Zobrazeno 1 - 10
of 68
pro vyhledávání: '"TAKASHI YOSHIZUMI"'
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Supplementary Figure 4 from Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fbd4990659e663b7dccb7e40258433
https://doi.org/10.1158/1535-7163.22486068
https://doi.org/10.1158/1535-7163.22486068
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Wee1 is a tyrosine kinase that phosphorylates and inactivates CDC2 and is involved in G2 checkpoint signaling. Because p53 is a key regulator in the G1 checkpoint, p53-deficient tumors rely only on the G2 checkpoint after DNA damage. Hence, such tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6083f36a3d2a471a2a2ebf46afa829f9
https://doi.org/10.1158/1535-7163.c.6532227.v1
https://doi.org/10.1158/1535-7163.c.6532227.v1
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Supplementary Figure 3 from Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f3febe721d3504881be88ebdf1890e
https://doi.org/10.1158/1535-7163.22486071
https://doi.org/10.1158/1535-7163.22486071
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Supplementary Figure 1 from Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fe199219c306c270d9d95973603ade
https://doi.org/10.1158/1535-7163.22486077
https://doi.org/10.1158/1535-7163.22486077
Autor:
Hidehito Kotani, Shinji Mizuarai, Takashi Yoshizumi, Takeshi Sagara, Toshihiro Sakamoto, Hiroharu Arakawa, Takumi Sakai, Jian Jiang, Tadahiro Nambu, Hiroko Oki, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Hiraku Itadani, Kazunori Yamanaka, Junko Ohtani, Naoki Kaneko, Toshifumi Kimura, Makiko Kobayashi, Toshihide Nishibata, Tsuyoshi Arai, Megumu Okada, Yoshikazu Iwasawa, Hiroshi Hirai
Supplementary Figure 2 from Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c548c563bdee1d537f11e9305fc523c6
https://doi.org/10.1158/1535-7163.22486074.v1
https://doi.org/10.1158/1535-7163.22486074.v1
Publikováno v:
JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY. 23:357-361
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acfc8437ff1b3389375f4b65b3bc8236
https://doi.org/10.5106/jjshns.23.357
https://doi.org/10.5106/jjshns.23.357
Publikováno v:
JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY. 23:363-368
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dce71e83d2f315da7b4931bfc1ab775
https://doi.org/10.5106/jjshns.23.363
https://doi.org/10.5106/jjshns.23.363
Autor:
Tetsuo Takimura, Ikuko Takahashi, Hirokazu Ohsawa, Takashi Yoshizumi, Hidehito Kotani, Kenji Kamata, Yoshikazu Iwasawa, Kazuhiro Fukasawa, Hideya Komatani
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 66:577-583
Protein kinase C (PKC) plays an essential role in a wide range of cellular functions. Although crystal structures of the PKC-theta, PKC-iota and PKC-betaII kinase domains have previously been determined in complexes with small-molecule inhibitors, no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f772db4be874eee86662acb819255d
https://doi.org/10.1107/s0907444910005639
https://doi.org/10.1107/s0907444910005639
Autor:
Madoka Furukawa, Ken-ichi Nibu, Takashi Fujii, Ryuichi Hayashi, Masashi Sugasawa, Morimasa Kitamura, Masato Fujii, Kazuyoshi Kawabata, Masahisa Saikawa, Nobuya Monden, Masao Asai, Hiroya Ojiri, Tetsuo Onitsuka, Yusuhisa Hasegawa, Hiroaki Nakatani, Takashi Yoshizumi, Watarau Nishijima, Yoshinobu Tomita, Masakazu Miyazaki, Kazunori Matsuura, Naoyuki Kohno, Katsuyuki Doi, Seiji Kishimoto, Tadasi Nakashima, Takahiro Asakage
Publikováno v:
Toukeibu Gan. 36:82-88
厚生労働省科学研究費補助金「頭頸部がんのリンパ節転移に対する標準的治療法の確立に関する研究」（斉川班）で作成した頸部郭清術後機能評価法を用いて，本研究班において見学調
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cec50b53b9f9bac82633eac50d3d9efe
https://doi.org/10.5981/jjhnc.36.82
https://doi.org/10.5981/jjhnc.36.82
Autor:
Takashi Yoshizumi, Kazunori Yamanaka, Makiko Kobayashi, Tsuyoshi Arai, Hiraku Itadani, Yoshikazu Iwasawa, Hiroshi Hirai, Naoki Kaneko, Toshihide Nishibata, Megumu Okada, Shinji Mizuarai, Junko Ohtani, Takumi Sakai, Takeshi Sagara, Tadahiro Nambu, Toshihiro Sakamoto, Kazuhiro Fukasawa, Ikuko Takahashi-Suzuki, Jian Jiang, Toshifumi Kimura, Hiroharu Arakawa, Hiroko Oki, Hidehito Kotani
Publikováno v:
Molecular Cancer Therapeutics. 8:2992-3000
Wee1 is a tyrosine kinase that phosphorylates and inactivates CDC2 and is involved in G2 checkpoint signaling. Because p53 is a key regulator in the G1 checkpoint, p53-deficient tumors rely only on the G2 checkpoint after DNA damage. Hence, such tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58dfc37efdc35cf44dfb7bb56d20b73
https://doi.org/10.1158/1535-7163.mct-09-0463
https://doi.org/10.1158/1535-7163.mct-09-0463