Zobrazeno 1 - 10
of 166
pro vyhledávání: '"TAKAMI TOMIYAMA"'
Autor:
Akiko Amano, Nobuo Sanjo, Wataru Araki, Yasutaka Anraku, Makoto Nakakido, Etsuro Matsubara, Takami Tomiyama, Tetsuya Nagata, Kouhei Tsumoto, Kazunori Kataoka, Takanori Yokota
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Although a large amount of evidence has revealed that amyloid β (Aβ), especially Aβ oligomers, protofibrils, and pyroglutamated Aβs, participate primarily in the pathophysiological processes of Alzheimer’s disease, most clin
Externí odkaz:
https://doaj.org/article/8b45c3e51a3b4087b398375c02604d43
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Amyloidogenic protein oligomers are thought to play an important role in the pathogenesis of neurodegenerative dementia, including Alzheimer’s disease, frontotemporal dementia, and dementia with Lewy bodies. Previously we demonstrated that oral or
Externí odkaz:
https://doaj.org/article/953e476fb70a43568b647c601a40e8dc
Autor:
Yukari Hatanaka, Tomohiro Umeda, Keiko Shigemori, Toshihide Takeuchi, Yoshitaka Nagai, Takami Tomiyama
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1080 (2022)
The non-coding GGGGCC hexanucleotide repeat expansion (HRE) in C9orf72 gene is a dominant cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This intronic mutation elicits the formation of nuclear and cytoplasmic inclusio
Externí odkaz:
https://doaj.org/article/9d6ac0bc4b2b458a85fd9d819abfed78
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 297 (2022)
The cell-to-cell transmission of tau aggregates is considered a mechanism underlying the intracerebral spreading of tau pathology in Alzheimer’s disease (AD) and other tauopathies. Recent studies suggest that tau oligomers, rather than fibrils, par
Externí odkaz:
https://doaj.org/article/fe9a2ec6b52d4d7b8e083cd374b77a20
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra, Vol 8, Iss 1, Pp 77-84 (2018)
Background: Weight loss accelerates cognitive decline and increases mortality in patients with dementia. While acetylcholinesterase (AChE) inhibitors are known to cause appetite loss, we sometimes encounter patients in whom switching from donepezil (
Externí odkaz:
https://doaj.org/article/8c27a2ee4e704f4c913c43ff23d17f3c
Autor:
Tomohiro Umeda, Tetsuya Kimura, Kayo Yoshida, Keizo Takao, Yuki Fujita, Shogo Matsuyama, Ayumi Sakai, Minato Yamashita, Yuki Yamashita, Kiyouhisa Ohnishi, Mamiko Suzuki, Hiroshi Takuma, Tsuyoshi Miyakawa, Akihiko Takashima, Takashi Morita, Hiroshi Mori, Takami Tomiyama
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-15 (2017)
Abstract The E693Δ (Osaka) mutation in APP is linked to familial Alzheimer’s disease. While this mutation accelerates amyloid β (Aβ) oligomerization, only patient homozygotes suffer from dementia, implying that this mutation is recessive and cau
Externí odkaz:
https://doaj.org/article/22482dc3cde0468b9c8450aa2fae8a6a
Autor:
Juan Pablo Palavicini, Chunyan Wang, Linyuan Chen, Kristen Hosang, Jianing Wang, Takami Tomiyama, Hiroshi Mori, Xianlin Han
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-17 (2017)
Abstract Alzheimer’s disease (AD) is histopathologically characterized by the build-up of fibrillar amyloid beta (Aβ) in the form of amyloid plaques and the development of intraneuronal neurofibrillary tangles consisting of aggregated hyperphospho
Externí odkaz:
https://doaj.org/article/1efde33df074468299e8bb8bb06034a0
Autor:
Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Takami Tomiyama, Ikuo Tooyama
Publikováno v:
Molecules, Vol 26, Iss 5, p 1362 (2021)
Recent evidence suggests that the formation of soluble amyloid β (Aβ) aggregates with high toxicity, such as oligomers and protofibrils, is a key event that causes Alzheimer’s disease (AD). However, understanding the pathophysiological role of su
Externí odkaz:
https://doaj.org/article/a17d4f34fbd84a529a517d135c071ed5
Autor:
Yoichi Ohshima, Katsutoshi Taguchi, Ikuko Mizuta, Masaki Tanaka, Takami Tomiyama, Fuyuki Kametani, Chihiro Yabe-Nishimura, Toshiki Mizuno, Takahiko Tokuda
Publikováno v:
Heliyon, Vol 4, Iss 1 (2018)
Soluble oligomers of amyloid-β (Aβ) peptides (AβOs) contribute to neurotoxicity in Alzheimer’s disease (AD). However, it currently remains unknown whether an increase in AβOs is the common phenotype in cellular and animal models. Furthermore, i
Externí odkaz:
https://doaj.org/article/488c17ac603945d0acd4349798871601
Autor:
Takashi Kasai, Masaki Kondo, Ryotaro Ishii, Akihiro Tanaka, Suzuka Ataka, Hiroyuki Shimada, Takami Tomiyama, Hiroshi Mori, Mark Taylor, David Allsop, Masanori Nakagawa, Toshiki Mizuno, Takahiko Tokuda
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174630 (2017)
Intravenous immunoglobulin (IVIg) has been a candidate as a potential anti-amyloid immunotherapy for Alzheimer disease (AD) because it contains anti-amyloid β (Aβ) antibodies. Although several studies with IVIg in AD have been published, changing l
Externí odkaz:
https://doaj.org/article/a99a57f1e6dd4c0386a48565f6b20d4b