Identification of pathogenic GCK variants in patients with common type 2 diabetes can lead to discontinuation of pharmacological treatment

Autor: Anne Cathrine Baun Thuesen, Rasmus Tanderup Jensen, Henrik Maagensen, Maja Refshauge Kristiansen, Henrik Toft Sørensen, Allan Vaag, Henning Beck-Nielsen, Oluf B. Pedersen, Niels Grarup, Jens Steen Nielsen, Jørgen Rungby, Anette Prior Gjesing, Heidi Storgaard, Tina Vilsbøll, Torben Hansen

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 35, Iss , Pp 100972- (2023)

Background: Functionally disruptive variants in the glucokinase gene (GCK) cause a form of mild non-progressive hyperglycemia, which does not require pharmacological treatment. A substantial proportion of patients with type 2 diabetes (T2D) carry GCK

Externí odkaz: https://doaj.org/article/1696d215ff0246ea81cfebf50fdc833b

Variation in responses to incretin therapy: Modifiable and non-modifiable factors

Autor: Gregory O. Austin, Alejandra Tomas

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss. Glucagon-like peptide-1 (GLP-1) and glucose-stimulated insulinotro

Externí odkaz: https://doaj.org/article/25fff138d7bd4f0ea275f6014162aa29

Editorial: Beta-Cell Fate: From Gene Circuits to Disease Mechanisms

Autor: Luiza Ghila, Kenichiro Furuyama, Shane T. Grey, Hanne Scholz, Simona Chera

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Externí odkaz: https://doaj.org/article/a95bb2d277024b8081612bbcbbcb458d

Identification of pathogenic GCK variants in patients with common type 2 diabetes can lead to discontinuation of pharmacological treatment

Autor: Thuesen, Anne Cathrine Baun, Jensen, Rasmus Tanderup, Maagensen, Henrik, Kristiansen, Maja Refshauge, Sørensen, Henrik Toft, Vaag, Allan, Beck-Nielsen, Henning, Pedersen, Oluf B., Grarup, Niels, Nielsen, Jens Steen, Rungby, Jørgen, Gjesing, Anette Prior, Storgaard, Heidi, Vilsbøll, Tina, Hansen, Torben

Publikováno v: Thuesen, A C B, Jensen, R T, Maagensen, H, Kristiansen, M R, Sørensen, H T, Vaag, A, Beck-Nielsen, H, Pedersen, O B, Grarup, N, Nielsen, J S, Rungby, J, Gjesing, A P, Storgaard, H, Vilsbøll, T & Hansen, T 2023, ' Identification of pathogenic GCK variants in patients with common type 2 diabetes can lead to discontinuation of pharmacological treatment ', Molecular Genetics and Metabolism Reports, vol. 35, 100972 . https://doi.org/10.1016/j.ymgmr.2023.100972
Mol Genet Metab Rep

Background: Functionally disruptive variants in the glucokinase gene (GCK) cause a form of mild non-progressive hyperglycemia, which does not require pharmacological treatment. A substantial proportion of patients with type 2 diabetes (T2D) carry GCK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a82d8eadf5b37f2de41db6df1c8922
https://pure.au.dk/portal/da/publications/identification-of-pathogenic-gck-variants-in-patients-with-common-type-2-diabetes-can-lead-to-discontinuation-of-pharmacological-treatment(7ba6efbd-a7a6-428b-8011-fd83dc1c6958).html

The Association of Burnout and Vital Exhaustion With Type 2 Diabetes

Autor: Sharon Remmelzwaal, Marije Strikwerda, Miranda T. Schram, Linda J. Schoonmade, Joline W.J. Beulens, Petra J. M. Elders, Annemieke van Straten, Femke Rutters

Publikováno v: Psychosomatic Medicine, 83(9), 1013-1030. Lippincott Williams and Wilkins
Strikwerda, M, Beulens, J W, Remmelzwaal, S, Schoonmade, L J, van Straten, A, Schram, M T, Elders, P J & Rutters, F 2021, ' The Association of Burnout and Vital Exhaustion With Type 2 Diabetes : A Systematic Review and Meta-Analysis ', Psychosomatic Medicine, vol. 83, no. 9, pp. 1013-1030 . https://doi.org/10.1097/PSY.0000000000000995
Strikwerda, M, Beulens, J W, Remmelzwaal, S, Schoonmade, L J, van Straten, A, Schram, M T, Elders, P J & Rutters, F 2021, ' The Association of Burnout and Vital Exhaustion With Type 2 Diabetes : A Systematic Review and Meta-Analysis ', Psychosomatic medicine, vol. 83, no. 9, pp. 1013-1030 . https://doi.org/10.1097/PSY.0000000000000995
Psychosomatic medicine, 83(9), 1013-1030. Lippincott Williams and Wilkins

OBJECTIVE: This study aimed to investigate the association of burnout and vital exhaustion with measures of glycemic control and type 2 diabetes (T2D) in a systematic review and meta-analysis. METHODS: PubMed, Embase, and PsycINFO were searched from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c409e77a82c7a13fb922ea0bc48d1a
https://hdl.handle.net/1871.1/fdd58a87-790a-4a5c-94dd-736e5ff84340