Zobrazeno 1 - 10
of 403
pro vyhledávání: '"TAKANOBU OTSUKA"'
Autor:
Gen Kuroyanagi, Haruhiko Tokuda, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Woo Kim, Tomoyuki Hioki, Junko Tachi, Rie Matsushima-Nishiwaki, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Heat shock protein (HSP) 90 functions as a molecular chaperone and is constitutively expressed and induced in response to stress in many cell types. We have previously demonstrated that transforming growth factor-β (TGF-β), the
Externí odkaz:
https://doaj.org/article/d7dab7483c244fb296d6568b40a34bef
Autor:
Gen Kuroyanagi, Go Sakai, Takanobu Otsuka, Naohiro Yamamoto, Kazuhiko Fujita, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-8 (2021)
Abstract Background Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated that prostaglandin F2α (PGF2α), a potent bone remodeling factor, induces the
Externí odkaz:
https://doaj.org/article/aa50c6de43b44762b74f761572db8ea6
Autor:
Shiro Saito, Hisaki Aiba, Satoshi Yamada, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takanobu Otsuka, Hideki Murakami
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-6 (2020)
Abstract Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with thi
Externí odkaz:
https://doaj.org/article/0596c91250484339a18bca292edc5b43
Autor:
Gen Kuroyanagi, Junko Tachi, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Daiki Nakashima, Woo Kim, Kumiko Tanabe, Rie Matsushima-Nishiwaki, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa, Haruhiko Tokuda
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Interleukin-6 (IL-6) is a pro-inflammatory and bone-resorptive cytokine that also regulates bone formation. We previously showed that prostaglandin E1 (PGE1) induces the synthesis of IL-6 by activating p44/p42 mitogen-activated protein kinase (MAPK),
Externí odkaz:
https://doaj.org/article/87a922416b5041e3a5590c0733185f28
Autor:
Shinji Miwa, Michi Kamei, Satoru Yoshida, Satoshi Yamada, Hisaki Aiba, Hiroyuki Tsuchiya, Takanobu Otsuka
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-6 (2019)
Abstract Background Limited evidence is available regarding the dissemination of tumor tissues due to compression during massage therapy, a routine procedure in patients with various symptoms in Asian countries. Case presentation A 12-year-old male p
Externí odkaz:
https://doaj.org/article/0a912a6611f64c7e8b5db2761ceb03ed
Autor:
Jun Mizutani, Nozomu Inoue, Yoshihisa Otsuka, Aiharu Furuya, Alejandro A. Espinoza Orias, Takanobu Otsuka
Publikováno v:
Neurospine, Vol 16, Iss 2, Pp 347-353 (2019)
Objective This study was conducted to clarify the validity of the short posterior arch screw (S-PAS). The S-PAS is inserted only in the pedicle-analogue portion of the posterior arch. The S-PAS screw length is almost half that conventional C1 lateral
Externí odkaz:
https://doaj.org/article/11c54115ba9949bda9b339b9b4a38172
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 350 (2022)
Cell transplantation therapy is a promising strategy for spinal cord injury (SCI) repair. Despite advancements in the development of therapeutic strategies in acute and subacute SCI, much less is known about effective strategies for chronic SCI. In p
Externí odkaz:
https://doaj.org/article/ba573196c9eb4ba091554eb3ad45b7b6
Autor:
Woo Kim, Kumiko Tanabe, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Junko Tachi, Tomoyuki Hioki, Daiki Nakashima, Shinobu Yamaguchi, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Hiroki Iida
Publikováno v:
Heliyon, Vol 6, Iss 8, Pp e04779- (2020)
Osteoprotegerin (OPG) synthesized by osteoblasts is currently considered a crucial regulator to suppress the formation and function of osteoclasts. We previously showed that the synthesis of OPG is stimulated by prostaglandin F2α (PGF2α) in the inv
Externí odkaz:
https://doaj.org/article/87d544ee505e40fa9018607e7ff1e5e8
Autor:
Hisaki Aiba, Masaaki Kobayashi, Yuko Waguri-Nagaya, Hideyuki Goto, Jun Mizutani, Satoshi Yamada, Hideki Okamoto, Masahiro Nozaki, Hiroto Mitsui, Shinji Miwa, Makoto Kobayashi, Kojiro Endo, Shiro Saito, Taeko Goto, Takanobu Otsuka
Publikováno v:
BMC Musculoskeletal Disorders, Vol 19, Iss 1, Pp 1-7 (2018)
Abstract Background Although aneurysmal bone cysts (ABCs) are benign tumours, they have the potential to be locally aggressive. Various treatment approaches, such as en bloc resection, open curettage, radiotherapy, sclerotherapy, and embolization hav
Externí odkaz:
https://doaj.org/article/cf1600726ef74a9f99ad99654f4904cd
Autor:
Hisaki Aiba, Masaaki Kobayashi, Yuko Waguri-Nagaya, Hideyuki Goto, Jun Mizutani, Satoshi Yamada, Hideki Okamoto, Masahiro Nozaki, Hiroto Mitsui, Shinji Miwa, Makoto Kobayashi, Kojiro Endo, Shiro Saito, Taeko Goto, Takanobu Otsuka
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 13, Iss 1, Pp 1-9 (2018)
Abstract Background Endoscopic curettage is considered applicable for the treatment of simple bone cysts with the expectation that it might be less invasive than open curettage. In this study, we investigated the efficacy of endoscopic curettage for
Externí odkaz:
https://doaj.org/article/476098c64b624e3d82d5c73e665ca926