Výsledky vyhledávání - "T790M mutation"

Akademický článek

Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth

Autor: Rui Zhou, Ziqian Liu, Tongtong Wu, Xianwei Pan, Tongtong Li, Kaiting Miao, Yuru Li, Xiaohui Hu, Haigang Wu, Andrew M. Hemmings, Beier Jiang, Zhenzhen Zhang, Ning Liu

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-25 (2024)

Abstract Background Epidermal growth factor receptor (EGFR) T790M mutation often occurs during long durational erlotinib treatment of non-small cell lung cancer (NSCLC) patients, leading to drug resistance and disease progression. Identification of n

Externí odkaz: https://doaj.org/article/32f0263c738341a7b59930bbe955391a

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Benefits of osimertinib treat a lung adenocarcinoma patient with germline EGFR T790M, somatic EGFR 19-Del, TP53 and PIK3CA mutations

Autor: Yingxue Li, Guangqi Li, Zheng Zheng, Wenjuan Wen, Haihui Zhao, Xia Liu, Jiaping Xie, Lin Han

Publikováno v: Hereditary Cancer in Clinical Practice, Vol 22, Iss 1, Pp 1-7 (2024)

Abstract Background Somatic mutations in the EGFR gene occur in about 50% of non-small cell lung cancers, with the T790M mutation significantly contributing to secondary resistance against EGFR-TKI drugs. However, EGFR T790M germline mutations rarely

Externí odkaz: https://doaj.org/article/801414aafb8f4b39bd0168cfc380ce9a

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Complete response in a lung adenocarcinoma with pleural metastases initially treated with gefitinib and switched to osimertinib after cerebral oligo-progression with unknown T790M mutation: a case report and review of literature

Autor: Mariem Hachlaf, Sihame Lkhoyaali, Wydad Nadir, Hajar Lemsyeh, Brahim El Ghissassi, Hind Mrabti, Saber Boutayeb, Hassan Errihani

Publikováno v: Journal of Medical Case Reports, Vol 18, Iss 1, Pp 1-6 (2024)

Abstract Background First- and second-generation anti-epithelial growth factor receptor tyrosine kinase inhibitors have shown great efficacy in the treatment of advanced adenocarcinoma with epithelial growth factor receptor mutations, but this effica

Externí odkaz: https://doaj.org/article/45e80303c8a348c9ac3efa06ca8337ce

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Clinical pathological characteristics and immune microenvironment significance of EGFR T790M mutation in non-small cell lung cancer patients and its prognostic implications

Autor: LIN Yicong, WANG Yue, XUE Qianqian, ZHENG Qiang, JIN Yan, HUANG Ziling, LI Yuan

Publikováno v: Zhongguo aizheng zazhi, Vol 34, Iss 4, Pp 368-379 (2024)

Background and purpose: Epidermal growth factor receptor exon 20 T790M (EGFR T790M) mutation is one of the acquired resistance mechanisms in non-small cell lung cancer (NSCLC) against first-/second-generation EGFR tyrosine kinase inhibitors (EGFR TKI

Externí odkaz: https://doaj.org/article/3329d381a8a6408caeed833588b68ba7

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Akademický článek

The impact of EGFR T790M mutation status following the development of Osimertinib resistance on the efficacy of Osimertinib in non‐small cell lung cancer: A meta‐analysis

Autor: Liuxian Guo, Guojin Zhou, Min Huang, Kejing Tang, Jing Xu, Jie Chen

Publikováno v: The Clinical Respiratory Journal, Vol 18, Iss 4, Pp n/a-n/a (2024)

Abstract Background Previous studies have suggested that loss of the EGFR T790M gene mutation may contribute to the development of resistance to Osimertinib in non‐small cell lung cancer (NSCLC). Aims This study aims to assess the relationship betw

Externí odkaz: https://doaj.org/article/e624e2337df741148e294f0e3024c734

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Genomic heterogeneity at baseline is associated with T790M resistance mutations in EGFR‐mutated lung cancer treated with the first‐/second‐generation tyrosine kinase inhibitors

Autor: Michael Menzel, Martina Kirchner, Klaus Kluck, Markus Ball, Susanne Beck, Michael Allgäuer, Christin Assmann, Johannes Schnorbach, Anna‐Lena Volckmar, Timothy Kwang Yong Tay, Hannah Goldschmid, Daniel SW Tan, Michael Thomas, Daniel Kazdal, Jan Budczies, Albrecht Stenzinger, Petros Christopoulos

Publikováno v: The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)

Abstract This study analyzed whether extended molecular profiling can predict the development of epidermal growth factor receptor (EGFR) gene T790M mutation, which is the most frequent resistance alteration in non‐small cell lung cancer (NSCLC) aft

Externí odkaz: https://doaj.org/article/592032d0cf624a62bd5f0cb57fe2198c

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Spotlight on Furmonertinib (Alflutinib, AST2818). The Swiss Army Knife (del19, L858R, T790M, Exon 20 Insertions, “uncommon-G719X, S768I, L861Q”) Among the Third-Generation EGFR TKIs?

Autor: Zhang SS, Ou SI

Publikováno v: Lung Cancer: Targets and Therapy, Vol Volume 13, Pp 67-73 (2022)

Shannon S Zhang,1 Sai-hong Ignatius Ou1,2 1University of California Irvine School of Medicine, Department of Medicine, Department of Medicine, Orange, CA, USA; 2Chao Family Comprehensive Cancer Center, Orange, CA, USACorrespondence: Sai-hong Ignatius

Externí odkaz: https://doaj.org/article/c0b4bb84d6304a41a7d91497c12fc669

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Next-generation sequencing-based detection in a breast MMPMN patient with EGFR T790M mutation: a rare case report and literature review

Autor: Huiyun Lv, Aijuan Tian, Shanshan Zhao, Jinbo Zhao, Chen Song

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

Multiple primary malignant neoplasms (MPMNs) are difficult to identify from the metastasis or recurrence of malignant tumors. Additionally, the genetic mutations in each primary tumor vary from each other; therefore, it is critical to explore potenti

Externí odkaz: https://doaj.org/article/c60b37301012401fa2b566c2f742b9d5

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