki Kuniyoshi, Yosuke Kawai, Yosuke Omae, Katsushi Tokunaga, Takaaki Hayashi, Shinji Ueno, Takeshi Iwata, Hatsue Ishibashi-Ueda, Tsutomu Tomita, Michio Noguchi, Ayako Takahashi, Yu-ichi Goto, Sumiko Yoshida, Kotaro Hattori, Ryo Matsumura, Aritoshi Iida, Yutaka Maruoka, Hiroyuki Gatanaga, Masaya Sugiyama, Satoshi Suzuki, Kengo Miyo, Yoichi Matsubara, Akihiro Umezawa, Kenichiro Hata, Tadashi Kaname, Kouichi Ozaki, Haruhiko Tokuda, Hiroshi Watanabe, Shumpei Niida, Eisei Noiri, Koji Kitajima, Reiko Miyahara, Hideyuki Shimanuki
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101843- (2024)
Purpose: Achromatopsia (ACHM) is an early-onset cone dysfunction caused by 5 genes with cone-specific functions (CNGA3, CNGB3, GNAT2, PDE6C, and PDE6H) and by ATF6, a transcription factor with ubiquitous expression. To improve the relatively low vari
Externí odkaz:
https://doaj.org/article/a0a40200ace245f49c062e5cf42c6c3b
Autor:
Ayaka Nakajima, Kazuki Kuniyoshi, Chiharu Iwahashi, Fukutaro Mano, Takaaki Hayashi, Hiroyuki Kondo, Kei Mizobuchi, Itsuka Matsushita, Akiko Suga, Kazutoshi Yoshitake, Tadashi Nakano, Takeshi Iwata, Chota Matsumoto, Shunji Kusaka
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionCongenital X-linked retinoschisis (XLRS) presents as macular retinoschisis/degeneration in almost all patients and as peripheral retinoschisis in half the patients. Although the optical coherence tomography (OCT) findings of macular retin
Externí odkaz:
https://doaj.org/article/5cc438d37d1e4519a8275761f4cfe3bc
Autor:
Yang Pan, Takeshi Iwata
Publikováno v:
Children, Vol 11, Iss 4, p 454 (2024)
Childhood glaucoma, a significant cause of global blindness, represents a heterogeneous group of disorders categorized into primary or secondary forms. Primary childhood glaucoma stands as the most prevalent subtype, comprising primary congenital gla
Externí odkaz:
https://doaj.org/article/e97166d1ff02476fbd6f7ef4a00786f8
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/26fa4b43b6844e1faa0911838d9a411e
Autor:
Fumihiko Mabuchi, Nakako Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuki Hashimoto, Kota Sato, Yukihiro Shiga, Toru Nakazawa, Masato Akiyama, Kazuhide Kawase, Mineo Ozaki, Makoto Araie
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Primary open-angle glaucoma (POAG) is characterized by a progressive optic neuropathy with visual field loss. To investigate the genetic variants associated with visual field loss in POAG, Japanese POAG patients (n = 426) and control subject
Externí odkaz:
https://doaj.org/article/d6698042b9444061bd8b926151ae6e4d
Autor:
Kazuki Yamazawa, Kenji Shimizu, Hirofumi Ohashi, Hidenori Haruna, Satomi Inoue, Haruka Murakami, Tatsuo Matsunaga, Takeshi Iwata, Kazushige Tsunoda, Kaoru Fujinami
Publikováno v:
Human Genome Variation, Vol 8, Iss 1, Pp 1-4 (2021)
Abstract 2p15p16.1 microdeletion syndrome is a recently recognized congenital disorder characterized by developmental delay and dysmorphic features. RP2-associated retinal disorder (RP2-RD) is an X-linked inherited retinal disease with a childhood on
Externí odkaz:
https://doaj.org/article/1a70d1b9a71d4787b13f5b984bedb2c3
Autor:
Yang Pan, Akiko Suga, Itaru Kimura, Chojiro Kimura, Yuriko Minegishi, Mao Nakayama, Kazutoshi Yoshitake, Daisuke Iejima, Naoko Minematsu, Megumi Yamamoto, Fumihiko Mabuchi, Mitsuko Takamoto, Yukihiro Shiga, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Toru Nakazawa, Takeshi Iwata
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Normal-tension glaucoma (NTG) is a heterogeneous disease characterized by retinal ganglion cell (RGC) death leading to cupping of the optic nerve head and visual field loss at normal intraocular pressure (IOP). The pathogenesis of NTG remains unclear
Externí odkaz:
https://doaj.org/article/fa55a64544c84ae98af99969aabc1b8b