Zobrazeno 1 - 10
of 748
pro vyhledávání: '"TAAR1"'
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
For over seven decades, dopamine receptor 2 (D2 receptor) antagonists remained the mainstay treatment for neuropsychiatric disorders. Although it is effective for treating hyperdopaminergic symptoms, it is often ineffective for treating negative and
Externí odkaz:
https://doaj.org/article/48b7396d40bf4f438918c8fc0fa0897f
Akademický článek
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Akademický článek
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Publikováno v:
Клінічна та профілактична медицина, Iss 8, Pp 98-107 (2023)
Introduction. Thyronamines belong to agonists of TAAR1 - trace amine receptors in the brain. The mechanism of activation of the processes of autophagy and neuroplasticity under the action of a synthetic analogue of thyronamines – 4-(4-(2-aminoethox
Externí odkaz:
https://doaj.org/article/9de57ccfcfdf4a7fbe8614d0ee8e2fef
Autor:
Fiona J. Ramage, Spyridon Siafis, Edoardo G. Ostinelli, Virginia Chiocchia, Claire Stansfield, Simonne Wright, Ioannis Mantas, Damian Omari Juma, Grazia Rutigliano, Oliver D. Howes, Francesca Tinsdeall, Lea Milligan, Claire Friedrich, Julian H. Elliott, Carmen Moreno, Ava Homiar, James Thomas, Emily S. Sena, Malcolm R. Macleod, Charlotte Austin, Nobuyuki Nomura, Jaycee Kennett, Soraya Seedat, Luke J. Vano, Andrea Cipriani, Olena Maksym, Jennifer Potts, David Gilbert, Thomy Tonia, Robert A. McCutcheon, Matthias Egger, Stefan Leucht, Toshi A. Furukawa, Hossein Dehdarirad, Janna Hastings, Susan Michie, Georgia Salanti, Olufisayo Elugbadebo, Ouma Simple
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Background Trace amine-associated receptor 1 (TAAR1) agonism shows promise for treating psychosis, prompting us to synthesise data from human and non-human studies. Methods We co-produced a living systematic review of controlled studies examining TAA
Externí odkaz:
https://doaj.org/article/e35d8b7f971f47dfafe6169514abb7b4
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract Ulotaront (SEP‐363856) is a TAAR1 agonist, with 5‐HT1A agonist activity, currently in clinical development for the treatment of schizophrenia. In vitro studies indicate ulotaront is an OCT2‐specific inhibitor with IC50 of 1.27 μM. The
Externí odkaz:
https://doaj.org/article/6ab6e839dc2b4529b1b2f4f221971a6c
Autor:
Anastasia N. Vaganova, Alisa A. Markina, Aleksandr M. Belousov, Karina V. Lenskaia, Raul R. Gainetdinov
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1590 (2024)
Currently, there is a growing amount of evidence for the involvement of dopamine receptors and the functionally related trace amine-associated receptor, TAAR1, in upper intestinal function. In the present study, we analyzed their expression in the du
Externí odkaz:
https://doaj.org/article/cc832b148cfe471bbaa206290f049c4e
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1263 (2024)
Depression is a common mental illness of great concern. Current therapy for depression is only suitable for 80% of patients and is often associated with unwanted side effects. In this regard, the search for and development of new antidepressant agent
Externí odkaz:
https://doaj.org/article/9c9028b1b7fe42a783335cd225777781
Autor:
Nina Dedic, Lien Wang, Eva Hajos-Korcsok, Jacob Hecksher-Sørensen, Urmas Roostalu, Steven P. Vickers, Serena Wu, Christoph Anacker, Colleen Synan, Philip G. Jones, Snezana Milanovic, Seth C. Hopkins, Linda J. Bristow, Kenneth S. Koblan
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101883- (2024)
Objective: Metabolic Syndrome, which can be induced or exacerbated by current antipsychotic drugs (APDs), is highly prevalent in schizophrenia patients. Recent preclinical and clinical evidence suggest that agonists at trace amine-associated receptor
Externí odkaz:
https://doaj.org/article/b7fe5a8971f046fa9b051d0ee080c127
Autor:
Giancarlo Grossi, Naomi Scarano, Francesca Musumeci, Michele Tonelli, Evgeny Kanov, Anna Carbone, Paola Fossa, Raul R. Gainetdinov, Elena Cichero, Silvia Schenone
Publikováno v:
Molecules, Vol 29, Iss 8, p 1739 (2024)
The search for novel effective TAAR1 ligands continues to draw great attention due to the wide range of pharmacological applications related to TAAR1 targeting. Herein, molecular docking studies of known TAAR1 ligands, characterized by an oxazoline c
Externí odkaz:
https://doaj.org/article/c00b5f6dfd8e4b0f9d0943f5ad4f6b79