Zobrazeno 1 - 10
of 279
pro vyhledávání: '"TADAATSU IMAIZUMI"'
Autor:
Mayuki Tachizaki, Sho Sakamoto, Yuri Kobori, Yoshiya Asano, Shogo Kawaguchi, Kazuhiko Seya, Hiroshi Tanaka, Eiji Morita, Tadaatsu Imaizumi
Publikováno v:
FEBS Open Bio, Vol 14, Iss 8, Pp 1303-1319 (2024)
Viral infections in tubular epithelial cells lead to the production of inflammatory cytokines by innate immunity, causing tubulointerstitial nephritis. TLR3 recognizes viral infections and acts via the activation of interferon (IFN)/IFN‐stimulated
Externí odkaz:
https://doaj.org/article/494995e0ba894709b891986b08201d5a
Autor:
Takao Karasawa, Riko Sato, Tadaatsu Imaizumi, Masashi Fujita, Tomomi Aizawa, Koji Tsugawa, Deborah Mattinzoli, Shogo Kawaguchi, Kazuhiko Seya, Kiminori Terui, Kensuke Joh, Hiroshi Tanaka
Publikováno v:
Renal Failure, Vol 45, Iss 1 (2023)
AbstractBackground In addition to regulating the antiviral response, increased expression of Toll-like receptor 3 (TLR3) in resident renal cells plays a role in developing some forms of glomerulonephritis. TLR3 activation leads to type I interferon (
Externí odkaz:
https://doaj.org/article/33b7c3052e544918bd20c00865a6942d
Autor:
Takao Karasawa, Riko Sato, Tadaatsu Imaizumi, Shun Hashimoto, Masashi Fujita, Tomomi Aizawa, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Kiminori Terui, Hiroshi Tanaka
Publikováno v:
Renal Failure, Vol 44, Iss 1, Pp 137-145 (2022)
Background Sustained type I interferon (IFN) activation via Toll-like receptor (TLR) 3, 7 and 9 signaling has been reported to play a pivotal role in the development of lupus nephritis (LN). Although type I IFN activation has been shown to induce int
Externí odkaz:
https://doaj.org/article/8be58796b43b485d9d516880d6fab906
Autor:
Liu Xu, Zaiqiang Yu, Yoshinori Uekusa, Shogo Kawaguchi, Haruhisa Kikuchi, Kazuyuki Daitoku, Masahito Minakawa, Shigeru Motomura, Ken-Ichi Furukawa, Yoshiteru Oshima, Kazuhiko Seya, Tadaatsu Imaizumi
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 3, Pp 147-157 (2022)
Drug development for regulating the innate immune system is important for the prevention and treatment of autoinflammatory and autoimmune diseases. In this context, we investigated the effect of resveratrol derivatives on the inflammatory reactions i
Externí odkaz:
https://doaj.org/article/449ae64accd9433da99b02a2ffd174cd
Autor:
Liu Xu, Zaiqiang Yu, Yoshinori Uekusa, Shogo Kawaguchi, Haruhisa Kikuchi, Kazuyuki Daitoku, Masahito Minakawa, Shigeru Motomura, Ken-Ichi Furukawa, Yoshiteru Oshima, Kazuhiko Seya, Tadaatsu Imaizumi
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 1, Pp 63-64 (2023)
Externí odkaz:
https://doaj.org/article/d99d7f955bd049888b5a7d03a9abd3c9
Autor:
Hidenori Umetsu, Shojiro Watanabe, Tadaatsu Imaizumi, Tomomi Aizawa, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Hiroshi Tanaka
Publikováno v:
Kidney & Blood Pressure Research, Vol 46, Iss 2, Pp 207-218 (2021)
Background: Although toll-like receptor 3 (TLR3) signaling is involved in the development of certain chronic kidney diseases, the specific molecular mechanisms underlying inflammatory reactions via activation of TLR3 signaling in human podocytes rema
Externí odkaz:
https://doaj.org/article/ad09e26b2fea49c4819ed069b004b2c2
Autor:
Xu Liu, Zaiqiang Yu, Kazuyuki Daitoku, Ikuo Fukuda, Shigeru Motomura, Tomoh Matsumiya, Tadaatsu Imaizumi, Ken-Ichi Furukawa, Kazuhiko Seya
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 2, Pp 213-221 (2021)
Since aortic valve stenosis (AVS) is the most frequent and serious valvular heart disease in the elderly, and is accompanied by irreversible valve calcification, medicinal prevention of AVS is important. Although we recently demonstrated that human a
Externí odkaz:
https://doaj.org/article/a634f22a42784062a05da75f18d049a3
Autor:
Riko Sato, Tadaatsu Imaizumi, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Hiroshi Tanaka
Publikováno v:
Renal Failure, Vol 43, Iss 1, Pp 643-650 (2021)
Objective Although anti-malarial agents, chloroquine (CQ) and hydroxychloroquine (HCQ) are currently used for the treatment of systemic lupus erythematosus, their efficacy for lupus nephritis (LN) remains unclear. Given that upregulation of glomerula
Externí odkaz:
https://doaj.org/article/dd186af8fa074bd6aaf1b9d29f6fabd3
Autor:
Tadaatsu Imaizumi, Shun Hashimoto, Riko Sato, Hidenori Umetsu, Tomomi Aizawa, Shojiro Watanabe, Shogo Kawaguchi, Tomoh Matsumiya, Kazuhiko Seya, Jiangli Ding, Hiroshi Tanaka
Publikováno v:
Kidney & Blood Pressure Research, Pp 1-12 (2020)
Introduction: Various viruses including a novel coronavirus (SARS-CoV-2) can infect the kidney. When viruses invade the glomeruli from the bloodstream, glomerular endothelial cells (GECs) initiate the innate immune reactions. We investigated the expr
Externí odkaz:
https://doaj.org/article/1c95c3ab84dd46bb978657e048e8373d
Autor:
Qiang Liu, Tadaatsu Imaizumi, Tomomi Aizawa, Koji Hirono, Shogo Kawaguchi, Shojiro Watanabe, Koji Tsugawa, Tomoh Matsumiya, Kazuhiko Seya, Hidemi Yoshida, Hiroshi Tanaka
Publikováno v:
Kidney & Blood Pressure Research, Vol 44, Iss 1, Pp 62-71 (2019)
Background/Aims: Dysregulation of interleukin-6 (IL-6) production in residual renal cells may play a pivotal role in the development of glomerulonephritis (GN). Given that Toll-like receptor 3 (TLR3) signaling has been implicated in the pathogenesis
Externí odkaz:
https://doaj.org/article/f29bddd9c2944d3da8c7f8d6ac7a8812