Zobrazeno 1 - 10
of 170
pro vyhledávání: '"TAKAKI HIWASA"'
Autor:
Toshiki Namiki, Minoru Takemoto, Aiko Hayashi, Hiroki Yamagata, Takahiro Ishikawa, Koutaro Yokote, Shu-Yang Li, Masaaki Kubota, Bo-Shi Zhang, Yoichi Yoshida, Tomoo Matsutani, Seiichiro Mine, Toshio Machida, Yoshio Kobayashi, Jiro Terada, Akira Naito, Koichiro Tatsumi, Hirotaka Takizawa, Rika Nakamura, Hideyuki Kuroda, Yasuo Iwadate, Takaki Hiwasa
Publikováno v:
BMC Endocrine Disorders, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Autoantibodies develop in autoimmune diseases, cancer, diabetes mellitus (DM), and atherosclerosis-related diseases. However, autoantibody biomarkers have not been successfully examined for diagnosis and therapy. Methods Serologic
Externí odkaz:
https://doaj.org/article/cdd10618ca81486f9f8b501d8fd1cd27
Autor:
Takahiro Arasawa, Takaki Hiwasa, Akiko Kagaya, Tetsuro Maruyama, Masaya Uesato, Masayuki Kano, Sohei Kobayashi, Hirotaka Takizawa, Katsuro Iwase, Fumio Nomura, Kazuyuki Matsushita, Hisahiro Matsubara
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Colorectal cancer (CRC) is the third most prevalent cancer in the world, yet the sensitivity and specificity of biomarkers for CRC diagnosis are insufficient. In the present study, we performed a protein microarray screening method to identi
Externí odkaz:
https://doaj.org/article/8200253a21d048bd818f01139aeea83f
Autor:
Hiroki Yamagata, Aiko Hayashi, Yoich Yoshida, Masaya Koshizaka, Shunichiro Onishi, Tomohiko Yoshida, Takaki Hiwasa, Minoru Takemoto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract In addition to pathogenic autoantibodies, polyclonal autoantibodies with unknown physiological roles and pathogenicity are produced in the body. Moreover, serum antibodies against the proprotein convertase subtilisin/kexin type 9 (PCSK9) pro
Externí odkaz:
https://doaj.org/article/8ba523a3389043c196e170f0f89444b9
Autor:
Natsuko Sasajima, Makoto Sumazaki, Yoko Oshima, Masaaki Ito, Satoshi Yajima, Hirotaka Takizawa, Hao Wang, Shu-Yang Li, Bo-Shi Zhang, Yoichi Yoshida, Takaki Hiwasa, Hideaki Shimada
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5470 (2024)
The relationship between energy production and cancer is attracting attention. This study aimed to investigate the clinicopathological significance of fumarate hydratase (FH), a tricarboxylic acid cycle enzyme, in gastric cancer using autoantibodies
Externí odkaz:
https://doaj.org/article/15e3ef8646c14115957614a800df2bc7
Autor:
Bo-Shi Zhang, Xiao-Meng Zhang, Masaaki Ito, Satoshi Yajima, Kimihiko Yoshida, Mikiko Ohno, Eiichiro Nishi, Hao Wang, Shu-Yang Li, Masaaki Kubota, Yoichi Yoshida, Tomoo Matsutani, Seiichiro Mine, Toshio Machida, Minoru Takemoto, Hiroki Yamagata, Aiko Hayashi, Koutaro Yokote, Yoshio Kobayashi, Hirotaka Takizawa, Hideyuki Kuroda, Hideaki Shimada, Yasuo Iwadate, Takaki Hiwasa
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4935 (2024)
Inflammation is closely associated with cerebrovascular diseases, cardiovascular diseases, diabetes, and cancers, and it is accompanied by the development of autoantibodies in the early stage of inflammation-related diseases. Hence, it is meaningful
Externí odkaz:
https://doaj.org/article/f7866b51e45c41ad925933e0259f77cb
Autor:
Go Tomiyoshi, Rika Nakamura, Natsuko Shinmen, Yoichi Yoshida, Seiichiro Mine, Toshio Machida, Katsuro Iwase, Yasuo Iwadate, Takaki Hiwasa, Hideyuki Kuroda
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
We previously identified growth arrest and DNA-damage-inducible gene 34 (GADD34) as a marker of ischemic stroke. In the present study, serum levels of anti-GADD34 antibodies were found to be significantly higher in patients with acute ischemic stroke
Externí odkaz:
https://doaj.org/article/b359c865246f4dafb4b9b55a2ac6bc5b
Autor:
Shu-Yang Li, Yoichi Yoshida, Masaaki Kubota, Bo-Shi Zhang, Tomoo Matsutani, Masaaki Ito, Satoshi Yajima, Kimihiko Yoshida, Seiichiro Mine, Toshio Machida, Aiko Hayashi, Minoru Takemoto, Koutaro Yokote, Mikiko Ohno, Eiichiro Nishi, Kenichiro Kitamura, Ikuo Kamitsukasa, Hirotaka Takizawa, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Katsuro Iwase, Hideaki Shimada, Yasuo Iwadate, Takaki Hiwasa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionAutoantibodies against inflammatory cytokines may be used for the prevention of atherosclerosis. Preclinical studies consider colony-stimulating factor 2 (CSF2) as an essential cytokine with a causal relationship to atherosclerosis and ca
Externí odkaz:
https://doaj.org/article/35788a9a94f345eab5c3423a98b90c80
Autor:
Masaaki Kubota, Yoichi Yoshida, Eiichi Kobayashi, Tomoo Matsutani, Shu-Yang Li, Bo-Shi Zhang, Seiichiro Mine, Toshio Machida, Hirotaka Takizawa, Takaki Hiwasa, Yasuo Iwadate
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The presence of disease-specific antigens and autoantibodies in the sera of patients with atherosclerosis-related diseases has been widely reported and is considered to result from inflammation of the arterial wall and the involvement of imm
Externí odkaz:
https://doaj.org/article/bd1aa44625364c7b85c95ab9f37de29f
Autor:
Hao Wang, Hao Lu, Xiao-Meng Zhang, Ken-ichiro Goto, Eiichi Kobayashi, Yoichi Yoshida, Akihiko Adachi, Tomoo Matsutani, Yasuo Iwadate, Seiichiro Mine, Toshio Machida, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Ikuo Kamitsukasa, Takeshi Wada, Akiyo Aotsuka, Kazuo Sugimoto, Hirotaka Takizawa, Koichi Kashiwado, Hideo Shin, Go Tomiyoshi, Rika Nakamura, Natsuko Shinmen, Hideyuki Kuroda, Anding Xu, Takaki Hiwasa
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Ischemic stroke, including transient ischemic attack (TIA) and acute-phase cerebral infarction (aCI), is a serious health problem in the aging society. Thus, this study aimed to identify TIA and aCI biomarkers. Methods In 19 patie
Externí odkaz:
https://doaj.org/article/d99105e8d52042e59bc979519ff2ac73
Autor:
Takaki Hiwasa, Hao Wang, Ken-ichiro Goto, Seiichiro Mine, Toshio Machida, Eiichi Kobayashi, Yoichi Yoshida, Akihiko Adachi, Tomoo Matsutani, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Mitoshi Kunimatsu, Ikuo Kamitsukasa, Masahiro Mori, Kazuo Sugimoto, Akiyuki Uzawa, Mayumi Muto, Satoshi Kuwabara, Yoshio Kobayashi, Mikiko Ohno, Eiichiro Nishi, Akiko Hattori, Masashi Yamamoto, Yoshiro Maezawa, Kazuki Kobayashi, Ryoichi Ishibashi, Minoru Takemoto, Koutaro Yokote, Hirotaka Takizawa, Takashi Kishimoto, Kazuyuki Matsushita, Sohei Kobayashi, Fumio Nomura, Takahiro Arasawa, Akiko Kagaya, Tetsuro Maruyama, Hisahiro Matsubara, Minako Tomiita, Shinsaku Hamanaka, Yushi Imai, Tomoo Nakagawa, Naoya Kato, Jiro Terada, Takuma Matsumura, Yusuke Katsumata, Akira Naito, Nobuhiro Tanabe, Seiichiro Sakao, Koichiro Tatsumi, Masaaki Ito, Fumiaki Shiratori, Makoto Sumazaki, Satoshi Yajima, Hideaki Shimada, Mikako Shirouzu, Shigeyuki Yokoyama, Takashi Kudo, Hirofumi Doi, Katsuro Iwase, Hiromi Ashino, Shu-Yang Li, Masaaki Kubota, Go Tomiyoshi, Natsuko Shinmen, Rika Nakamura, Hideyuki Kuroda, Yasuo Iwadate
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-25 (2021)
Abstract Background Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS is a serious cause of mortality and disability. Early diagnosis of atherosclerosis, which is the major cause of AIS, allows therapeutic intervention b
Externí odkaz:
https://doaj.org/article/9a2b8131969246478354b0215266296a