Zobrazeno 1 - 10
of 39
pro vyhledávání: '"TAC, transverse aortic constriction"'
Autor:
Benjamin Hackl, Eva Zabrodska, Stefanie Gewessler, Elena Lilliu, Eva Maria Putz, Attila Kiss, Bruno Podesser, Hannes Todt, Robin Ristl, Karlheinz Hilber, Xaver Koenig
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionTransverse-aortic constriction (TAC) operation is a widely used animal model to induce hypertrophy and heart failure through left-ventricular pressure overload. In mice, the cardiac response to TAC exhibits considerable variability influe
Externí odkaz:
https://doaj.org/article/544a29aaf92440aca06f75116b01f32f
Autor:
Norbert Frey, Lucie Carrier, Franziska Dierck, Frauke Senger, Gabriele Brunke, Christian Kuhn, Nesrin Schmiedel, Ashraf Yusuf Rangrez, Derk Frank, Susanne Hille, Rainer Will, Samuel Sossalla, Maja Menke, Thomas Eschenhagen, Renate Lüllmann-Rauch, Inga Schmidt, Pia Bünger, Claudia Mack
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • FYCO1, a component of the autophagic machinery, is highly expressed in the heart and a potent inducer of cardiomyocyte autophagy. • Loss of FYCO1 in vivo inhibits adaptation to starvation or biomechanical stress
Highlights • FYCO1, a component of the autophagic machinery, is highly expressed in the heart and a potent inducer of cardiomyocyte autophagy. • Loss of FYCO1 in vivo inhibits adaptation to starvation or biomechanical stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8e5357537596081286716a9a13fac0
http://europepmc.org/articles/PMC8093479
http://europepmc.org/articles/PMC8093479
Akademický článek
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Autor:
Matthias R. Meyer, Matthias Barton
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • The role of ERα non-nuclear signaling in female heart failure was investigated, using a novel mouse line in which ERα non-nuclear signaling was selectively disrupted by inhibiting the interaction between ERα and
Highlights • The role of ERα non-nuclear signaling in female heart failure was investigated, using a novel mouse line in which ERα non-nuclear signaling was selectively disrupted by inhibiting the interaction between ERα and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b353abdb69e8f5cf341a6505d8e5ce74
http://europepmc.org/articles/PMC7091503
http://europepmc.org/articles/PMC7091503
Autor:
Thomas Thum, Sonja Groß
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • After in vitro stimulation or in vivo pressure overload injury, activated cardiac fibroblasts express Ltbp2, Comp, and Cilp. • In ischemic heart disease, LTBP2, COMP, and CILP localize to the fibrotic regions of
Highlights • After in vitro stimulation or in vivo pressure overload injury, activated cardiac fibroblasts express Ltbp2, Comp, and Cilp. • In ischemic heart disease, LTBP2, COMP, and CILP localize to the fibrotic regions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269f954980c6a3f75774662b221dcdaf
https://doi.org/10.1016/j.jacbts.2020.03.013
https://doi.org/10.1016/j.jacbts.2020.03.013
Autor:
Sano, Soichi, Wang, Ying, Yura, Yoshimitsu, Sano, Miho, Oshima, Kosei, Yang, Yue, Katanasaka, Yasufumi, Min, Kyung-Duk, Matsuura, Shinobu, Ravid, Katya, Mohi, Golam, Walsh, Kenneth
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Clonal hematopoiesis can develop from JAK2V617F mutant cells, but mouse models harboring this mutation are confounded by myeloproliferative disease phenotypes. • To establish a model of JAK2V617F clonal hematopoi
Highlights • Clonal hematopoiesis can develop from JAK2V617F mutant cells, but mouse models harboring this mutation are confounded by myeloproliferative disease phenotypes. • To establish a model of JAK2V617F clonal hematopoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::51a7a3a653ac6f636a4d4ca58778a47a
http://europepmc.org/articles/PMC6834960
http://europepmc.org/articles/PMC6834960
Autor:
Jiyuan, Chen, Kaveeta, Kaw, Hailong, Lu, Patricia M, Fagnant, Abhijnan, Chattopadhyay, Xue Yan, Duan, Zhen, Zhou, Shuangtao, Ma, Zhenan, Liu, Jian, Huang, Kristine, Kamm, James T, Stull, Callie S, Kwartler, Kathleen M, Trybus, Dianna M, Milewicz
Publikováno v:
The Journal of Biological Chemistry
Pathogenic variants of the gene for smooth muscle α-actin (ACTA2), which encodes smooth muscle (SM) α-actin, predispose to heritable thoracic aortic disease. The ACTA2 variant p.Arg149Cys (R149C) is the most common alteration; however, only 60% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f72b0fe94460a8619be7f9e99c052b7
https://pubmed.ncbi.nlm.nih.gov/34600884
https://pubmed.ncbi.nlm.nih.gov/34600884
Autor:
Zhen Li, Ya-Xiong Tao, Jianming Kang, Chelsea L. Organ, Ming Xian, Rishi K. Trivedi, David J. Lefer, Jack S. Jenkins, David J. Polhemus, Thomas E. Sharp
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 796-809 (2018)
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 796-809 (2018)
Visual Abstract
Highlights • Pressure overload induced by transverse aortic constriction led to severe heart failure accompanied by renal fibrosis and dysfunction, endothelial dysfunction, and exercise intolerance in mice. • 3-week but not 1
Highlights • Pressure overload induced by transverse aortic constriction led to severe heart failure accompanied by renal fibrosis and dysfunction, endothelial dysfunction, and exercise intolerance in mice. • 3-week but not 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467ef680075b2a1d182bcff8d5d226e3
http://europepmc.org/articles/PMC6315048
http://europepmc.org/articles/PMC6315048
Autor:
Shyam S. Bansal, Bindiya Patel, Sumanth D. Prabhu, Tariq Hamid, Matthias Mack, Gregg Rokosh, Mohamed Ameen Ismahil
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 230-244 (2018)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • Hypothesis: CCR2+ monocyte-derived cardiac macrophages are required for adverse LV remodeling, cardiac T-cell expansion, and the transition to HF following pressure overload. • The imposition of pressure overload
Highlights • Hypothesis: CCR2+ monocyte-derived cardiac macrophages are required for adverse LV remodeling, cardiac T-cell expansion, and the transition to HF following pressure overload. • The imposition of pressure overload
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216a8df09c3fd026815259ef90a80c20
https://doi.org/10.1016/j.jacbts.2017.12.006
https://doi.org/10.1016/j.jacbts.2017.12.006
Publikováno v:
The Journal of Biological Chemistry
Autophagosome–lysosome pathway (ALP) insufficiency has been suggested to play a critical role in the pathogenesis of cardiac hypertrophy. However, the mechanisms underlying ALP insufficiency remain largely unknown, and strategies to specifically ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c5ade638442a6ab31fc6f569d9e71c
https://doi.org/10.1016/j.jbc.2021.101189
https://doi.org/10.1016/j.jbc.2021.101189